Printed Electrochemical Instruments for Biosensors

Beni, Valerio; Nilsson, David; Arvén, Patrik; Norberg, Petronella; Gustafsson, G.; Turner, Anthony

doi:10.1149/2.0011510jss

Cited by 45 publications

(34 citation statements)

References 30 publications

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“…Some have used multiple substrates on which to fabricate various system elements 33 , while others have used prefabricated sub-components such as separate sensor strips and battery components to achieve instrument-free glucose measurement. 33 However, the approach taken here was to demonstrate integration of heterogeneous subsystems on a single substrate, for which all processes must be made fully inter-compatible at the process level. Several integration principles were applied here to achieve integration.…”

Section: Resultsmentioning

confidence: 99%

Biomedical Diagnostics Enabled by Integrated Organic and Printed Electronics

et al. 2017

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Organic and printed electronics integration has the potential to revolutionise many technologies, including biomedical diagnostics. This work demonstrates the successful integration of multiple printed electronic functionalities into a single device capable of the measurement of hydrogen peroxide, and total cholesterol. The single-use device employed printed electrochemical sensors for hydrogen peroxide electroreduction integrated with printed electrochromic display and battery. The system was driven by a conventional electronic circuit designed to illustrate the complete integration of silicon ICs via pick and place, or using organic electronic circuits. The device was capable of measuring 8 µL samples of both hydrogen peroxide (0 to 5 mM, 2.72×10 -6 A.mM -1 ) and total cholesterol in serum from 0 to 9 mM (1.34×10 -8 A.mM -1 , r 2 =0.99, RSD <10%, n=3) which was output on a semi-quantitative linear bar display. The device could operate for 10 minutes via a printed battery and display the result for many hours or days. A mobile phone 'app' was also capable of reading the test result and transmitting this to a remote health care provider. Such a technology could allow improved management of conditions such as hypercholesterolemia.Printed electronics is being hailed as a technological revolution, equal in importance to the emergence of microelectronics over 50 years ago. The combined qualities of print-processable organic, inorganic and hybrid (semi)conductive materials which can be deposited onto flexible polymeric substrates using a range of additive, high throughput printing methodologies offer the prospect of low cost mass production capability and the potential for unprecedented levels of technological integration.

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Section: Resultsmentioning

confidence: 99%

Biomedical Diagnostics Enabled by Integrated Organic and Printed Electronics

et al. 2017

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“…However, there is a small but increasing effort to increase portability through the use of glucometers and smartphones . The introduction of printed electrochemical instruments presents itself as a good perspective for the future.…”

Section: Discussionmentioning

confidence: 99%

Emerging Considerations for the Future Development of Electrochemical Paper‐Based Analytical Devices

et al. 2018

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Meeting the current needs for easier, more precise and faster analyses that also follow the principles of green analytical chemistry requires novel analytical chemistry strategies. Since the appearance in this century of the first device based on a paper platform, many studies have been presented in the literature, providing a wide range of designs and possibilities for the application of paper platforms to electroanalytical systems. This Review gives an overview of the field and can pave the way for the future development of electrochemical paper‐based analytical devices. We also present a critical point of view regarding what has been investigated and developed and what is still missing. This Review discusses the efforts made in the field related to important topics such as the choice of the paper substrate, the device construction process, the characterization of the device, and applications in different areas. In this way, we indicate some steps necessary for optimizing the design of the devices, with a focus on multidisciplinary collaborations that could move entire systems from the bench of the laboratory to the field.

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“…[89] So far, μPED system that is the closest to practical application is demonstrated by Acreo Company (Sweden), who presented an entire glucose detection system equipped with battery, microfluidic sensor and electrochromic display unit on a piece of plastic or paper (Figure 7f). [75,[90][91] However, the printed circuits still base on silicon chip and conventional alkaline battery, which inevitably increases cost and may cause environmental pollution. It is envisioned that in the future μPEDs can be fabricated mainly by paper materials, using paper-based power supplies, the development of which will also be presented later.…”

Section: Medical Diagnosismentioning

confidence: 99%

Section: Environmental Monitoringmentioning

confidence: 99%

Paper‐Based Microfluidics for Electrochemical Applications

2019

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Paper‐based microfluidics is characteristic of fluid transportation through spontaneous capillary action of paper and has exhibited great promise for a variety of applications especially for sensing. Furthermore, paper‐based microfluidics enables the design of miniaturized electrochemical devices to be applied in the energy sector, which is especially attractive for the rapid growing market of small size disposable electronics. This review gives a brief summary on the basics of paper chemistry and capillary‐driven microfluidic behavior, and highlights recent advances of paper‐based microfluidics in developing electrochemical sensing devices and miniaturized energy storage/conversion devices. Their structural features, working principles and exemplary applications are comprehensively elaborated and discussed. Additionally, this review also points out the existing challenges and future opportunities of paper‐based microfluidic electronics.

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Printed Electrochemical Instruments for Biosensors

Cited by 45 publications

References 30 publications

Biomedical Diagnostics Enabled by Integrated Organic and Printed Electronics

Biomedical Diagnostics Enabled by Integrated Organic and Printed Electronics

Emerging Considerations for the Future Development of Electrochemical Paper‐Based Analytical Devices

Paper‐Based Microfluidics for Electrochemical Applications

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