Principles and applications of thermal biosensors

Ramanathan, Kumaran; Danielsson, Bengt

doi:10.1016/s0956-5663(01)00124-5

Cited by 216 publications

(93 citation statements)

References 48 publications

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“…For many years, a large number of biosensors have been constructed and implemented in various applications, ranging from public health, microbial ecology to environmental monitoring and food safety 35 . Microbial biosensors can be classified according to the type of signal that is detected after the interaction with the analyte including electrochemical 39 , thermal 40 , acoustic 41 and optical biosensors 42 .…”

Section: Synthetic Biosensors and Environmental Qualitymentioning

confidence: 99%

The potential of synthetic biology for improving environmental quality and human health in developing countries

Niño

Islam

2017

revsal

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Environmental quality is a major factor in global health that mainly affects the poorest populations. Vectorborne diseases, climate change, pollution and unintentional poisonings are recognized as the primary causes of environmental diseases burden in developing countries. The development and implementation of new technologies to reduce the impact of these risk factors on health in developing countries is a priority in the current research. In this regard, synthetic biology, a nearly new research area, has initiated a big revolution through the de novo design or rewiring of biological components, organisms, and functions with the aim to reduce the adverse effects of environmental risk factors on human health. Despite synthetic biology is well recognized for being a multidisciplinary area where biotechnologist, biologist, physicists, mathematicians and engineers play together, its integration with public health and other social sciences seems to be of relevance to apply these technologies into a practical context. In this review, we discuss the major advances in synthetic biology with potential to improve environmental quality and human health in developing countries.Keywords: Public health. Synthetic biology. Developing countries. Environmental diseases. RESUMENLa calidad ambiental es reconocida como uno de los factores con mayor impacto sobre la salud humana principalmente en los países en vías de desarrollo. Las enfermedades transmitidas por vectores, el cambio climático, la contaminación y las intoxicaciones no intencionales han sido reportados como las principales causas de enfermedades ambientales en estos países. El desarrollo y la implementación de nuevas tecnologías encaminadas a reducir el impacto de estos factores ambientales en la salud es una prioridad de la investigación actual. En ese sentido, la biología sintética ha iniciado una gran revolución al permitir el diseño de novo y el mejoramiento de diversos componentes biológicos, organismos y funciones biológicas que tienen el potencial de reducir los efectos adversos de estos factores en la salud humana de una manera más eficiente y económica. A pesar de que la biología sintética es reconocida como un área multidisciplinaria donde biotecnólogos, biólogos, físicos, matemáticos e ingenieros unen sus esfuerzos, su integración con el área de la salud pública y las ciencias sociales es muy importante para llevar estas tecnologías a la práctica. En esta revisión, nosotros discutimos los más importantes avances en biología sintética y su potencial para mejorar la calidad ambiental y la salud humana en países en vías de desarrollo.

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Section: Synthetic Biosensors and Environmental Qualitymentioning

confidence: 99%

The potential of synthetic biology for improving environmental quality and human health in developing countries

Niño

Islam

2017

revsal

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“…Therefore, depending on the technique used in signal transducer, biosensors might be divided into optical, mass, bioluminescence, electrochemical, and thermal sensors. [7][8][9][19][20][21] Definitions, substrates, responses, detection limits, advantages, and limitations of different types of biosensors such as electrochemical biosensors or bioluminescence biosensors are summarized in the following paragraphs. Optical biosensors are particularly attractive for the application of direct detection systems.…”

Section: ·1 Performance Of Biosensorsmentioning

confidence: 99%

“…The majority of the heat evolved in the enzymatic reactions is lost to the surrounding media without being detected; the lost heat lowers the sensitivity of the thermal biosensors. 19 Piezoelectric biosensors operate on the principle of coating the surface of the biosensor with a selectively binding biologically active substance. 18,21 The coated surface is placed in a solution containing analytes that bind to the binding substance.…”

Section: ·1 Performance Of Biosensorsmentioning

confidence: 99%

Recent Developments, Characteristics, and Potential Applications of Electrochemical Biosensors

2004

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The objective of this study is to analyze the technical importance, performance, techniques, advantages, and disadvantages of the biosensors in general and of the electrochemical biosensors in particular. A product of reaction diffuses to the transducer in the first generation biosensors (based on Clark biosensors). The mediated biosensors or second generation biosensors use specific mediators between the reaction and the transducer to improve sensitivity. The second generation biosensors involve two steps: first, there is a redox reaction between enzyme and substrate that is reoxidized by the mediator, and eventually the mediator is oxidized by the electrode. No normal product or mediator diffusion is directly involved in the third generation biosensors, direct biosensors. Based on the type of transducer, current biosensors are divided into optical, mass, thermal, and electrochemical sensors. They are used in medical diagnostics, food quality controls, environmental monitoring, and other applications. These biosensors are also grouped under two broad categories of sensors: direct and indirect detection systems. Moreover, these systems could be further grouped into continuous or batch operation. Therefore, amperometric biosensors and their current applications are focused on more in detail since they are the most commonly used biosensors in monitoring and diagnosing tests in clinical analysis. Problems related to the commercialization of medical, environmental, and industrial biosensors as well as their performance characteristics, their competitiveness in comparison to the conventional analytical tools, and their costs determine the future development of these biosensors.

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“…The development of large-scale biosensor arrays composed of highly miniaturized signal transducer elements, for example, enables the real-time parallel monitoring of multiple species and is an important driving force in biosensor research [144]. In clinical diagnosis, simultaneous determination of multiple analytes has been a great challenge [149]. Multichannel biosensors are required for direct detection in high-throughput screening systems in the search for new pharmaceuticals.…”

Section: Multianalyte Determinationmentioning

confidence: 99%

Biosensors for environmental applications: Future development trends

Rodríguez-Mozaz

Marco

Alda

et al. 2004

Pure and Applied Chemistry

195

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Biosensors can be excellent analytical tools for monitoring programs working to implement legislation. In this article, biosensors for environmental analysis and monitoring are extensively reviewed. Examples of biosensors for the most important families of environmental pollutants, including some commercial devices, are presented. Finally, future trends in biosensor development are discussed. In this context, bioelectronics, nanotechnology, miniaturization, and especially biotechnology seem to be growing areas that will have a marked influence on the development of new biosensing strategies in the next future.

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Principles and applications of thermal biosensors

Cited by 216 publications

References 48 publications

The potential of synthetic biology for improving environmental quality and human health in developing countries

The potential of synthetic biology for improving environmental quality and human health in developing countries

Recent Developments, Characteristics, and Potential Applications of Electrochemical Biosensors

Biosensors for environmental applications: Future development trends

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