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Abstrak. Atresia esofagus merupakan bentuk kelainan kongenital yang memiliki tingkat mortalitas tinggi berkaitan dengan berbagai komplikasi yang dapat muncul sebelum dan sesudah tindakan operasi definitif. Penelitian ini bertujuan untuk mengetahui faktor – faktor yang mempengaruhi luaran penanganan atresia esofagus. Penelitian ini adalah penelitian analitik retrospektif dari data yang terdapat pada rekam medis pada tahun Januari 2002 hingga Agustus 2009 dari 2 rumah sakit di Bandung, Jawa Barat. Uji Fisher's Exact Probability Test dan Kruskal Walis digunakan untuk menilai luaran masing – masing kelompok. Pada penelitian ini terdapat 26 penderita (13 laki – laki dan 13 perempuan). Rentang usia saat penderita datang ke rumah sakit yaitu 3 ± 1,41 hari. Berat badan lahir rata - rata adalah 2.475 ± 35,35 gram. Pada penelitian ini terdapat hubungan yang signifikan antara keadaan sepsis pra operasi (p= 0.032) dan lama penggunaan ventilator (p= 0.022) dengan luaran penderita atresia esofagus. Sementara tidak terdapat hubungan yang signifikan antara berat badan lahir (p= 0.11), kehadiran pneumonia (p=0.11) , kehadiran kelainan jantung bawaan (p= 0.99) dan jenis ruang rawatan (p= 0.683) terhadap luaran penderita atresia esophagus. (JKS 2017; 2: 72-76)  Kata Kunci: atresia esophagus, faktorresiko, luaran Abstract. Esophageal atresia is a congenital anomaly that have high mortality rate associated with complication appears before and after definitive treatment. Analytic retrospective study to identified risk factors that influence outcome of esophageal atresia. Data were reviewed from medical record of patients with esophageal atresia within January 2002 to August 2009 that hospitalized in 2 hospitals in Bandung, West Java. Fisher's Exact Probability and Kruskal Walis Test were used for the statistical analysis. There are 26 patients (13 boys and 13 girls) with average age when the patients came to hospital is 3 ± 1,41 days old. Mean birth weight among all patients is 2.475 ± 35,35 grams. In this study, sepsis condition before operation and lenght of using ventilator are significant to outcome with (p= 0.032) and (p= 0.022). While birth weight, pneumonia, congenital heart disease, ward during treatment were not significant with (p= 0.11), (p=0.11), (p= 0.99), and (p= 0.683). (JKS 2017; 2: 72-76)  Keywords : esophageal atresia, risk factors, outcome

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Background. Appendicitis is the most common cause of acute abdomen in children. Complicated appendicitis due to perforation associated with high morbidity. Several perioperative conditions fascilitated systemic inflammation and postoperative infectious complication. Synbiotic has a potential effect on reducing inflammatory response which reflected with lower serum c-reactive protein (CRP) level, so that the infectious complication could be avoided. Aim.This study aimed to observe the effect of synbiotic on postoperative serum CRP level reduction in children with complicated appendicitis. Method. A randomized double blind study was done in 26 children with com- plicated appendicitis. The subjects were divided into synbiotic and placebo groups. Synbiotic was given 1 time preoperatively and continued 5 days afer surgery. Serum CRP level were examined preoperatively (CRP 0), postoperative day 1 (CRP 1), and 6 (CRP 6). Statistical analysis was done with Independent-t test (p<0,05 considered significan)t. Result. The mean age of the patients was 9,85 years. The onset of abdominal pain was 3,92 days. The mean reduction of CRP 0 –CRP 6 between synbiotic and placebo group was 65,21% ± 31,37 SD vs 78,29% ± 12,39 SD, p=0,073; and the mean reduction of CRP 1–CRP 6 was 73,54% ± 22,04 vs 74,56% ±17,58, p=0,897. Wound infection was lower in synbiotic group (7,69% vs 38,46%). Conclusion. There was no difference in postoperative serum CRP level reduction between synbiotic therapy and placebo in children with compli- cated appendicitis