Principles governing the integration of landmark and self-motion cues in entorhinal cortical codes for navigation

Campbell, Malcolm; Ocko, Samuel A.; Mallory, Caitlin S.; Low, Isabel I. C.; Ganguli, Surya; Giocomo, Lisa M.

doi:10.1038/s41593-018-0189-y

Cited by 156 publications

(212 citation statements)

References 53 publications

Supporting

Mentioning

191

Contrasting

Order By: Relevance

“…Currently, immersive VR does not allow the concurrent recording of neural data. The contribution of locomotor cues to the experience of navigation in general has been emphasized previously (Taube et al, 2013) and recent studies in rodents have used gain manipulations in VR to emphasize the contributions of locomotor cues to grid cell firing specifically (Campbell et al, 2018;Chen et al, 2019). Having established the impact of environmental geometry on human spatial cognition, an exciting question for future research would be to combine manipulations of environmental geometry with neuroimaging techniques such as fMRI to study the deformations of the cognitive map we describe here in the brain.…”

Section: Discussionmentioning

confidence: 98%

Deforming the metric of cognitive maps distorts memory

Bellmund

Ruiter

Nau

et al. 2018

Preprint

View full text Add to dashboard Cite

Environmental boundaries anchor cognitive maps that support memory. However, trapezoidal boundary geometry distorts the regular firing patterns of entorhinal grid cells proposedly providing a metric for cognitive maps. Here, we test the impact of trapezoidal boundary geometry on human spatial memory using immersive virtual reality. Consistent with reduced regularity of grid patterns in rodents and a grid-cell model based on the eigenvectors of the successor representation, human positional memory was degraded in a trapezoid compared to a square environment; an effect particularly pronounced in the trapezoid's narrow part. Congruent with spatial frequency changes of eigenvector grid patterns, distance estimates between remembered positions were persistently biased; revealing distorted memory maps that explained behavior better than the objective maps. Our findings demonstrate that environmental geometry affects human spatial memory similarly to rodent grid cell activity -thus strengthening the putative link between grid cells and behavior along with their cognitive functions beyond navigation.

show abstract

Section: Discussionmentioning

confidence: 98%

Deforming the metric of cognitive maps distorts memory

Bellmund

Ruiter

Nau

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…found to sharpen spatial tuning of neurons (Campbell et al, 2018;Gothard & Skaggs, 470 1996; Knierim et al, 1995). 471…”

mentioning

confidence: 99%

Representation of Visual Landmarks in Retrosplenial Cortex

Fischer

Soto-Albors

Buck

et al. 2019

Preprint

View full text Add to dashboard Cite

8The process by which visual information is incorporated into the brain's spatial framework 9to represent landmarks is poorly understood. Studies in humans and rodents suggest that 10 retrosplenial cortex (RSC) plays a key role in these computations. We developed an RSC-11 dependent behavioral task in which head-fixed mice learned the spatial relationship 12 between visual landmark cues and hidden reward locations. Two-photon imaging 13revealed that these cues served as dominant reference points for most task-active 14neurons and anchored the spatial code in RSC. Presenting the same environment but 15 decoupled from mouse behavior degraded encoding fidelity. Analyzing visual and motor 16responses showed that landmark codes were the result of supralinear integration. 17Surprisingly, V1 axons recorded in RSC showed similar receptive fields. However, they 18 were less modulated by task engagement, indicating that landmark representations in 19RSC are the result of local computations. Our data provide cellular-and network-level 20insight into how RSC represents landmarks. 21 22

show abstract

“…Hippocampal spatial representations are affected by a number of non-visual cues, amongst which idiothetic information (i.e. the distance traveled in the environment) is fundamental (Campbell et al, 2018;Chen et al, 2013Chen et al, , 2019Gothard et al, 1996;Jayakumar et al, 2019;Ravassard et al, 2013). We next asked whether idiothetic cues could also affect representations of space in visual cortex.…”

Section: Spatial Representations In V1 and Ca1 Are Influenced By Distmentioning

confidence: 99%

Modulation of visual cortex by hippocampal signals

Fournier

Saleem

Diamanti

et al. 2019

Preprint

View full text Add to dashboard Cite

Neurons in primary visual cortex (V1) are influenced by the animal's position in the environment and encode positions that correlate with those encoded by hippocampus (CA1). Might V1's encoding of spatial positions be inherited from hippocampal regions? If so, it should depend on non-visual factors that affect the encoding of position in hippocampus, such as the physical distance traveled and the phase of theta oscillations. We recorded V1 and CA1 neurons while mice ran through a virtual corridor and confirmed these predictions. Spatial representations in V1 and CA1 were correlated even in the absence of visual cues. Moreover, similar to CA1 place cells, the spatial responses of V1 neurons were influenced by the physical distance traveled and the phase of hippocampal theta oscillations. These results reveal a modulation of cortical sensory processing by non-sensory estimates of position that might originate in hippocampal regions.

show abstract

Principles governing the integration of landmark and self-motion cues in entorhinal cortical codes for navigation

Cited by 156 publications

References 53 publications

Deforming the metric of cognitive maps distorts memory

Deforming the metric of cognitive maps distorts memory

Representation of Visual Landmarks in Retrosplenial Cortex

Modulation of visual cortex by hippocampal signals

Contact Info

Product

Resources

About