Principal findings from a multicenter trial investigating the safety of follicular-fluid meiosis-activating sterol for in vitro maturation of human cumulus-enclosed oocytes

Smitz, Johan; Picton, Helen-Mary; Platteau, Peter; Rutherford, Anthony J.; Cortvrindt, R.; Clyde, Julie M; Nogueira, Daniela; Devroey, Paul; Lyby, Karsten; Grøndahl, C.

doi:10.1016/j.fertnstert.2006.10.009

Cited by 31 publications

(15 citation statements)

References 66 publications

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“…But what can be done with frozen ovarian tissue of the leukemia survivor if there happen to have been leukemic cells in that tissue? Culturing that tissue to obtain mature follicles for IVF in these patients is currently the subject of intense research efforts (61)(62)(63). Culturing of primordial follicles may still be a distant goal (64)(65)(66)(67)(68), but progress is now being made with threedimensional culturing of secondary follicles, because one mechanism controlling follicle maturation in the ovarian cortex may be physical pressure and tissue rigidity (69)(70)(71)(72).…”

Section: Discussionmentioning

confidence: 99%

Duration of fertility after fresh and frozen ovary transplantation

Silber

Kagawa²,

Kuwayama³

et al. 2010

Fertility and Sterility

220

163

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Section: Discussionmentioning

confidence: 99%

Duration of fertility after fresh and frozen ovary transplantation

Silber

Kagawa²,

Kuwayama³

et al. 2010

Fertility and Sterility

220

163

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“…First, it may be due to the oocyte susceptibility to the environment during the first meiosis (20). According to a multicenter trial that investigated the safety of follicular fluid meiosis-activating sterol for IVM of human oocytes, both prolonging the culture time from 30 to 36 hours and the 20-mM dose of follicular fluid meiosis-activating sterol increased the aneuploidy rate (21). Second, FSH may increase aneuploidy owing to its effects on microtubule (3,22).…”

Section: Discussionmentioning

confidence: 99%

High follicle-stimulating hormone increases aneuploidy in human oocytes matured in vitro

Peng

Wang

et al. 2011

Fertility and Sterility

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“…Presence of cumulus providing metabolites from glycolysis and follicular fluid meiosis activating sterol (FF-MAS), a sterol intermediate in the cholesterol biosynthetic pathway produced within the follicle in vivo reduced or prevented the incidence of precocious chromatid segregation prior to anaphase II in this model (Cukurcam et al, 2007). Although human oocytes matured with FF-MAS did not have reduced aneuploidy rates compared to in vivo ovulated ones, FF-MAS might have protected oocytes from errors in chromosome segregation induced by the in vitro maturation conditions (Smitz et al, 2007). From these observations it appears that multiple factors may influence fidelity of chromosome segregation in young or aged oocytes.…”

Section: Normal Meiosis I With Syntel Attachment Of Homologs (A) and mentioning

confidence: 91%

Oocyte ageing and its cellular basis

Eichenlaub-Ritter

2012

Int. J. Dev. Biol.

103

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Aneuploidy is extremely high in aged human oocytes. Its cellular origin has been elusive. Trisomy data implicate predominantly meiosis I errors in the genesis of oocyte aneuploidy. Susceptible recombination patterns increase risks for nondisjunction. Cytogenetic analyses of aged human oocytes and embryos from assisted reproduction (ART) suggest that aneuploidy primarily relates to precocious chromatid separation. Oocytes express a spindle assembly checkpoint (SAC), but do not arrest maturation in the presence of improperly attached or single, unattached chromosomes. The SAC may be more permissive by altered gene expression in aged oocytes. Aged oocytes frequently exhibit precocious loss of chromosome cohesion. In experimental models, cohesion cannot be restored once lost, a process possibly occurring during long meiotic arrest. Maternal age, hormonal stimulation, disturbed metabolism, and depletion of the follicle pool contribute to mitochondrial dysfunction, spindle aberrations, and errors in chromosome segregation. Caloric restriction and antioxidants reduce mitochondrial dysfunction and aneuploidy in aged rodent's oocytes. Loss of chromosome cohesion appears to be a major risk factor for aneuploidy by disturbing the sequential separation of homologs and chromatids. A permissive SAC, the presence of risky meiotic exchanges, changes in expression, and failures to resolve improper chromosome attachments, as well as mitochondrial dysfunction may synergistically increase susceptibility to meiotic errors. A healthy life style, mild stimulation and an optimal environment may delay ageing and sustain control over chromosome disjunction, whereas loss of cohesion appears to be irreversible.

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Principal findings from a multicenter trial investigating the safety of follicular-fluid meiosis-activating sterol for in vitro maturation of human cumulus-enclosed oocytes

Cited by 31 publications

References 66 publications

Duration of fertility after fresh and frozen ovary transplantation

Duration of fertility after fresh and frozen ovary transplantation

High follicle-stimulating hormone increases aneuploidy in human oocytes matured in vitro

Oocyte ageing and its cellular basis

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