Principles of nanosized drug delivery systems

Peltonen, Leena; Singhal, Mayank; Hirvonen, Jouni

doi:10.1016/b978-0-08-102985-5.00001-2

Cited by 15 publications

(12 citation statements)

References 93 publications

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“…PLL, a biocompatible and biodegradable polymer of the amino acid L-lysine exerts these effects, and apart from the provision of functional amino groups for the easy conjugation of other components, its net electropositive charge promotes an electrostatic interaction with the electronegative cellular membrane, aiding NP uptake [ 23 , 24 ]. The pegylation of NPs, among other things, confers stealth properties and correlates with increased residence time in vivo [ 22 , 25 ]. Therefore, we assessed the impact of surface design on NP efficiency, comparing the activities of PEG-coated nanocomplexes to the PLL-g-PEG-coated variant.…”

Section: Introductionmentioning

confidence: 99%

Modified Gold Nanoparticles for Efficient Delivery of Betulinic Acid to Cancer Cell Mitochondria

Oladimeji

Akinyelu

Daniels

et al. 2021

IJMS

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Advances in nanomedicine have seen the adaptation of nanoparticles (NPs) for subcellular delivery for enhanced therapeutic impact and reduced side effects. The pivotal role of the mitochondria in apoptosis and their potential as a target in cancers enables selective induction of cancer cell death. In this study, we examined the mitochondrial targeted delivery of betulinic acid (BA) by the mitochondriotropic TPP+-functionalized epigallocatechin gallate (EGCG)-capped gold NPs (AuNPs), comparing the impact of polyethylene glycol (PEG) and poly-L-lysine-graft-polyethylene glycol (PLL-g-PEG) copolymer on delivery efficacy. This included the assessment of their cellular uptake, mitochondrial localization and efficacy as therapeutic delivery platforms for BA in the human Caco-2, HeLa and MCF-7 cancer cell lines. These mitochondrial-targeted nanocomplexes demonstrated significant inhibition of cancer cell growth, with targeted nanocomplexes recording IC50 values in the range of 3.12–13.2 µM compared to that of the free BA (9.74–36.31 µM) in vitro, demonstrating the merit of mitochondrial targeting. Their mechanisms of action implicated high amplitude mitochondrial depolarization, caspases 3/7 activation, with an associated arrest at the G0/G1 phase of the cell cycle. This nano-delivery system is a potentially viable platform for mitochondrial-targeted delivery of BA and highlights mitochondrial targeting as an option in cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Modified Gold Nanoparticles for Efficient Delivery of Betulinic Acid to Cancer Cell Mitochondria

Oladimeji

Akinyelu

Daniels

et al. 2021

IJMS

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“…Generally, polymeric nanoparticles are composed of natural polymers (chitosan and alginate) and synthetic polymers (PLGA and cyclodextrins) [104]. There are many advantages to using polymeric nanoparticles for the delivery of anticancer drugs in cancer treatment, among others, they can be used to deliver various types of drugs such as hydrophilic and hydrophobic drugs, peptides, and biological macromolecules via several routes of administration [105], improve the drug solubility [106], provide controlled release, increase bioavailability, therapeutic index, can transport active ingredients to targeted tissues or organs at a specified concentration [102,107], surface modification with ligand linking for stealth and targeted drug delivery, biocompatibility, biodegradability, and low toxicity [108].…”

Section: Polymeric Nanoparticlementioning

confidence: 99%

Nanoformulations of α-Mangostin for Cancer Drug Delivery System

et al. 2021

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Natural compounds are emerging as effective agents for the treatment of malignant diseases. The active constituent of α-mangostin from the pericarp of Garcinia mangostana L. has earned significant interest as a plant base compound with anticancer properties. Despite α-mangostin’s superior properties as an anticancer agent, its applications are limited due to its poor solubility and physicochemical stability, rapid systemic clearance, and low cellular uptake. Our review aimed to summarize and discuss the nanoparticle formulations of α-mangostin for cancer drug delivery systems from published papers recorded in Scopus, PubMed, and Google Scholar. We investigated various types of α-mangostin nanoformulations to improve its anticancer efficacy by improving bioavailability, cellular uptake, and localization to specific areas These nanoformulations include nanofibers, lipid carrier nanostructures, solid lipid nanoparticles, polymeric nanoparticles, nanomicelles, liposomes, and gold nanoparticles. Notably, polymeric nanoparticles and nanomicelles can increase the accumulation of α-mangostin into tumors and inhibit tumor growth in vivo. In addition, polymeric nanoparticles with the addition of target ligands can increase the cellular uptake of α-mangostin. In conclusion, nanoformulations of α-mangostin are a promising tool to enhance the cellular uptake, accumulation in cancer cells, and the efficacy of α-mangostin as a candidate for anticancer drugs.

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“…Passive targeting can enhance the penetration of nanoparticles to the tumor tissue site through an enhanced permeability and retention (EPR) effect [ 31 , 32 , 33 , 34 , 35 ]. Meanwhile, active targeting contains structural modifications and surface functionalization of nanoparticles that lead to more specific targeting capabilities [ 36 , 37 ]. The limited selectivity of nanoparticles against cancer excludes the benefits of nanoparticle drug delivery for effective chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid-Coated Chitosan Nanoparticles as an Active Targeted Carrier of Alpha Mangostin for Breast Cancer Cells

et al. 2023

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Alpha mangostin (AM) has potential anticancer properties for breast cancer. This study aims to assess the potential of chitosan nanoparticles coated with hyaluronic acid for the targeted delivery of AM (AM-CS/HA) against MCF-7 breast cancer cells. AM-CS/HA showed a spherical shape with an average diameter of 304 nm, a polydispersity index of 0.3, and a negative charge of 24.43 mV. High encapsulation efficiency (90%) and drug loading (8.5%) were achieved. AM released from AM-CS/HA at an acidic pH of 5.5 was higher than the physiological pH of 7.4 and showed sustained release. The cytotoxic effect of AM-CS/HA (IC50 4.37 µg/mL) on MCF-7 was significantly higher than AM nanoparticles without HA coating (AM-CS) (IC50 4.48 µg/mL) and AM (IC50 5.27 µg/mL). These findings suggest that AM-CS/HA enhances AM cytotoxicity and has potential applications for breast cancer therapy.

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Principles of nanosized drug delivery systems

Cited by 15 publications

References 93 publications

Modified Gold Nanoparticles for Efficient Delivery of Betulinic Acid to Cancer Cell Mitochondria

Modified Gold Nanoparticles for Efficient Delivery of Betulinic Acid to Cancer Cell Mitochondria

Nanoformulations of α-Mangostin for Cancer Drug Delivery System

Hyaluronic Acid-Coated Chitosan Nanoparticles as an Active Targeted Carrier of Alpha Mangostin for Breast Cancer Cells

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