Printing the Pathway Forward in Bone Metastatic Cancer Research: Applications of 3D Engineered Models and Bioprinted Scaffolds to Recapitulate the Bone–Tumor Niche

Hughes, Anne; Kolb, Alexus D.; Shupp, Alison B.; Shine, Kristy M.; Bussard, Karen M.

doi:10.3390/cancers13030507

Cited by 20 publications

(15 citation statements)

References 224 publications

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“…Finally, validation of novel therapeutic approaches requires testing in pre-clinical models of bone metastasis, which are not yet uniformly available for all bone metastatic cancer entities. While genetically engineered animal models for bone metastatic cancer are scarce, novel patient-derived xenograft models, as well as in vitro organoid and scaffold models recapitulating the bone niche, may be increasingly used to accelerate the development of bone metastasis-targeting compounds [ 259 , 306 , 307 , 308 , 309 , 310 , 311 ]. This most likely requires a joint and multidisciplinary effort between industry and academia to be eventually successful.…”

Section: Discussionmentioning

confidence: 99%

Mechanisms, Diagnosis and Treatment of Bone Metastases

Ban

Fock

Aryee

et al. 2021

Cells

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Bone and bone marrow are among the most frequent metastatic sites of cancer. The occurrence of bone metastasis is frequently associated with a dismal disease outcome. The prevention and therapy of bone metastases is a priority in the treatment of cancer patients. However, current therapeutic options for patients with bone metastatic disease are limited in efficacy and associated with increased morbidity. Therefore, most current therapies are mainly palliative in nature. A better understanding of the underlying molecular pathways of the bone metastatic process is warranted to develop novel, well-tolerated and more successful treatments for a significant improvement of patients’ quality of life and disease outcome. In this review, we provide comparative mechanistic insights into the bone metastatic process of various solid tumors, including pediatric cancers. We also highlight current and innovative approaches to biologically targeted therapy and immunotherapy. In particular, we discuss the role of the bone marrow microenvironment in the attraction, homing, dormancy and outgrowth of metastatic tumor cells and the ensuing therapeutic implications. Multiple signaling pathways have been described to contribute to metastatic spread to the bone of specific cancer entities, with most knowledge derived from the study of breast and prostate cancer. However, it is likely that similar mechanisms are involved in different types of cancer, including multiple myeloma, primary bone sarcomas and neuroblastoma. The metastatic rate-limiting interaction of tumor cells with the various cellular and noncellular components of the bone-marrow niche provides attractive therapeutic targets, which are already partially exploited by novel promising immunotherapies.

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Section: Discussionmentioning

confidence: 99%

Mechanisms, Diagnosis and Treatment of Bone Metastases

Ban

Fock

Aryee

et al. 2021

Cells

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Section: Bioprinting Techniquesmentioning

confidence: 99%

“…There are several 3D bioprinting methods that can be distinguished, e.g., inkjet-based bioprinting, extrusion-based bioprinting, laser-based bioprinting, and stereolithography (Figure 2). Every method has unique advantages and limitations, and it is upon the specific requirements of the tissue being produced that the appropriate printing technique is selected [23,24]. Inkjet-based bioprinting is a technique, which involves jetting the ink through the nozzle of a jetting device in the form of droplets, hence it is also called droplet-based bioprinting.…”

Section: Bioprinting Techniquesmentioning

confidence: 99%

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Perspectives for 3D-Bioprinting in Modeling of Tumor Immune Evasion

Staros

Michalak

Rusinek

et al. 2022

Cancers

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In a living organism, cancer cells function in a specific microenvironment, where they exchange numerous physical and biochemical cues with other cells and the surrounding extracellular matrix (ECM). Immune evasion is a clinically relevant phenomenon, in which cancer cells are able to direct this interchange of signals against the immune effector cells and to generate an immunosuppressive environment favoring their own survival. A proper understanding of this phenomenon is substantial for generating more successful anticancer therapies. However, classical cell culture systems are unable to sufficiently recapture the dynamic nature and complexity of the tumor microenvironment (TME) to be of satisfactory use for comprehensive studies on mechanisms of tumor immune evasion. In turn, 3D-bioprinting is a rapidly evolving manufacture technique, in which it is possible to generate finely detailed structures comprised of multiple cell types and biomaterials serving as ECM-analogues. In this review, we focus on currently used 3D-bioprinting techniques, their applications in the TME research, and potential uses of 3D-bioprinting in modeling of tumor immune evasion and response to immunotherapies.

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“…Moreover, there is no ideal immune-competent mouse model to recapitulate the role of the immune system in disease progression, and the knowledge of understanding the early events of disease progression is poorly understood [216]. Thus, developing Metastasis-on-a-chip together with the immune model system can help to solve the above limitations.…”

Section: Current Challenges and Future Perspectivesmentioning

confidence: 99%

Three-Dimensional (3D) Printing in Cancer Therapy and Diagnostics: Current Status and Future Perspectives

Safhi

2022

Pharmaceuticals

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Three-dimensional (3D) printing is a technique where the products are printed layer-by-layer via a series of cross-sectional slices with the exact deposition of different cell types and biomaterials based on computer-aided design software. Three-dimensional printing can be divided into several approaches, such as extrusion-based printing, laser-induced forward transfer-based printing systems, and so on. Bio-ink is a crucial tool necessary for the fabrication of the 3D construct of living tissue in order to mimic the native tissue/cells using 3D printing technology. The formation of 3D software helps in the development of novel drug delivery systems with drug screening potential, as well as 3D constructs of tumor models. Additionally, several complex structures of inner tissues like stroma and channels of different sizes are printed through 3D printing techniques. Three-dimensional printing technology could also be used to develop therapy training simulators for educational purposes so that learners can practice complex surgical procedures. The fabrication of implantable medical devices using 3D printing technology with less risk of infections is receiving increased attention recently. A Cancer-on-a-chip is a microfluidic device that recreates tumor physiology and allows for a continuous supply of nutrients or therapeutic compounds. In this review, based on the recent literature, we have discussed various printing methods for 3D printing and types of bio-inks, and provided information on how 3D printing plays a crucial role in cancer management.

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Printing the Pathway Forward in Bone Metastatic Cancer Research: Applications of 3D Engineered Models and Bioprinted Scaffolds to Recapitulate the Bone–Tumor Niche

Cited by 20 publications

References 224 publications

Mechanisms, Diagnosis and Treatment of Bone Metastases

Mechanisms, Diagnosis and Treatment of Bone Metastases

Perspectives for 3D-Bioprinting in Modeling of Tumor Immune Evasion

Three-Dimensional (3D) Printing in Cancer Therapy and Diagnostics: Current Status and Future Perspectives

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