Prise en charge des brûlés graves pendant les 72 premières heures

Gueugniaud, P. Y.

doi:10.1016/s0750-7658(97)81462-1

Cited by 11 publications

(3 citation statements)

References 43 publications

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“…Resuscitation after severe burn, specifically in the first 24 h after injury, is vital for improving the clinical outcomes in patients (20). Our current results confirmed this.…”

Section: Discussionsupporting

confidence: 85%

“…The delayed fluid resuscitation group was set as a positive control. The 6-h delay was chosen as a time division point for delayed fluid resuscitation treatment because fluid loading is one of the key prehospital methods of care to facilitate outcome improvement of severely burned patients over the first 6 h (19,20). Furthermore, severely burned (third-degree) rats would all die after 6 h if no fluid loading was applied, based on our previous study (21).…”

Section: Animals and Treatmentmentioning

confidence: 99%

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The expression profile of aquaporin 1 in rat myocardium after severe burns

Li¹,

Zha²,

Li³

et al. 2015

Turk J Med Sci

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Background/aim: To investigate the myocardial expression profile of aquaporin 1 (AQP1) in rats after severe burns.Materials and methods: Ninety healthy male adult Wistar rats were randomly assigned to the following treatments: sham operation (control group, n = 6), immediate fluid resuscitation treatment post scalding (IF group, n = 42), and delayed fluid resuscitation treatment after scalding (DF group, n = 42). At 3, 6, 12, 24, 48, 72, and 120 h after scalding, myocardial water contents were assayed and AQP1 expressions were detected by real-time polymerase chain reaction and western blot. The AQP levels in the myocardium at 12 h after scalding were assayed by gene microarrays.Results: Scald injuries resulted in significantly synchronized increases in the myocardial water contents and the myocardial mRNA and protein expression of AQP1, with a peak at 12 h after scalding. Rats receiving delayed fluid resuscitation treatment had more severe myocardial edema and significantly higher myocardial AQP1 expressions than the rats receiving immediate fluid resuscitation treatment. The mRNAs of 6 other AQPs (AQP2, 3, 4, 6, 7, and 12b) were found to be changed in the myocardium among rats with different treatments. Conclusion:AQP1 may play a functional role in the development of myocardial edema after scalding. Targeting AQP1 may provide opportunities for therapeutic intervention in myocardial edema following severe burns.

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“…Resuscitation after severe burn, specifically in the first 24 h after injury, is vital for improving the clinical outcomes in patients (20). Our current results confirmed this.…”

Section: Discussionsupporting

confidence: 85%

Section: Animals and Treatmentmentioning

confidence: 99%

The expression profile of aquaporin 1 in rat myocardium after severe burns

Li¹,

Zha²,

Li³

et al. 2015

Turk J Med Sci

View full text Add to dashboard Cite

show abstract

“…This manuscript provides an update on the management of thermal injury affecting adults, concentrating mainly upon the initial resuscitation of the most critically burned patients [10].…”

Section: Introductionmentioning

confidence: 99%