State such as a smooth, red tongue, peripheral neuritis or cheilosis. Although anemia was common, it was not a necessary concomitant. In 14 cases in which data were available, no consistent relationship to reduced or altered serum proteins or deranged liver function was suggested. Three weeks of intensive therapy with thiamine hydrochloride, nicotinic acid, riboflavin or brewers' yeast caused no observable change ; yet 2 patients with Laënnec's cirrhosis, who responded favorably to a high carbohydrate and high vitamin regimen, showed disappearance of palmar erythema after about a four months period had elapsed.Examination of the lesions demonstrated blanching on pres-' sure, with more rapid return of color than is true in the normal hand. Fading of the erythema did not take place with elevation of the hand, and definite flushing synchronous with the arterial pulse was seen when the color was partially obliterated by pressure with a glass slide. With the inconstant exception of patients with rheumatoid arthritis, whose moist palms felt cooler as the result perhaps of increased vaporization, hands with palmar erythema were often unusually warm to the touch. In 5 cases no change in appearance could be noted when a blood pressure cuff was placed on the arm between systolic and diastolic levels, and only slight fading took place when pressures above systolic readings were introduced with the arms elevated vertically. If the erythema was reduced by massaging the involved areas while the cuff was inflated, full color reappeared as the pressure was lowered tj 40-50 mm. of mercury. In addition to this suggestive evidence of increased arteriolar flow, capillaries were found to be more numerous and dilated on direct microscopic examination. Immersion of the hands for three minutes in water at 3 or at 37 C had no effect. Epinephrine (0.5 cc. of 1 : 1,000 solution), given hypodermically to 3 patients, produced slight fading in color, and 0.3 cc. injected into the brachial artery caused prompt and profound blanching of the hand on the side of the injection and minimal alteration on the opposite side. Atropine subcutaneously or by vein resulted in no change, nor was the erythema affected by ulnar nerve procaine block or electrical stimulation of the same nerve in these 3 cases.Pathologic e. animation of the lesions of 2 patients who died of cirrhosis showed no microscopic vascular or other abnormalities in skin or subcutaneous tissues. SUMMARY A palmar erythema, a peripheral vascular dilatation involving chiefly the eminences of the palms and digits, has been observed. Although its cause remains obscure, it is usually associated with chronic disease and prolonged dietary insufficiency or deficiency states.The problem of the treatment and care of patients with delirium tremens is well known. Usually large quantities of sedatives, drastic purgatives and frequent spinal taps are used. The patient remains strapped in bed, straining against his bonds and raising considerable disturbance. The difficulty of treating associated conditi...