Nanoformulations of α-Mangostin for Cancer Drug Delivery System

Abstract

Natural compounds are emerging as effective agents for the treatment of malignant diseases. The active constituent of α-mangostin from the pericarp of Garcinia mangostana L. has earned significant interest as a plant base compound with anticancer properties. Despite α-mangostin’s superior properties as an anticancer agent, its applications are limited due to its poor solubility and physicochemical stability, rapid systemic clearance, and low cellular uptake. Our review aimed to summarize and discuss the nanoparticle formulations of α-mangostin for cancer drug delivery systems from published papers recorded in Scopus, PubMed, and Google Scholar. We investigated various types of α-mangostin nanoformulations to improve its anticancer efficacy by improving bioavailability, cellular uptake, and localization to specific areas These nanoformulations include nanofibers, lipid carrier nanostructures, solid lipid nanoparticles, polymeric nanoparticles, nanomicelles, liposomes, and gold nanoparticles. Notably, polymeric nanoparticles and nanomicelles can increase the accumulation of α-mangostin into tumors and inhibit tumor growth in vivo. In addition, polymeric nanoparticles with the addition of target ligands can increase the cellular uptake of α-mangostin. In conclusion, nanoformulations of α-mangostin are a promising tool to enhance the cellular uptake, accumulation in cancer cells, and the efficacy of α-mangostin as a candidate for anticancer drugs.

Investigation and optimization of naringin-loaded in MOF-5 encapsulated by liponiosomes as smart drug delivery, cytotoxicity, and apoptotic on breast cancer cells

“…This combination exhibits interesting synergistic antiproliferative effects compared to either compound alone [12]. Nanoformulations are commonly utilized to enhance the solubility, bioavailability, and e cacy of insoluble drugs [13]. These formulations include polymeric NPs [14], solid lipid NPs [15], nanostructured lipid carriers, niosomes (Nio) [16], and liposomes (LPs) [17].…”

Hyaluronic Acid-Coated Chitosan Nanoparticles as an Active Targeted Carrier of Alpha Mangostin for Breast Cancer Cells

“…AM has antiproliferative activity and apoptotic effects on different types of cancer, one of which is breast cancer, among the mechanisms of inducing apoptosis in breast cancer cells through the downregulation of B-cell lymphoma 2 (Bcl2) and the upregulation of Bcl-2-associated X protein (Bax) against breast cancer cells [ 6 , 7 , 8 , 9 , 10 ]. In addition to its anticancer activity, AM has limitations due to its poor solubility [ 11 ], the first fast metabolism reaction, efflux reactions caused by intercellular transporters, rapid drug release, and low selectivity for cancer cells [ 6 , 12 , 13 , 14 ].…”

Phytochemical and Pharmacological Values of Two Major Constituents of Asparagus Species and their Nano formulations: A Review

“…This made nanomedicines to be able to overcome the limitations of conventional therapy 24 such as high frequency of drug administration 20 improve the delivery of a hydrophilic drug into cells 25 improve the bioavailability of poorly soluble drugs, control/sustain drug release 26,27 and aid crossing the blood-brain barrier 28,29 . Nanoparticles (NPs) have been applied previously for diagnosis, prevention, and treatment of several diseases such as viral infections with promising results 27,[30][31][32][33] , and and also, they demonstrated a good antibacterial activity against multidrug resistant bacteria, 17,[34][35][36][37][38][39] and for treatment of cancer, Alzheimer's, tuberculosis, wound healing repairing damaged tissue [40][41][42] , and inflammation 43 .…”