Principles of premetastatic niche formation

Korneva, Yu. S.; Сергеевна, Корнева Юлия; Украинец, Р. В.; Вадимович, Украинец Роман

doi:10.26442/18151434.2019.4.190715

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…Even before DTC spreading, factors determined by the primary tumor recruit immune cells to the sites where they change the conditions to produce a premetastatic niche (PMN) prepared for being colonized by DTCs [ 128 , 129 ]. Namely, an immunosuppressive microenvironment is prepared.…”

Section: Premetastatic Nichesmentioning

confidence: 99%

Dormancy: There and Back Again

Pshennikova

Voronina

2022

Mol Biol

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Many cells are capable of maintaining viability in a non-dividing state with minimal metabolism under unfavorable conditions. These are germ cells, adult stem cells, and microorganisms. Unfortunately, a resting state, or dormancy, is possible for tuberculosis bacilli in a latent form of the disease and cancer cells, which may later form secondary tumors (metastases) in different parts of the body. These cells are resistant to therapy that can destroy intensely dividing cells and to the host immune system. A cascade of reactions that allows cells to enter and exit dormancy is triggered by regulatory factors from the microenvironment in niches that harbor the cells. A ratio of forbidding and permitting signals dictates whether the cells become dormant or start proliferation. The only difference between the cell dormancy regulation in normal and pathological conditions is that pathogens, mycobacteria, and cancer cells can influence their own fate by changing their microenvironment. Certain mechanisms of these processes are considered in the review.

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Section: Premetastatic Nichesmentioning

confidence: 99%

Dormancy: There and Back Again

Pshennikova

Voronina

2022

Mol Biol

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MRI Semiotics Features and Difficulties of Differential Diagnosis of Hepatic Metastases from Neuroendocrine Tumours

Лаптева¹,

Sergeeva²,

Перегудов³

et al. 2023

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Relevance: Isolated bilobar multifocal hepatic lesion is consider to be the most common metastatic neuroendocrine tumor(NET) growth pattern. Underestimation of the metastatic burden in the NET patients at the initial diagnosis frequently occurs, thus leading to a high postoperative recurrence rate (more than 60 % of cases within 5 years).Purpose: To identify the MRI-hallmarks of liver metastatic NETs and to present the most difficult diagnostic cases.Material and methods: 103 patients with histology confirmed liver metastatic NET were enrolled in the study. All patients underwent abdominal contrast-enhanced (CE) MRI. A total of 241 lesions were assessed. Quantitative indicators of signal intensity (SI) on native and post-contrast T1-weighted images (WI) were measured in metastases. Additionally, the shape, contours, surface of metastases, SI on native images, characteristics of CE, the presence of hemoglobin degradation products and the boundary levels in the structure of metastases were qualitatively assessed.Results: Metastatic liver disease in NET is mostly multifocal: 78 (75.7 %) patients had 5 or more lesions. Metastases were round in 53.5 % of cases, oval in 17.5 % of cases, irregular in 29 % of cases. In 61 % of cases, the contours of the lesions were clear, in 39 % — indistinct. Smooth and bumpy surface of metastases was determined in 31.5 % and 68.5 % of cases, respectively. The presence of hemoglobin degradation products in the structure of metastases was determined in 26.2 % of patients, the formation of the boundary levels — in 8.1 % of patients. Most of the lesions had a hyperintense signal on T2-WI with and without FS and a hypointense signal on native T1-WI. The proportions of actively, moderately and poorly MR contrast agent (MRCA) enhanced lesions were 30.8, 32.6 and 36.6 %, in the arterial phase and 16.3, 55.4 and 28.3 % in the venous phase, respectively. The apparent diffusion coefficient (ADC) values varied significantly. In some cases, small metastatic NET were visualized only in the arterial phase of CE and were not detected on other MRI sequences, thus requiring differentiation from other hepatic hypervascular lesions.Conclusion. The MRI semiotics features of hepatic metastases from NETs is described. Small flesions of active accumulation of MRCA in the arterial phase in the presence of primary NET must be differentiated from metastatic lesions.

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Principles of premetastatic niche formation

Cited by 2 publications

References 48 publications

Dormancy: There and Back Again

Dormancy: There and Back Again

MRI Semiotics Features and Difficulties of Differential Diagnosis of Hepatic Metastases from Neuroendocrine Tumours

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