Principales modelos experimentales de traumatismo craneoencefálico: de la preclínica a los modelos in vitro

Sempere, L.; Rodríguez-Rodríguez, A.; Boyero, Laura; Egea-Guerrero, Juan José

doi:10.1016/j.medin.2018.04.012

Cited by 6 publications

(6 citation statements)

References 74 publications

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“…TBI represents a pathology that significantly contributes to the increase of morbidity and mortality worldwidely, both in adults and in children [ 12 ]. In the European Union, there are recorded over one million hospitalizations due to TBI [ 13 , 14 ].…”

Section: ⧉ Discussionmentioning

confidence: 99%

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Experimental model for the study of traumatic brain injury

Dumitru

Zorilă

Ţolescu³

et al. 2021

Rom J Morphol Embryol

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Traumatic brain injury (TBI) represents a public healthcare problem and a major economic burden, all over the world. It is estimated that every year, on the globe, there occur about two million severe TBI and over 42 million mild TBI. The main causes of TBI in civil population are fallings, followed by car accidents. In the last decades, the accelerated development of car industry and the poor development of traffic infrastructure in low- and average-income countries led to an increasing number of brain injuries, this becoming a major problem for medical health systems. According to some studies, approximately 1.35 million people die every year because of car accidents. In the last four decades, these types of injuries started to be studied in order to understand the lesion mechanisms for developing new safety equipment that may be installed on vehicles. The device presented by us for causing a TBI in a lab rat (mechanical pendulum) allows the performance of several major types of TBI, according to the kinetic energy, exposure area, contact surface, etc. The impact energies obtained by the device we presented may vary on a large scale, from less than 1 J up to 10 J, according to its weight, launching angle and impact head shape, thus being obtained minor, moderate or severe TBI.

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Section: ⧉ Discussionmentioning

confidence: 99%

“…For obtaining a TBI, there were conceived and used several types of devices: pneumatic, electromagnetic, mechanic ones (by free falling, arch, projectile, etc.) [ 3 , 14 ].…”

Section: ⧉ Discussionmentioning

confidence: 99%

Experimental model for the study of traumatic brain injury

Dumitru

Zorilă

Ţolescu³

et al. 2021

Rom J Morphol Embryol

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“…The results also showed an inflammation lasting from the first hour of the first day after the head injury. Additionally, there was evidence of secondary brain injury in the brain [ [18] , [19] , [20] ].…”

Section: Discussionmentioning

confidence: 99%

Modification of the Marmarou model in developing countries

Nasution

Islam

Hatta

et al. 2020

Annals of Medicine and Surgery

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Introduction Head injury is an injury or wound of the brain tissue due to external forces; it can cause a decrease or change in the status of consciousness. Many head injury models have used mice as experimental animals; the Marmarou model is the most famous and the most widely-used diffuse brain injury model. In this study, we slightly modified the Marmarou model. The purpose of this study is to help researchers examining head injuries in mice, especially those in developing countries who have limited facilities and infrastructure. Methods This experimental research uses animals models ( Rattus novergicus , strain Sprague Dawley) that fit several criteria, including male, aged 10–12 weeks, and body weight of 200–300 g. This study involves a slight modification on the tube used, with a 20 cm-long weight of 20 g. The blood samples for the following assays of ELISA and brain tissue samples were collected at 24 h and 4, 5, 6, and 7 days post-trauma. Results A significant effect on the brain was seen with the Marmarou model modification, at a mass weight of 20 g and height of 20 cm, with 0.04 J energy produced. Changes were also seen in the histological features of brain tissue and the serum levels of AQP-4, F2 IsoPs, MPO, and VEGF from 24 h until 7 days after trauma. Conclusion This report describes the development of an experimental head injury approach modifying the Marmarou model that is able to produce a diffuse brain injury model in mice.

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“…If this is not the case, the damage mechanisms and potential protection mechanisms generated are valid only for the model, but not for pathology (Figure 1). 35…”

Section: Experimental Models In Memory and Learning Impairmentmentioning

confidence: 99%

“…75 Dietary supplementation with thymol improved brain state by induction of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) respectively and the proportion of phospholipids in the brain of aging rat. 76 In addition, thymol inhibits cognitive decline caused by increased levels of Aβ peptide or cholinergic hypofunction in rats treated with Aβ (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) or scopolamine, these effects are attributed to its antioxidant, anti-inflammatory and anticholinergic esterase properties. 77 Also, it improves spatial memory in Morris' maze test in a rat-induced AD model that received consumption of a high-fat diet.…”

Section: Mechanisms Of Action Of Essential Oilsmentioning

confidence: 99%

Potential Neuroprotective Activity of Essential Oils in Memory and Learning Impairment

Silva-Correa¹,

Campos-Reyna²,

Torre³

et al. 2021

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Learning and memory are linked, but they are different. Learning is a process by which knowledge about the environment is acquired and memory is the process by which knowledge is encoded, consolidated, stored and then retrieved. [10][11] Coding involves processes by which newly learned information is received when it is for the first time.Consolidation is a process that modifies newly stored and still labile information to make it more stable for long-term storage. Consolidation involves the expression of genes and the synthesis of new proteins, resulting in structural changes that store memory in a stable way over time. Storage refers to mechanisms and places that retain information over time. Recovery are processes that enable the retrieval and use of stored information. [12][13][14] Various types of memory have been proposed over the years,

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Principales modelos experimentales de traumatismo craneoencefálico: de la preclínica a los modelos in vitro

Cited by 6 publications

References 74 publications

Experimental model for the study of traumatic brain injury

Experimental model for the study of traumatic brain injury

Modification of the Marmarou model in developing countries

Potential Neuroprotective Activity of Essential Oils in Memory and Learning Impairment

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