Estimation of Total Body Sodium by Isotopic Dilution. I. Studies on Young Adults 123

Forbes, Gilbert B.; Perley, Anne M.

doi:10.1172/jci102472

Cited by 109 publications

(47 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The chemical data are summarized in Table II (21) for human bone, and our calcium/sodium ratios agree well with the (22). On the other hand, Shohl's (6) figure for human bone as containing 79 mEq.…”

Section: B Resultssupporting

confidence: 82%

Electrolyte Composition of Bone and the Penetration of Radiosodium and Deuterium Oxide Into Dog and Human Bone 12

Edelman¹,

James²,

Baden³

et al. 1954

J. Clin. Invest.

133

View full text Add to dashboard Cite

Section: B Resultssupporting

confidence: 82%

Electrolyte Composition of Bone and the Penetration of Radiosodium and Deuterium Oxide Into Dog and Human Bone 12

Edelman¹,

James²,

Baden³

et al. 1954

J. Clin. Invest.

133

View full text Add to dashboard Cite

“…Following 24 h of equilibration, during which time the urine was collected for measurement of the secretion rate of aldosterone and the excretion of labeled sodium, the specific activity of the plasma sodium and the value for the exchangeable sodium were measured by the isotope dilution method [18].…”

Section: Sodiummentioning

confidence: 99%

“…Our patients (case nos. 15,18,21, and 22) went into negative sodium balance on a low salt diet and could not conserve Na,. Nevertheless, the improvement on the state occurring in the early months and years of life was quite spectacular.…”

Section: The 'Recovery'mentioning

confidence: 99%

Exchangeable Sodium and Aldosterone Secretion in Children with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

1970

View full text Add to dashboard Cite

Aldosterone secretion rates (ASR) and exchangeable body sodium (Na,) have been measured simultaneously in 25 cases of congenital adrenal hyperplasia (CAH) with and without salt loss, both during normal and during low salt intake. The degree of 21 -hydroxylase deficiency was assessed from the cortisol secretion rate (CSR) and urinary excretion of pregnanetriol and 11-ketopregnanetriol. In cases with salt loss, the sodium equilibrium was unstable, even with optimum treatment and increased dietary salt intake. Clinical evidence of salt-losing crisis appeared when 15-25% of Na, was lost. In these subjects, a parallel decrease in ASR and CSR usually occurred. The ASR were somewhat elevated in the nonsalt-losing form. Speculation

show abstract

“…However, the relationship between the 3-hour and 24-hour space determinations in the patients in 8 In studies not included in the present paper paracentesis was performed on six patients five hours after injection of radioactive sodium, the total volume of ascitic fluid withdrawn being, respectively, 1.1 L., 1.3 L., 2.9 L., 4.8 L., 5.7 L., and 9.8 L. Simultaneous sampling of plasma and ascitic fluid at that time showed equilibrium in the first five patients, but not in the sixth. There was no way of knowing how much sooner than five hours equilibration had occurred.…”

Section: 58mentioning

confidence: 99%

Water Distribution in Normal Subjects and in Patients With Laënnec's Cirrhosis

Gilder¹,

Redo²,

Barr³

et al. 1954

J. Clin. Invest.

View full text Add to dashboard Cite

The development of ascites and edema in patients with Laennec's cirrhosis is believed by some to be due to a deranged hormonal balance which results in salt and water retention (1-5). The present investigation analyzes the components of total body water in 22 control subjects and 15 patients with Laennec's cirrhosis to ascertain the distribution of the retained salt and water. METHODSThe control subjects were patients on the surgical wards for minor procedures which influence water and electrolyte balance minimally. The patients with cirrhosis were admitted for therapeutic operative procedures, observation, or treatment of ascites.Plasma volume was measured by the method of Gibson, Evelyn, and Gregerson using the dye, T-1824, (Evans Blue) (6, 7). Blood volume was calculated from the value of the plasma volume or T-1824 space and the hematocrit. Radioactive sodium was utilized to measure the extracellular space plus the additional space into which sodium presumably passes. Total body water was determined by the dilution of injected deuterium oxide.The patients were in a basal state at the time of the study. After taking a pre-injection blood sample the needle was left in the vein and to it was attached a threeway stopcock, to one arm of which was fastened a syringe containing saline. To the other arm of the stopcock was attached a 50 ml. burette equipped with rubber tubing and adapter which was filled to the adapter with a saline solution containing approximately 70 microcuries of radioactive sodium 1 and 3 ml. of 0.45 per cent dye T-1824 in each 10 ml. The stopcock was opened and about 10 ml. of this solution was allowed to enter by gravity. The exact quantity injected was measured on the burette and the material left in the stopcock and needle washed into the vein with the saline in the syringe. The burette and adapter were then removed, and a weighed 50-ml. syringe con-1 Radioactive sodium received from Brookhaven National Laboratories as the carbonate (Naf?CO,) was first prepared by diluting in sterile saline, neutralizing with the calculated amount of 6 N hydrochloric acid, sterilizing by filtration through an ultrafine sintered glass filter, and boiling on a hot plate for 15 minutes. The 70 microcuries given represents a dosage of about 0.1 roentgen, one-third the accepted tolerance level of 0.3 roentgen per week.taining the deuterium oxide-saline solution 2 was attached.The stopcock was again opened and the deuterium oxide was injected under slight pressure in a period' of about 2 minutes. The deuterium oxide remaining in stopcock and needle was washed into the vein in a manner similar to that of the first solution. The difference between the weights of the full and the empty syringe was taken as the weight of the deuterium oxide solution injected.Ten minutes after the injection of the dye T-1824 and the radioactive sodium, a blood sample was taken for determination of plasma volume. Three hours after the injection a blood sample was taken for measuring sodium and deuterium oxide space. Twenty-four hours a...

show abstract

Estimation of Total Body Sodium by Isotopic Dilution. I. Studies on Young Adults 123

Cited by 109 publications

References 8 publications

Electrolyte Composition of Bone and the Penetration of Radiosodium and Deuterium Oxide Into Dog and Human Bone 12

Electrolyte Composition of Bone and the Penetration of Radiosodium and Deuterium Oxide Into Dog and Human Bone 12

Exchangeable Sodium and Aldosterone Secretion in Children with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

Water Distribution in Normal Subjects and in Patients With Laënnec's Cirrhosis

Contact Info

Product

Resources

About