Principles of Cancer Chemotherapy

Ewesuedo, Reginald; Ratain, Mark J.

doi:10.1007/978-3-642-55780-4_3

Cited by 21 publications

(14 citation statements)

References 225 publications

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“…Regardless of the advancement in therapeutic cocktails, the conclusion of chemotherapy remains unsatisfactory. For demonstration, the response rate of pancreatic cancerous disease, oesophageal cancerous disease and ovarian cancerous disease to chemotherapy are well underneath 20% [26]. Even in patients with malignancies that are more perceptive to chemotherapeutic agencies, e.g.…”

Section: Introductionmentioning

confidence: 99%

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Nanostructured Lipid Carriers: A potential drug carrier for cancer chemotherapy

2012

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Nanotechnology having developed exponentially, the aim has been on therapeutic undertaking, particularly for cancerous disease chemotherapy. Nanostructured lipid carriers have attracted expanding scientific and commercial vigilance in the last couple of years as alternate carriers for the pharmaceutical consignment, particularly anticancer pharmaceuticals. Shortcomings often came across with anticancer mixtures, such as poor solubility, normal tissue toxicity, poor specificity and steadiness, as well as the high incidence rate of pharmaceutical resistance and the rapid degradation, need of large-scale output procedures, a fast release of the pharmaceutical from its carrier scheme, steadiness troubles, the residues of the organic solvents utilized in the output method and the toxicity from the polymer with esteem to the carrier scheme are anticipated to be overcome through use of the Nanostructured Lipid Carrier. In this review the benefits, types, drug release modulations, steadiness and output techniques of NLCs are discussed. In supplement, the function of NLC in cancer chemotherapy is presented and hotspots in research are emphasized. It is foreseen that, in the beside future, nanostructured lipid carriers will be further advanced to consign cytotoxic anticancer compounds in a more efficient, exact and protected manner.

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Section: Introductionmentioning

confidence: 99%

“…Cytotoxic anticancer pharmaceuticals are known for their heterogeneity. They constitute a class of compounds with highly varied molecular structure and physicochemical properties [26]. A carrier material, such as polymers, that can join one cytotoxic drug may not be compatible with another one.…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Lipid Carriers: A potential drug carrier for cancer chemotherapy

2012

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“…For demonstration, the response rate of pancreatic cancerous ailment, esophageal cancerous disease and gonad cancerous disease to therapy are well beneath 2%. [105] Even in patients with malignancies that are a lot of perceptive to chemotherapeutical agencies, e.g. For breast cancers, the clinical conclusions are usually below expectation.…”

Section: Drawbacks Encountered During Cancer Therapy and How Nlc Overmentioning

confidence: 99%

Comprehensive Interpretation of Nanostructured Lipid Carriers (Nlc): A Promising New Generation Lipid Carrier for the Delivery of Cancer Chemotherapeutics

Wang¹

2017

WJPR

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In the last couple of years, Nano-carries have attracted large amount of consideration in drug delivery specifically for cancer chemotherapy.There are shortcomings which greatly hindered anti-cancer drug delivery such as poor-aqueous solubility, toxicity towards normal tissues, limited targeting ability, inefficient large-scale production output, rapid degradation and quick release from the formulations. The amount of studies analyzing formulations based on nanostructured lipid carriers (NLCs) has been significantly increased. This increase in NLC investigation is possibly due to its ability to overcome the physiological obstacles and enhanced understanding of mechanism of action NLCs in vitro and in vivo via different route of administration in recent years. Toxicity related concerns like-presence of organic residues and polymers are tactically bypassed by using nanostructured lipid carriers. In this review we have discussed the types, preparation procedure and physicochemical characterization technique of NLCs. In addition, the roles NLCs can play in cancer

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“…Surgical procedures usually lead to significant morbidity such as lymph edema, muscle wasting, neuropathy and chronic pain (Paci et al, 1996). Radiation therapy is useful for cancer which is more localized, but it also carry a number of acute and chronic side-effects such as nausea, diarrhea, pain and fatigue (Ewesuedo & Ratain, 2003). Endocrine therapy may be used as a supplementary treatment.…”

Section: Introductionmentioning

confidence: 99%

“…The cytotoxic drugs treat cancers by causing cell death or growth arrest. Effective cancer chemotherapy is able either to shrink a tumor or to help destroy cancer cells (Ewesuedo & Ratain, 2003). A number of obstacles such as drug toxicity, possible undesirable drug interactions and various forms of drug resistance have to be overcome to achieve effective chemotherapy (Cardosa et al, 2009).…”

Section: Introductionmentioning

confidence: 99%