The quantum vacuum shows an intensity-dependent nonlinear index of refraction. Consequently, we may consider vacuum as a non-linear medium enabling, at sufficiently high field strengths, a direct interaction of light with light. In this context, we advocate an experiment to measure light-by-light scattering by the means of self-focussing of an x-ray beam in vacuum. Although hard to measure, we argue that for laser beams consisting of highly energetic photons the beams' power distribution carries a distinctive enough signature of self-focussing such that an observation at modern free-electron laser facilities appears possible.Self-focussing also imposes a limit on the most powerful x-ray beams that may propagate in vacuum being on the order of 10 PW for 10 keV x-rays.