Principles and issues in radiological ecological risk assessment

Does uranium exposure induce genotoxicity in the teleostean Danio rerio? First experimental results

“…They were daily supplied with standard fish pellets (1% of their body mass per day) and kept at 25°C in artificial water equilibrated by air-bubbling and continuously renewed by means of a flowthrough water system. Ion concentrations in synthetic water were as follows: 6.26 mg/L K + , 11.5 mg/L Na + , 4.74 mg/L Mg 2+ , 11.6 mg/L Ca 2+ , 32.4 mg/L Cl -, 31.0 mg/L NO 3 -, 9.61 mg/L SO 4 2-, 0.45 mg/L CO 3 2-. The pH was regulated at a value of 6.5 by the addition of HCl via peristaltic pumps controlled by pH stats (Consort R301, Illkirch, Belgium)…”

“…Considering uranium chemical characteristics, as any heavy metal, this radioelement is a potent genotoxic compound via the formation of oxidative DNA damages due to the redox chemistry of transition metals and their ability to activate oxygen species in the course of redox reactions [2] [3]. In the same way, its radiological properties being characterized by ionising radiations (mainly via the emission of α particles) can enhance this free radical production [4]. Thereby there is a need of knowledge of the understanding of U-living organisms interactions to provide useful tools for predicting possible genotoxic effects of environmental uranium exposure.…”

Utilização De Peixes Como Biomonitor Para Fins De Radioproteção Ambiental Em Ecossistemas Aquáticos Continentais. Um Modelo Conceitual

“…É o caso de Jones e colaboradores (Jones et al 2003), que além da ERA utilizam modelos dosimétricos analisando as vias criticas de exposição. Kumlad et al (2006) focam os fatores de bioacumulação e coefi ciente de partição e analisam a importância desses fatores no desenvolvimento de um modelo não-mecanicista.…”

User's guide, version 1 RESRAD-BIOTA : a tool for implementing a graded approach to biota dose evaluation.

“…Additional details can also be found in published papers by Jones et al (2003) and Higley et al (2003 a, b, c).…”