Pristane‐induced arthritis. the immunologic and genetic features of an experimental murine model of autoimmune disease

Wooley, Paul H.; Seibold, James R.; Whalen, Janey D.; Chapdelaine, Joan M.

doi:10.1002/anr.1780320812

Cited by 138 publications

(102 citation statements)

References 16 publications

(8 reference statements)

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“…Even though the presence of palisading histiocytes surrounding necrotic nodules could not be ascertained, similar pathology has been reported with pristane-induced arthritis, MRL-lpr͞lpr, and SKG mice but not with CIA in DBA͞1 mice (11,20,21). In contrast to the SKG mice, the D1CC mice had no skin inflammation.…”

Section: Discussionmentioning

confidence: 66%

“…Because the balance between Th1 and Th2 was not significantly different in D1CC mice, aberrant expression of MHC class II together with abnormal selection of T cells such as survival of autoreactive clones will be investigated further. For example, the hCIITA transgene also might influence other types of arthritis in mice and possibly render the arthritis in other animal models, such as SKG mouse, spontaneous (20,32,33). Moreover to create even better and more mouse models of RA, D1CC mice may be backcrossed with the DRB1*0401 or DRB1*0402, and human CD4 double-transgenic mice, which lack I-A␤ Ϫ/Ϫ on the DBA͞1 background (34,35).…”

Section: Discussionmentioning

confidence: 99%

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Aberrant MHC class II expression in mouse joints leads to arthritis with extraarticular manifestations similar to rheumatoid arthritis

Kanazawa¹,

Ota²,

Sekine

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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Genetic susceptibility to rheumatoid arthritis (RA) is associated with certain MHC class II molecules. To clarify the role of these determinants in RA, we generated the D1CC transgenic mouse that expressed genes involved in antigen processing and presentation by the MHC class II pathway in joints. The class II transactivator, which was transcribed from the rat collagen type II promoter and enhancer, directed the expression of these genes. In D1CC mice congenic for the H-2 q (DBA͞1) background, small amounts of bovine collagen type II in adjuvant induced reproducibly an inflammatory arthritis resembling RA. Importantly, these stimuli had no effect in DBA͞1 mice. Eighty-nine percent of D1CC mice developed chronic disease with joint swelling, redness, and heat in association with synovial proliferation as well as pannus formation and mononuclear infiltration of synovial membranes. Granulomatous lesions resembling rheumatoid nodules and interstitial pneumonitis also were observed. As in patients with RA, anticyclic citrullinated peptide antibodies were detected during the inflammatory stage. Finally, joints in D1CC mice displayed juxtaarticular demineralization, severe joint space narrowing, and erosions, which led to ankylosis, but without the appearance of osteophytes. Thus, aberrant expression of MHC class II in joints facilitates the development of severe erosive inflammatory polyarthritis, which is very similar to RA. autoimmunity ͉ class II transactivator ͉ transgenic mouse ͉ nodules ͉ pneumonitis R heumatoid arthritis (RA) is a chronic inflammatory disease with symmetrical inflammatory and erosive polyarthritis of synovial joints and a variety of extraarticular manifestations. Particular MHC class II alleles such as DRB0401, DRB0404, and DQ8 are linked to RA in 30-50% of cases (1-3). To examine possible mechanisms of RA, many models of inflammatory arthritis have been developed in the mouse and rat (4, 5). Among these models, collagen-induced arthritis (CIA) leads to acute inflammation, osteophytosis, and destruction of bone in DBA͞1 and B10.Q (H2 q ) strains of mice (6, 7). In these mice, passively transferred autoantibodies against CII, or the injection of a combination of certain monoclonal anti-CII antibodies, also induce rapid inflammation of joints (8,9). A recently discovered model, the SKG mouse, contains mutations in the chainassociated protein of 70 kDa (ZAP-70) that is involved in the signaling from the T cell antigen receptor (10). In these mice, infection with fungi or immunization with zymosan can induce a chronic inflammatory arthritis (11). In K͞BxN mice, chronic arthritis develops spontaneously because anti-G6PI antibodies accumulate in serum and joints, leading to inflammatory arthritis and bone destruction (12,13). In all these mice and several other models, the onset and progression of inflammatory arthritis have been well characterized and analyzed. However, how faithfully these small animal models resemble RA and what roles MHC class II play in their disease have remained elusive.MHC cla...

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Aberrant MHC class II expression in mouse joints leads to arthritis with extraarticular manifestations similar to rheumatoid arthritis

Kanazawa¹,

Ota²,

Sekine

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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“…For example, it has been shown that the adjuvant composition determines the development of a given antigen-specific autoimmune disease [4] and that injection of adjuvant oil only can induce arthritis In genetically susceptible individuals (rats with RTl'*' [1,5] and mice with H-2q [6]), Sueh studies further indicate that in these situations the adjuvant itself is the critical agent which triggers otherwise well controlled autoreactive cells to become arthritogenic.…”

Section: Discussionmentioning

confidence: 99%

Percutaneous exposure of adjuvant oil causes arthritis in DA rats

Kleinau

Erlandsson²,

Klareskog³

1994

Clinical and Experimental Immunology

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SUMMARYThe arthritogenic properties of adjuvant oil upon percutaneous administration in DA rats was investigated. Groups of rats were administered single or repeated percutaneous applications of Freund's incomplete adjuvant (FI A) or olive oil on shaved skin with or without prior abrasion of the skin. Control rats were shaved and abrased only. A transient arthritis developed in 8/16 animals after repeated applications of FIA on abrased skin. The incidence of arthritis increased to 7/8 animals when FIA was repeatedly administered via filter paper on abrased skin and covered with a bandage. Histological examination of the arthritic joints showed proliferation of the synovial lining layer, infiltration of mononuclear cells and polymorphonuclear cells in the subsynovial tissue. Some bone and cartilage destruction was also seen. Repeated treatment with olive oil on abrased skin induced joint swelling in 3/15 animals, which did not. however, correspond to any microscopically observable signs of inflammation. Also, a single application of FIA on abrased skin or repeated applications of Fi A without abrasion induced arthritis, although with low penetration, whereas control animals had no clinical signs of joint involvement. These findings demonstrate that percutaneous administration of adjuvant oil can cause arthritis in genetically susceptible animals.

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“…The second main reason for our interest in this arthritis in male DBA/l mice is that the males of this strain are particularly susceptible to collagen-induced arthritis (7) as well as pristane-induced arthritis (6). The susceptibility to collagen-induced arthritis and pristane-induced arthritis appears to depend on multiple genes, including MHC class I1 haplotype (6,7) and sex-related genes (8).…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, the DBA/l mouse appears to be particularly susceptible to both collagen-induced arthritis (7) and oil-induced arthritis (6). This susceptibility appears to be dependent on both sex-linked genes (males being more susceptible than females [S]) and non-sex-linked genes (mainly major histocompatibility complex [MHC] class I1 [6,7]), and there are no reports of any generalized immunologic aberration in this mouse strain.…”

mentioning

confidence: 99%

Characterization of a spontaneously occurring arthritis in male DBA/1 mice

Nordling

Karlsson‐Parra

Jansson

et al. 1992

Arthritis & Rheumatism

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Objective. We studied the incidence, severity, histopathologic features, and status of infection in a spontaneous polyarthritis which occurs in male DBAll mice.Methods. Over a 25-week period, the arthritis was evaluated macroscopically in naive mice of different strains. The histopathology was evaluated at different phases of the disease. Virologic and bacterioiogic investigations were performed.Results. The arthritis occurs in -80% of aging male DBM1 mice. The disease is chronic and destructive, and the affected joints are characterized by synovial lining proliferation and infiltration of inflammatory cells, mainly mononuclear. The susceptibility appears to be dependent on both sex-linked and nonsex-linked genes, since female DBM1 mice are not From the

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Pristane‐induced arthritis. the immunologic and genetic features of an experimental murine model of autoimmune disease

Cited by 138 publications

References 16 publications

Aberrant MHC class II expression in mouse joints leads to arthritis with extraarticular manifestations similar to rheumatoid arthritis

Aberrant MHC class II expression in mouse joints leads to arthritis with extraarticular manifestations similar to rheumatoid arthritis

Percutaneous exposure of adjuvant oil causes arthritis in DA rats

Characterization of a spontaneously occurring arthritis in male DBA/1 mice

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