Prise en charge des abcès tubo-ovariens (ATO) et des formes compliquées d’infections génitales hautes. RPC infections génitales hautes CNGOF et SPILF

Graesslin, Olivier; Verdon, Renaud; Raimond, E.; Koskas, Martin; Garbin, O.

doi:10.1016/j.gofs.2019.03.011

Cited by 8 publications

(4 citation statements)

References 43 publications

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“…In more than 75% of patients, antibiotics alone may be sufficient for treating pyosalpinx [ 11 ]. In case of a collection > 3–4 cm, drainage should be performed because the failure rate is higher in the absence of drainage as is the risk of serious complications [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Acute obstructive pyelonephritis due to pyosalpinx: a case report

et al. 2023

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Background A pyosalpinx is the acute inflammation of the fallopian tube, which fills up and swells with pus. It commonly results from inadequate or delayed treatment of pelvic inflammatory disease. Case presentation We report the case of a 54-year-old Africain female patient, who presented with sustained high-grade fever, right flank pain, and severe acute storage low-urinary-tract symptoms. Computed tomography showed signs of acute obstructive pyelonephritis with a right tubular juxtauterine mass with complex internal fluid and thick enhancing walls exerting a mass effect on the right ureter. A drainage of the right excretory cavities by a JJ stent was performed. An ultrasound-guided aspiration of the collection was also performed. Conclusion A pyosalpinx can then exert a mass effect on the excretory cavities, thus causing an acute obstructive pyelonephritis. A double drainage coupled with an effective antibiotic therapy is then necessary.

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Section: Discussionmentioning

confidence: 99%

Acute obstructive pyelonephritis due to pyosalpinx: a case report

et al. 2023

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“…La TDM abdominopelvienne avec injection de produit de contraste peut êtreutile aux diagnostics differentiels d'origine urinaire, digestive ou gynécologique . L'IRM, examen non irradiant, peut êtreréalisée en seconde intention car sa valeur diagnostique et sa spécificité sont meilleures que l'échographie et la TDM abdominopelvienne dans le diagnostic d'ATO [7].…”

Section: Discussion:-unclassified

Aspect Pseudotumoral Dun Abces Tubo-Ovarien

Hilali¹,

Saoud²,

Mamouni³

et al. 2021

IJAR

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Les abces tubo-ovariens sont une complication tardive des infections genitales hautes. Ils regroupent les pyosalpinx, les abces de lovaire, les abces tubo-ovariens proprement dits et les collections abcedees du Douglas dorigine genitale. Leur diagnostic repose sur un trepied clinique, biologique et radiologique. Le traitement associe une antibioterapie parentherale probabiliste avec une ponction drainage de labces echoguidee ou par voie coelioscopique. Le recours Ã la chirurgie est reserve en cas dechec de traitement medical ou en cas de risque vital. Nous rapportons un cas particulier dune patiente Ã¢gee de 28 ans, qui a presente un tableau typique dabces tubo-ovarien mais dont lexploration chirurgicale a mis en evidence une masse annexielle gauche daspect pseudo tumoral suspect avec des adherences au tube digestif, liberees soigneusement, et un epanchement peritoneal de moyenne abondance serohematique, une annexectomie gauche a ete realisee, letude anatomopathologique a conclu au diagnostic dabces tubo-ovarien sans visualisation de lesion tumorale associee.

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“…VWF is an important hemostatic protein and the hydrolyzed production is involved in the adhesion of platelets to the site of vascular injury and the transport of proteins in blood (Braun et al, 2020). Hemostasis is the key in the treatment of pelvic inflammatory disease (Graesslin et al, 2019). Quercetin, one of the most abundant secondary metabolites in PS was confirmed to predominantly improve the platelet function in rats with cholestatic liver injury by up-regulating the expression of VWF, Ca 2+ and ORAI1 (Nassef, 2019).…”

Section: Discussionmentioning

confidence: 99%

A Systematic Study of Mechanism of Sargentodoxa cuneata and Patrinia scabiosifolia Against Pelvic Inflammatory Disease With Dampness-Heat Stasis Syndrome via Network Pharmacology Approach

Chen

et al. 2020

Front. Pharmacol.

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Objective: To investigate the mechanism of Sargentodoxa cuneata (Oliv.) Rehder & E.H.Wilson (SC) and Patrinia scabiosifolia (PS) against Pelvic Inflammatory Disease with Dampness-Heat Stasis Syndrome via network pharmacological approach and experimental validation.Methods: The active compounds with OB ≥ 30% and DL ≥ 0.18 were obtained from TCMSP database and further confirmed by literature research. The targets of the compounds and disease were acquired from multiple databases, such as GeneCards, CTD and TCMSP database. The intersection targets were identified by Venny software. Cytoscape 3.7.0 was employed to construct the protein-protein interaction (PPI) network and compound-target network. Moreover, GO enrichment and KEGG pathway analysis were analyzed by DAVID database. Finally, CCK-8, Griess assay and a cytometric bead array (CBA) immunoassay were used for experimental validation by detecting the influence of the active compounds on proliferation of macrophage, release of NO and TNF-α after LPS treatment.Results: 9 bioactive compounds were identified from SC and PS. Those compounds corresponded to 134 targets of pelvic inflammatory disease with dampness-heat stasis syndrome. The targets include vascular endothelial growth factor A (VEGFA), von willebrand factor (VWF), interleukin 6 (IL6), tumor necrosis factor (TNF) and nuclear transcription factor 1 (NFκB1). They act on the signaling pathways like advanced glycation end products-receptor of advanced glycation end products (AGE-RAGE), focal adhesion (FA), Toll-like receptor (TLR) and nuclear transcription factor κB (NF-κB). In addition, by in vitro validation, the selected active components of SC and PS such as acacetin, kaempferol, linarin, isovitexin, sinoacutine could significantly inhibit the release of NO induced by LPS, respectively. Moreover, different dose of acacetin, kaempferol, isovitexin and sinoacutine significantly inhibits the TNF-α production.Conclusion: This study provides solid evidence for the anti-inflammatory mechanism of SC and PS against pelvic inflammatory disease with dampness-heat stasis syndrome, which will provide a preliminary evidence and novelty ideas for future research on the two herbs.

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Prise en charge des abcès tubo-ovariens (ATO) et des formes compliquées d’infections génitales hautes. RPC infections génitales hautes CNGOF et SPILF

Cited by 8 publications

References 43 publications

Acute obstructive pyelonephritis due to pyosalpinx: a case report

Acute obstructive pyelonephritis due to pyosalpinx: a case report

Aspect Pseudotumoral Dun Abces Tubo-Ovarien

A Systematic Study of Mechanism of Sargentodoxa cuneata and Patrinia scabiosifolia Against Pelvic Inflammatory Disease With Dampness-Heat Stasis Syndrome via Network Pharmacology Approach

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