Primidone (Mysoline) in the Treatment of Clinical Petit Mal in Children

Briggs, Judy; Tucker, Joyce

doi:10.1016/s0140-6736(54)90759-x

Cited by 13 publications

(3 citation statements)

References 4 publications

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“…Digestive disorders were as rare in our PRM patients (4%) as in other reports (2% by Handley and Stewart, 1952; 2% by Doyle and Livingston, 1953; 1% by Livingston and Petersen, 1956; 5% by Millichap and Aymat, 1968; 3% by Rodin et al, 1976), and occurred with higher PB levels than in children who had no side effects. The 36% incidence de- scribed by Briggs and Tucker (1954) in children receiving PRM alone may due to the abrupt initiation of treatment as described by Timberlake et al (1955) and Painter (1983), but this does not explain the 30% occurrence in adults started with 125 mg PRM daily (Mattson et al, 1985). The AED least tolerated by our patients was phenytoin (PHT), confirming the results of a multicenter study (Beghi et al, 1986).…”

supporting

confidence: 83%

Clinical Side Effects of Phenobarbital, Primidone, Phenytoin, Carbamazepine, and Valproate During Monotherapy in Children

1988

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The rate of onset of side effects was examined in 392 pediatric outpatients who received long-term monotherapy with phenobarbital (PB), primidone (PRM), phenytoin (PHT), carbamazepine (CBZ), or valproate (VPA) for epilepsy or febrile convulsions. The severity of side effects (based on need to alter treatment), the nature of each drug's most common side effects, and the doses and plasma levels of occurrence were recorded. Our results show that usually accepted therapeutic ranges are well tolerated. Indeed, although some form of side effect occurred in 50% of patients, treatment had to be changed in only 18% and the drug had to be stopped in only 7%. In decreasing order, the rates for side effects were PHT (71%) greater than PB (64%) greater than CBZ (43%) greater than VPA (43%) greater than PRM (29%). Serious side effects requiring withdrawal of treatment occurred at the following rates: PHT (10%) greater than VPA (8%) greater than PRM (8%) greater than PB (4%) greater than CBZ (3%). Among our patients, the best tolerated antiepileptic drug (AED) was CBZ, and the least tolerated was PHT. Behavioral disorders were most common with PB, neurologic disorders with PHT, digestive tract disorders with VPA, and gingival hyperplasia and hirsutism with PHT. Behavioral disorders involving excitement seen with PB and PRM occurred most commonly at low plasma levels. Behavioral disorders involving depression seen with PB and VPA, those involving excitement seen with PHT and VPA, and digestive disorders seen with VPA occurred particularly when plasma levels were high.

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supporting

confidence: 83%

Clinical Side Effects of Phenobarbital, Primidone, Phenytoin, Carbamazepine, and Valproate During Monotherapy in Children

1988

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“…Die klinisch bereits in den 50er Jahren häufig beschriebenen Persönlichkeitsveränderungen bzw. expansiven Verhaltensstörungen sind trotz intensiver Recherche kaum empirisch untersucht worden (Smith 1953und 1954, Briggs 1954, Nathan 1954, Livingston 1956.…”

Section: Studien An Epileptischen Patientenunclassified

Antikonvulsiva und ihre psychischen Wirkungen - eine Übersicht

Blank

1990

Fortschr Neurol Psychiatr

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In a review of more than 200 studies over the last three decades, the manifold psychic effects of anticonvulsives on healthy persons, on patients with and without epilepsy, on patients with mental disorders with or without cerebral damages are analysed and summarized. The following results are mainly shown: 1. Carbamazepine: a positive effect on "expansive" behaviour and mood can be observed in about 50-60% of the patients. The cognitive and psychomotor performance is almost unchanged. 2. Valproinate: Negative psychic effects can rarely be seen for a longer time (exception: reversible encephalopathy). The behaviour can similarly be influenced as with carbamazepine. 3. Phenytoin: Cognitive and psychomotor performance is negatively influenced. The effects on behaviour are contradictory. 4. Phenobarbitone and Primidone: Diverse negative effects on performance and behaviour, especially as "expansive" disorders in children and adolescents, seemed to be proven. 5. Ethosuximide: Beside the drug specific provocation of psychotic disorders, both, positive and negative effects on behaviour and cognitive functions are discussed. 6. The psychic effects of other anticonvulsives such as Benzodiazepines, Sulthiame and Pheneturide are shortly summarized. 7. Polytherapy: Negative influences on psychic functions are significant. Finally the results are discussed concerning their clinical relevance.

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“…(mysoline), which is very widely used, also has a low toxicity. Briggs and Tucker (8) observed one instance of leucocytopenia as a late sequela in the treatment of 22 children suffering from petit mal. Livingston and Petersen (37) observed numerous side-effects but no haematological complications in 486 patients.…”

Section: Panmyelopathy Panmyelophthisis Aplastic Anaemiamentioning

confidence: 99%

Haematological Aspects during Treatment with Anticonvulsant Drugs

Vries

1965

Epilepsia

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SUMMARY The literature comprises many reports on haematological complications during anticonvulsant medication. Systematic haematological surveillance of epileptic patients is considered necessary to prevent these complications. This paper discusses ways and means to ensure maximum efficacy of this surveillance in clinics without a specialized haematological laboratory. A description is also given of methods suitable for supplementing and extending the routine examinations. RÉSUMÉ La littérature comporte de nombreuses observations de complications hématologiques au cours des traitements anticonvulsivants. La surveillance hématologique des épileptiques est done nécessaire pour prévenir ces complications. Ce travail discute les moyens qui assurent une efficacité maximum à pareille surveillance dans les cliniques qui ne comportent pas un laboratoire spécialisé en hématologic Il fournit également une description des méthodes convenables pour compléter et élargir les examens de routine.

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Primidone (Mysoline) in the Treatment of Clinical Petit Mal in Children

Cited by 13 publications

References 4 publications

Clinical Side Effects of Phenobarbital, Primidone, Phenytoin, Carbamazepine, and Valproate During Monotherapy in Children

Clinical Side Effects of Phenobarbital, Primidone, Phenytoin, Carbamazepine, and Valproate During Monotherapy in Children

Antikonvulsiva und ihre psychischen Wirkungen - eine Übersicht

Haematological Aspects during Treatment with Anticonvulsant Drugs

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