Primitive neuroectodermal tumor originating from the lung: A case report

Abstract

Abstract. Primitive neuroectodermal tumors (PNETs) are small, round cell tumors that may be classified as peripheral or central, based on their site of origin. PNETs often arise in the soft tissue or bone of young adults. Although not common, PNETs have been described in other organs, including the gonads, kidneys, myocardium and pancreas, but rarely in the lungs without chest wall or pleural involvement. The present study reports a rare case of peripheral PNET (pPNET), which originated in the lung. A 37-year-old female patient presented at Xuzhou Central Hospital (Xuzhou, China) with a history of a dry cough, mild dyspnea and slight pain in the left chest. Histopathological and immunohistochemical analyses permitted the diagnosis of a pPNET. The patient was treated with surgical resection, followed by chemotherapy (including cyclophosphamide, cisplatin and vincristine), radiotherapy and traditional Chinese medicine (including Kanglaite and Shenqi Fuzheng injections). At the time of writing, the patient was alive with no sign of recurrence and under regular follow-ups at the Outpatient

Successful Radical Pneumonectomy for a Primitive Neuroendodermal Tumor in the Lung: A Case Report and Review of the Literature

“…Peripheral PNETs and Ewing's sarcoma belong to the Ewing family of tumors and are small round-cell malignancies originating from spinal cord cells and accounting for 5% of all small round-cell malignant neoplasms (11). Until now, only few pulmonary PNETs have been reported in the literature (12)(13)(14). Common clinical manifestations include chest pain, cough, and fever.…”

18F-FDG PET/CT Findings in a Patient With Primary Primitive Neuroectodermal Tumor of the Lung

“…Primitive neuroectodermal tumor is a highly malignant neoplasm that usually arises in the bone or soft tissue in children and adolescents with a slight male preponderance. [1][2][3][4] Primary PNET of the lung is very rare with a poor prognosis. [1][2][3][4][5][6] The most common clinical symptoms of pulmonary PNET are cough, hemoptysis, dyspnea, or chest pain.…”

“…[1][2][3][4] Primary PNET of the lung is very rare with a poor prognosis. [1][2][3][4][5][6] The most common clinical symptoms of pulmonary PNET are cough, hemoptysis, dyspnea, or chest pain. [4][5][6][7][8][9] However, none of these clinical manifestations are specific, so as imaging findings.…”

“…After the completion of chemotherapy, a chest CT was performed, which displayed decrease in sizes of the lung tumor and mediastinal lymph nodes. Primitive neuroectodermal tumor is a highly malignant neoplasm that usually arises in the bone or soft tissue in children and adolescents with a slight male preponderance 1–4 . Primary PNET of the lung is very rare with a poor prognosis 1–6 .…”

Triple-phase 99mTc-3P-RGD2 imaging of peripheral primitive neuroectodermal tumor in the hip muscle group with bone metastasis

“…PNETs are most commonly encountered in pediatric patients with diverse clinical manifestations, and are classified into three groups based on the tissue of origin: Central nervous system (CNS) PNETs, neuroblastoma and peripheral PNEs (pPNETs) derived from tissues outside the CNS and autonomic nervous system (1). pPNETs occur predominantly during infancy or childhood, and are located in the abdomen (2,3), thoracopulmonary region (4,5) and, rarely, in the head and neck region (6). pPNETs are extremely rare in adults, particularly in the hip muscles with bone metastasis.…”