PRKCI (protein kinase C, iota)

Justilien, Verline; Fields, AP

doi:10.4267/2042/48364

Cited by 1 publication

(1 citation statement)

References 37 publications

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“…Bodyweights of NA 2 PD‐treated mice remained normal, while the bodyweights of control and DOX groups rapidly decreased by 18 % and 11 %, respectively (Figure 6f, and S30). Besides, we used luciferase‐expressed LLC cells to construct orthotopic NSCLC murine models and monitored the cancer development through bioluminescence [31] . NA 2 PD group mice showed minimal bioluminescent areas and intensities during the treatment (Figure 6g).…”

Section: Resultsmentioning

confidence: 99%

Programmable Assembly of Multivalent DNA‐Protein Superstructures for Tumor Imaging and Targeted Therapy

Shi

et al. 2022

Angewandte Chemie

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Programmable DNA materials hold great potential in biochemical and biomedical researches, yet the complicated synthesis, and the low stability and targeting efficacy in complex biological milieu limit their clinical translations. Here we show a one-pot assembly of DNA-protein superstructures as drug vehicles with specifically high affinity and stability for targeted therapy. This is achieved by biomimetic assembly of programmable polymer DNA wire into densely packed DNA nanosphere with an alkaline protein, protamine. Multivalent DNA nanostructures encoded with different types and densities of aptamers exhibit high affinity to targeted cells through polyvalent interaction. Our results show high cancer cell selectivity, reduced side effect, excellent therapeutic efficacy, and sensitive tumor imaging in both subcutaneous and orthotopic non-small-cell lung cancer murine models. This biomimetic assembly approach provides practical DNA nanomaterials for further clinical trials and may advance oligonucleotide drug delivery.

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Section: Resultsmentioning

confidence: 99%

Programmable Assembly of Multivalent DNA‐Protein Superstructures for Tumor Imaging and Targeted Therapy

Shi

et al. 2022

Angewandte Chemie

View full text Add to dashboard Cite

show abstract

PRKCI (protein kinase C, iota)

Cited by 1 publication

References 37 publications

Programmable Assembly of Multivalent DNA‐Protein Superstructures for Tumor Imaging and Targeted Therapy

Programmable Assembly of Multivalent DNA‐Protein Superstructures for Tumor Imaging and Targeted Therapy

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