Printed Circuit Board (PCB) Brazing and Ion Source Integration of a High-Field Asymmetric Ion Mobility Spectrometry (FAIMS) Chip

Du, Xin; Mou, Jiahao; Zeng, Hongda; Zeng, Ruosheng; Jiang, Yongrong; Li, Hua

doi:10.1080/00032719.2020.1803347

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…The height of the brazing layer between the upper and lower plates was 0.2 mm. The corresponding surfaces of the upper and lower plates had copper‐coated U‐shaped grooves, 11 and the corresponding surfaces of the upper and lower plates had U‐shaped positioning slots with copper plating, which were enclosed between the two plates using brazing technology to form an enclosed space. The brazing layer, composed of solder paste, had good thermal conductivity.…”

Section: Methodsmentioning

confidence: 99%

“…Based on the structure of the original planar FAIMS, 11 this study combined an additional temperature control function with a UV lamp to test volatile organic compounds (VOC) such as acetone at different temperatures. The experimental results showed that the FAIMS system with temperature control can effectively suppress noise and improve the signal‐to‐noise detection ratio, and the detection signal's repeatability is improved.…”

Section: Introductionmentioning

confidence: 99%

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Design and experiment of high‐field asymmetric waveform ion mobility spectrometry chip based on an integrated temperature control printed circuit board structure

Zeng,

Zhang,

Wang

et al. 2024

Rapid Comm Mass Spectrometry

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RationaleDuring the detection of volatile organic compounds (VOC) using high‐field asymmetric waveform ion mobility spectrometry (FAIMS), the ambient temperature significantly impacts the accuracy of planar FAIMS. To mitigate the influence of ambient temperature on detection accuracy and enhance resolution, a FAIMS system based on the inner impedance characteristics of a printed circuit board (PCB) was designed for temperature control.MethodsThis study, conducted under standard atmospheric pressure, aimed to assess the signal stability of a planar FAIMS instrument with and without temperature control, and the effect of temperature change on the detection ability of acetone, ethanol, and their mixture was studied using PCB self‐heating.ResultsExperimental results demonstrated that the base noise in FAIMS with temperature control was 0.2 pA, whereas that in FAIMS without temperature control was 1.8 pA. Notably, with increasing temperature, the detection ability of FAIMS changes accordingly. The optimal relative detection ability of acetone was observed when the electrode plate was heated to 45°C under an electric field of 15 kV/cm.ConclusionsThis study provides a novel approach to improve the resolving power of FAIMS systems and their signal‐to‐noise ratio. The utilization of a PCB‐based temperature control proved effective in stabilizing FAIMS signal characteristics and optimizing detection capabilities, particularly for VOCs such as acetone. These findings have significant implications for improving the accuracy and resolving power of FAIMS systems in VOC detection applications.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design and experiment of high‐field asymmetric waveform ion mobility spectrometry chip based on an integrated temperature control printed circuit board structure

Zeng,

Zhang,

Wang

et al. 2024

Rapid Comm Mass Spectrometry

Self Cite

View full text Add to dashboard Cite

show abstract

“…At the same time, it has the characteristics of high speed and high precision. The PCB brazing FAIMS chip has been clearly described in our previous research 17 . The chip is based on a PCB brazing process FAIMS system board with a helium ventilation device added.…”

Section: Methodsmentioning

confidence: 99%

Simultaneously improving the resolving power and sensitivity for planar high‐field asymmetric waveform ion mobility spectrometry using a mixed gas inlet mode at two ends

Zeng

et al. 2021

Rapid Comm Mass Spectrometry

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Rationale Resolution and sensitivity are two key parameters for describing the performance of high‐field asymmetric waveform ion mobility spectrometry (FAIMS). An increase in the resolving power of FAIMS has been realized by adding helium to nitrogen in planar FAIMS, but it comes at the expense of sensitivity. Methods Here, a new hollow needle‐to‐ring discharge device integrated on a PCB substrate is used as the ion source for FAIMS. Helium flows from the hollow part of the hollow needle to improve the ionization effect. Nitrogen carries the sample into the ionization chamber and is mixed with helium as the carrier gas. Results Under a nitrogen flow rate of 1 L min−1, 1.5 L min−1, 2 L min−1, and 2.5 L min−1, adding helium at different flow rates (0.2 L min−1, 0.3 L min−1, 0.5 L min−1, and 1 L min−1) can simultaneously improve the separation ability and sensitivity. Helium and nitrogen with flow rates of 0.2, 0.3, 0.5, and 1 L min−1 were added to nitrogen (2 L min−1). The separation ability and sensitivity of the mixed gases doped with helium are better than those of nitrogen. The larger the RF voltage amplitude is, the more obvious the improvement in the separation ability when helium is added. However, helium doping has the opposite effect on the sensitivity. Conclusions This study provides a new idea and technical means for the application of helium and nitrogen gas mixtures in planar FAIMS. This method can greatly improve the performance of FAIMS.

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Identification of soy sauce using high-field asymmetric waveform ion mobility spectrometry combined with machine learning

Jin

Liu

et al. 2022

Sensors and Actuators B: Chemical

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Printed Circuit Board (PCB) Brazing and Ion Source Integration of a High-Field Asymmetric Ion Mobility Spectrometry (FAIMS) Chip

Cited by 6 publications

References 16 publications

Design and experiment of high‐field asymmetric waveform ion mobility spectrometry chip based on an integrated temperature control printed circuit board structure

Design and experiment of high‐field asymmetric waveform ion mobility spectrometry chip based on an integrated temperature control printed circuit board structure

Simultaneously improving the resolving power and sensitivity for planar high‐field asymmetric waveform ion mobility spectrometry using a mixed gas inlet mode at two ends

Identification of soy sauce using high-field asymmetric waveform ion mobility spectrometry combined with machine learning

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