Principles of breeding; a treatise on thremmatology or the principles and practices involved in the economic improvement of domesticated animals and plants, by E. Davenport ... with appendix by H. L. Rietz.

Davenport, E.; Rietz, H. L.

doi:10.5962/bhl.title.27742

Cited by 3 publications

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“…We found that the skin is indeed highly susceptible to PI and that genes contributing to barrier function are selectively downregulated. Concentrations well below the peak plasma concentration in therapeutic settings were effective (7), and susceptibility of the skin was furthermore illustrated by the similar concentration range typically employed for in vitro studies of multiple myeloma cells (27,28). The downregulated genes, as identified here, are implicated in the establishment of the cornified envelope (39), while other genes highly expressed by KCs remained either unchanged (krt14) or experienced regulation to the opposite [like jagged-2 (47)], further underlining the susceptibility of the skin to PI.…”

Section: Discussionmentioning

confidence: 92%

“…Normal and malignant plasma cells are critically dependent on unperturbed proteasome function (10,(27)(28)(29), but studies investigating the consequences of PI on the allergic immune response are limited. In fact, one recent report failed to detect changes in the plasma cell compartment and achieved IgE suppression only upon prolonged treatment with Bz in a model of OVA-driven chronic asthma (14).…”

Section: Discussionmentioning

confidence: 99%

“…Other genes highly expressed in the skin showed either no effect (keratin 14) or were even upregulated (jagged-2), implying particular susceptibility of genes involved in barrier function to PI-mediated downregulation. Importantly, effects were detectable in a concentration range typi-cally used for experiments with highly susceptible multiple myeloma cells (27,28), that is, at concentrations below the maximum plasma concentration achieved in therapeutic settings (7).…”

Section: Bortezomib Acts Directly On the Skin To Diminish Expression mentioning

confidence: 99%

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Opposing effects on immune function and skin barrier regulation by the proteasome inhibitor bortezomib in an allergen‐induced eczema model

Mudnakudu-Nagaraju

Babina

Worm

2013

Experimental Dermatology

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Proteasome inhibition (PI) has been reported to interfere with antibody-driven autoimmune diseases. The impact of PI on the allergic immune response and on skin diseases like atopic dermatitis (AD) has not been thoroughly explored, however. Here, we examined whether the PI bortezomib interferes with the allergic immune response and the severity of AD by using an established mouse model of allergen-driven dermatitis, to which bortezomib was applied after the establishment of systemic sensitization to ovalbumin. The treatment indeed resulted in a remarkable decrease in total and allergen-specific plasma cells/antibody-secreting cells, as evidenced by flow cytometry and ELISpot, respectively. This was accompanied by rapid reductions in serum antibody titres, including a prominent reduction of the IgE isotype. CD4+ and CD8+ cells were greatly diminished in lesional skin on immunohistological staining. The impressive effects at the level of immune modulation did not result in any improvement in the eczema, however. Following up on this unexpected result, we found that the skin itself was susceptible to bortezomib, by which it was instructed to lower the expression of critical skin barrier genes, especially transglutaminase-1 and filaggrin. Together, bortezomib eliminates plasma cells and decreases immunoglobulin responses, including allergenic IgE. Although anti-inflammatory effects are detectable in the skin, counter-regulatory effects from PI on resident skin cells likely undermine improvement in the eczema. These results caution against the therapeutic use of bortezomib for inflammatory skin disorders, which are characterized by inherently impaired barrier function, especially AD.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Bortezomib Acts Directly On the Skin To Diminish Expression mentioning

confidence: 99%

See 1 more Smart Citation

Opposing effects on immune function and skin barrier regulation by the proteasome inhibitor bortezomib in an allergen‐induced eczema model

Mudnakudu-Nagaraju

Babina

Worm

2013

Experimental Dermatology

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“…His introduction to Pearson's work probably came after he was appointed in 1905 to the position of statistician in the College of Agriculture at the University of Illinois. In 1907 Rietz wrote the statistical appendix to a book on the breeding of domestic animals and plants written by his dean at the College of Agriculture (Davenport, 1907). The appendix shows that Rietz had read at least some of Pearson's work relating to the normal distribution and correlation.…”

Section: The Years Before 1920mentioning

confidence: 99%

Karl Pearson's Influence in the United States

Bellhouse¹

2009

Int Statistical Rev

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Karl Pearson, the founder of mathematical statistics, was the leading statistical researcher from the 1890s up to about 1920. His interests were wide-ranging and so his impact on statistics in the United States was also wide-ranging. Many American researchers came to University College London to study with him. Others studied his work from afar. In the United States, Pearsonian statistics first penetrated the academic landscape in biology. This was soon followed by the fields of economics and psychology. It was not until relatively late in Pearson's career that several American mathematicians took up statistics as a serious research topic. Copyright (c) 2009 The Author. Journal compilation (c) 2009 International Statistical Institute.

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“…The term thremmatology, derived from the Greek word thremma, i.e . a thing bred, was proposed by RAY LANCASTER to cover the principles and practices concerned in the improvement of domesticated animals and plants (53) .…”

Section: The Need For Text Ooks and Manuals In The Field Of Plant Reementioning

confidence: 99%

Old and new books dealing with general plant breeding

Haan

1958

Euphytica

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In this article a survey is given of old and new books on general plant breeding . They cover a period of some 60 years . A total of 220 titles has been mentioned . The survey has been subdivided in 17 groups according to language ; a comment on most groups is given .An approximately equal number of books has been published in English and in German . It can be stated that about half of the total have been published in other languages. Most books in German are written by German authors ; the majority of books in English are of American origin .Textbooks supply the needs of instruction on plant breeding and are also popular among plant breeders .

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Principles of breeding; a treatise on thremmatology or the principles and practices involved in the economic improvement of domesticated animals and plants, by E. Davenport ... with appendix by H. L. Rietz.

Cited by 3 publications

References 0 publications

Opposing effects on immune function and skin barrier regulation by the proteasome inhibitor bortezomib in an allergen‐induced eczema model

Opposing effects on immune function and skin barrier regulation by the proteasome inhibitor bortezomib in an allergen‐induced eczema model

Karl Pearson's Influence in the United States

Old and new books dealing with general plant breeding

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