Principles and application of biosensors in microbiology

Higgins, I. J.; Swain, Anup Kumar; Turner, Anthony

doi:10.1111/j.1365-2672.1987.tb03615.x

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…More recently, it has been possible to use a ferrocene derivative as an artificial redox carrier to shuttle electrons from glucose oxidase to a carbon electrode, thus making the device largely independent of oxygen concentrations (Higgins and Boldot, 1992). Enzyme electrodes are also commercially available to monitor cholesterol, triglycerides, lactate, acetate, oxalate, methanol, ethanol, creatine, ammonia, urea, amino acids, carbohydrates and penicillin (Higgins et al, 1987;Luong et al, 1988;Higgins and Boldot, 1992).…”

Section: Enzyme and Microbial Electrodesmentioning

confidence: 99%

Instrumentation and Control

Stanbury

1995

Principles of Fermentation Technology

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Section: Enzyme and Microbial Electrodesmentioning

confidence: 99%

Instrumentation and Control

Stanbury

1995

Principles of Fermentation Technology

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“…The trajectory of healthcare toward personalized medicine is realizing medical tests that are widely accessible, faster and more convenient, and low-cost with biosensors. These instruments selectively identify and sensitively quantify bioanalytes from a patient or environmental sample (21)(22)(23)(24). An important aspect of biosensor operation is the sensitive quantification of bioanalyte concentration, after it is recognized, through transduction.…”

Section: Introductionmentioning

confidence: 99%

Point-of-Care Diagnostics: Molecularly Imprinted Polymers and Nanomaterials for Enhanced Biosensor Selectivity and Transduction

Denmark

Mohapatra

2020

The EuroBiotech Journal

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Significant healthcare disparities resulting from personal wealth, circumstances of birth, education level, and more are internationally prevalent. As such, advances in biomedical science overwhelmingly benefit a minority of the global population. Point-of-Care Testing (POCT) can contribute to societal equilibrium by making medical diagnostics affordable, convenient, and fast. Unfortunately, conventional POCT appears stagnant in terms of achieving significant advances. This is attributed to the high cost and instability associated with conventional biorecognition: primarily antibodies, but nucleic acids, cells, enzymes, and aptamers have also been used. Instead, state-of-the-art biosensor researchers are increasingly leveraging molecularly imprinted polymers (MIPs) for their high selectivity, excellent stability, and amenability to a variety of physical and chemical manipulations. Besides the elimination of conventional bioreceptors, the incorporation of nanomaterials has further improved the sensitivity of biosensors. Herein, modern nanobiosensors employing MIPs for selectivity and nanomaterials for improved transduction are systematically reviewed. First, a brief synopsis of fabrication and wide-spread challenges with selectivity demonstration are presented. Afterward, the discussion turns to an analysis of relevant case studies published in the last five years. The analysis is given through two lenses: MIP-based biosensors employing specific nanomaterials and those adopting particular transduction strategies. Finally, conclusions are presented along with a look to the future through recommendations for advancing the field. It is hoped that this work will accelerate successful efforts in the field, orient new researchers, and contribute to equitable health care for all.

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