Principles of Nuclear Cardiology Imaging

Garcia, Ernest; Galt, James R.; Faber, Tracy L.; Chen, Ji

doi:10.1007/978-1-4614-5551-6_1

Cited by 10 publications

(14 citation statements)

References 27 publications

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“…However research reports with this product are lacking at present. The positron range of 13 N ammonia is 2.53 mm (5) resulting in an intermediate-high image resolution as compared to other PET MPI tracers (Figure 1). The myocardial extraction fraction of 13 N ammonia is is approximately 80% (Table 1).…”

Section: Current Myocardial Perfusion Pet Tracersmentioning

confidence: 97%

“…In other words, the higher the energy of the emitted positron, the longer the positron range and the lower the image resolution (Figure 1). 15 O has a 4.14 mm positron range (5) resulting in an intermediate image resolution (Figure 1). …”

Section: Current Myocardial Perfusion Pet Tracersmentioning

confidence: 99%

“…The physical half-life of 13 N ammonia is 9.96 minutes (5). As such, its production has required an on-site cyclotron (Table 1).…”

Section: Current Myocardial Perfusion Pet Tracersmentioning

confidence: 99%

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Cardiac PET Perfusion Tracers: Current Status and Future Directions

Maddahi

Packard

2014

Seminars in Nuclear Medicine

125

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Positron emission tomography (PET) myocardial perfusion imaging (MPI) is increasingly used for non-invasive detection and evaluation of coronary artery disease (CAD). However, the widespread use of PET MPI has been limited by shortcomings of the current PET perfusion tracers. Availability of these tracers is limited by need for an on-site (15O water and 13N ammonia) or nearby (13N ammonia) cyclotron or commitment to costly generators (82Rb). Due to short half-lives ranging from 76sec for 82Rb, to 2.1min for 15O water and 10min for 13N ammonia, their use in conjunction with treadmill exercise stress testing is either not possible (82Rb and 15O water) or is not practical (13N ammonia). Furthermore, the long positron range of 82Rb makes image resolution suboptimal and its low extraction limits its defect resolution. In recent years, development of an 18F labeled PET perfusion tracer has gathered considerable interest. The longer half-life of 18F (108 minutes) would make the tracer available as a unit dose from regional cyclotrons and allow use in conjunction with treadmill exercise testing. Furthermore, the short positron range of 18F would result in better image resolution. 18F flurpiridaz is by far the most thoroughly studied in animal models, and is the only F18-based PET MPI radiotracer currently undergoing clinical evaluation. Pre-clinical and clinical experience with 18F flurpiridaz demonstrated a high myocardial extraction fraction, high image and defect resolution, high myocardial uptake, slow myocardial clearance, and high myocardial-to-background contrast which was stable over time – important properties of an ideal PET MPI radiotracer. Pre-clinical data from other 18F labeled myocardial perfusion tracers are encouraging.

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Section: Current Myocardial Perfusion Pet Tracersmentioning

confidence: 97%

Section: Current Myocardial Perfusion Pet Tracersmentioning

confidence: 99%

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Cardiac PET Perfusion Tracers: Current Status and Future Directions

Maddahi

Packard

2014

Seminars in Nuclear Medicine

125

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“…2 There is a misconception that MRI, echo and CT are superior to nuclear cardiology imaging because of their superior spatial resolution. Yet, in detecting perfusion defects, what is really necessary is contrast resolution, and it is this superior contrast resolution that allows one to differentiate between normal and hypoperfused myocardium, facilitating the visual and quantitative analysis of nuclear cardiology perfusion images.…”

Section: Inherent Advantages Of Nuclear Cardiologymentioning

confidence: 99%

Advances in Software for Faster Procedure and Lower Radiotracer Dose Myocardial Perfusion Imaging

Piccinelli

Garcia

2015

Progress in Cardiovascular Diseases

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“…9,10 For instance, less shielding may be required for the use of 82 Rb than for 18 F-labeled radiotracers because of the difference in their halflives. 11 Administration of an 18 F-labeled radiopharmaceutical during exercise-induced stress may require a shielded exercise room. A room with two exterior walls requires less shielding than an interior space adjacent to waiting rooms.…”

Section: Facility and Space Considerationsmentioning

confidence: 99%

Practical issues regarding the incorporation of PET into a busy SPECT practice

Heller

2012

Journal of Nuclear Cardiology

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Incorporating positron emission tomography (PET) imaging or PET/computed tomographic (PET/CT) imaging into a clinical cardiology practice provides opportunities to better assess patients as well as to expand the services offered by the practice. Clinical evidence continues to accrue, demonstrating the superior quality, the breadth of assessments possible, the diagnostic certainty and accuracy, and the lower patient radiation exposure of PET versus single-photon emission computerized tomography (SPECT) myocardial perfusion imaging (MPI). PET imaging is more accessible to non-hospital imaging centers than ever before because of the availability of radiopharmaceuticals that can be generated on-site or delivered in unit doses from regional cyclotrons, and camera systems of lower cost than previously available. In this manuscript, we offer guidance on the many factors a practice must address before replacing an aging SPECT camera or adding new PET or PET/CT imaging capabilities. Key among these are defining the PET and CT procedures the practice members wish to perform, learning the equipment and radiotracers required to perform those procedures, determining whether their facility has sufficient physical space and shielding to accommodate the dedicated PET or PET/CT instrumentation, and addressing issues related to the practice's referral base, competition, cost-of-entry, reimbursement, and return on investment.

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Principles of Nuclear Cardiology Imaging

Cited by 10 publications

References 27 publications

Cardiac PET Perfusion Tracers: Current Status and Future Directions

Cardiac PET Perfusion Tracers: Current Status and Future Directions

Advances in Software for Faster Procedure and Lower Radiotracer Dose Myocardial Perfusion Imaging

Practical issues regarding the incorporation of PET into a busy SPECT practice

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