Principles of Antimicrobial Drug Action

Edwards, David I.

doi:10.1007/978-1-349-16360-1_2

Cited by 9 publications

(4 citation statements)

References 10 publications

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“…The antibacterial action of vancomycin is due to complexing with the pentapeptide precursor of peptidoglycan biosynthesis. Binding of the antibiotic requires that the peptide precursor have five amino acids and that the terminal pair be D-alanyl-D-alanine (4,6,17). Our results show that, in the case of one strain at least, resistance to vancomycin does not depend on its inactivation.…”

Section: Discussionmentioning

confidence: 69%

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Common occurrence of plasmid DNA and vancomycin resistance in Leuconostoc spp

Orberg¹,

Sandine²

1984

Appl Environ Microbiol

124

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Resistance to vancomycin permitted detection, in a culture of Streptococcus cremoris 290PC, of a contaminant gram-positive coccus. Morphological and physiological characteristics indicated that this bacterium was a strain of Leuconostoc sp., designated P0184. This strain contained four plasmid species, which were distinct from those harbored by S. cremoris 290PC. Antibiotic disk susceptibility tests indicated that Leuconostoc sp. strain P0184 was also resistant to sulfathiazole and trimethoprim and susceptible to 17 other antimicrobials. The MIC of vancomycin for this strain was >2,000 ,ug/ml, and resistance did not depend on drug inactivation. Leuconostoc sp. strain P0184 produced a substance which was inhibitory to S. cremoris U134, but not to S. lactis ATCC 11454. Five other leuconostocs produced substances with antibacterial activity. Of 18 strains of Leuconostoc sp., 14 were resistant to at least 500 jig of vancomycin per ml, including four L. oenos strains which harbored no plasmid DNA in the 1to 76-megadalton range. Twelve Leuconostoc sp. strains contained at least one plasmid species in this mass range. These findings are discussed from the physiological, taxonomical, and ecological standpoints and with regard to their potential applications.

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Section: Discussionmentioning

confidence: 69%

“…Mycobacteria, molds, and yeasts are unsusceptible to vancomycin (10,17). Among the susceptible bacterial species, resistant mutants are very rare or nonexistent (4,13).…”

mentioning

confidence: 99%

Common occurrence of plasmid DNA and vancomycin resistance in Leuconostoc spp

Orberg¹,

Sandine²

1984

Appl Environ Microbiol

124

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“…1985;Umiel and Goldner 1976). Streptomycin binds to the 3 0 S ribosomal subunit of procaryotic-like ribosomes, inhibits polypeptide synthesis and causes misreading of the genetic code (Davis et al 1974;Gorini and Davies 1968;Edwards 1980). Single base-pair changes leading to streptomycin resistance were mapped to positions in the rps12 and/or 16S rRNA genes of the chloroplast genome in Chlamydomonas reinhardtii (Lemieux et al 1984;Lemieux and Lee 1987;Gauthier et al 1988), Euglena gracilis (Montandon 1985) and Nicotiana taxa (Fromm et al 1987(Fromm et al , 1989Etzold et al 1987).…”

Section: Offprint Requests To: Ce Jansenmentioning

confidence: 99%

Induction of streptomycin resistance in the wild tomato Lycopersicon peruvianum

et al. 1990

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A protoplast mutagenesis and cell selection system was used for the isolation of streptomycin resistant Lyeopersieon peruvianum colonies. Protoplasts were treated with the mutagen N-nitroso-methylurea and could be regenerated into fertile plants, carrying the streptomycin resistant character. Several classes of streptomycin resistance could be distinguished. Reciprocal crosses between streptomycin resistant and sensitive plants showed a non-Mendelian transmission of the resistance trait. Streptomycin resistance is the first selectable and maternally inherited cell organelle marker described in tomato.

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“…Another factor that caused the decrease in V. harveyi was due to the presence of an antibiotic compound produced by P. diminuta, namely 2,4 diacetylploroglucinol. This compound functions as an antibiotic whose role is almost the same as the bacteriocin compound, namely inhibiting the formation of cell walls, inhibiting the formation of nucleic acids, and forming pores in the target cell membrane (Williams et al, 1996;Chotiah, 2013). In addition, the antibiotic compound 2,4 diacetylploroglucinol causes lysis and displays antiviral activity against DNA and RNA viruses with envelopes (Brazelton et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

Antagonism Pseudomonas diminuta on The Growth of Vibrio harveyi with Mix Culture Method

Hastuti Satyantini, Ir., M.Si,

Mubarak,

Subekti

2023

JAFH

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One of the obstacles often encountered in white shrimp farming is the presence of bacterial diseases caused by Vibrio group bacteria. One of the efforts to control Vibriosis is by using antagonistic bacteria as biocontrol agents, one of which is using Pseudomonas diminuta. In this study Pseudomonas diminuta and Vibrio harveyi were co-cultured with the aim of determining the optimal density and effective incubation time of P. diminuta which could provide the highest inhibition of V. harveyi growth. This study used a completely randomized design with six treatments P0 (P. diminuta 105 CFU/ml), P1 (V. harveyi 106 CFU/ml), P2 (P. diminuta 105 CFU/ml+V. harveyi 106 CFU/ml), P3 (P. diminuta 106 CFU/ml+V. harveyi 106 CFU/ml), P4 (P. diminuta 107 CFU/ml+V. harveyi 106 CFU/ml), P5 (P. diminuta 108 CFU/ml+V. harveyi 106 CFU/ml). The results of this study showed that P2, P3, P4 and P5 had decreased growth of V. harveyi when compared to control P1 (V.harveyi 106 CFU/ml). The decrease in the growth of V. harveyi occurred at the 8th to 48th hour. V. harveyi in P3 (2.72 × 108 CFU/ml), P2 (2.80 × 108 CFU/ml), P4 (2.96 × 108 CFU/ml) and P5 (2.90 × 108 CFU/ml) at the 48th hour of incubation was lower than P1 (3, 15×108 CFU/ml). Based on the results of the Duncan test showed that P2, P3, P4 and P5 were significantly different (p <0.05) from P1. From this study it was concluded that administration of P. diminuta at a density of 106 CFU/ml was able to reduce the growth of V. harveyi. The greatest decrease in the growth of V. harveyi occurred at the 48th hour.

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Principles of Antimicrobial Drug Action

Cited by 9 publications

References 10 publications

Common occurrence of plasmid DNA and vancomycin resistance in Leuconostoc spp

Common occurrence of plasmid DNA and vancomycin resistance in Leuconostoc spp

Induction of streptomycin resistance in the wild tomato Lycopersicon peruvianum

Antagonism Pseudomonas diminuta on The Growth of Vibrio harveyi with Mix Culture Method

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