Primates as a model for research

Garbarini, Nicole

doi:10.1242/dmm.004861

Cited by 12 publications

(8 citation statements)

References 8 publications

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“…As a result, remarkable anatomical and physiological similarities between humans and rhesus monkeys are present. These similarities have prompted researchers to investigate a wide range of biomechanical and physiological mechanisms, and to assess novel therapies in the rhesus monkey, before applying their discoveries to humans [ 1 , 3 , 9 ]. However, not only human clinicians, but also primate veterinarians will benefit from a detailed description of the anatomy of the rhesus monkey.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The rhesus monkey ( Macaca mulatta ) is one of the most studied non-human primates [ 1 ]. This animal originates in the southern parts of Asia, but currently it can be found in research facilities worldwide [ 1 , 2 ]. Rhesus monkeys are commonly used in toxicity studies and their pivotal role in unraveling the mechanisms of various diseases should not be underestimated [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Topographical Anatomy of the Rhesus Monkey (Macaca mulatta)—Part I: Thoracic Limb

Casteleyn

Gram

Bakker

2023

Veterinary Sciences

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Since the rhesus monkey (Macaca mulatta) is genetically closely related to man, it is generally accepted that its anatomy and physiology are largely similar to that of humans. Consequently, this non-human primate is most commonly used as a model in biomedical research. Not only the validation of the obtained research data, but also the welfare of the captive rhesus monkeys are subject to thorough anatomical knowledge of this species. Unfortunately, anatomical literature on the rhesus monkey is scarce, outdated, and hardly available at present. Furthermore, its anatomy is only illustrated by means of line drawings or black-and-white photographs. Thus, the aim of this study was to describe the anatomy of the thoracic limb of the rhesus monkey topographically, studying the various anatomical structures in relation to each other. In this manuscript, the anatomy of the thoracic limb is described per region. The structures that are visible on the different layers, from the superficial to the deepest layer, are described both in text and in numerous color images. As expected, the anatomy of the rhesus monkey is almost identical to human anatomy. However, some striking differences have been identified. This supports the necessity for an extensive publication on the anatomy of the rhesus monkey

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Topographical Anatomy of the Rhesus Monkey (Macaca mulatta)—Part I: Thoracic Limb

Casteleyn

Gram

Bakker

2023

Veterinary Sciences

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“…Wild populations of rhesus monkeys ( Macaca mulatta ) live in the southeastern parts of Asia, but this species can also be found in research facilities worldwide, as it is one of the most studied nonhuman primates [ 1 , 2 ]. They serve as animal models in toxicity studies, aid in unraveling the pathogenesis of various diseases and are key in the development of many vaccines against, e.g., Malaria, West Nile virus and H5N1 Influenza [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Topographical Anatomy of the Rhesus Monkey (Macaca mulatta)—Part II: Pelvic Limb

Casteleyn

Robin

Bakker

2023

Veterinary Sciences

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The rhesus monkey (Macaca mulatta) is a widely used model in biomedical research because its anatomy and physiology bear many similarities to those of humans. Extensive knowledge of the anatomy of this nonhuman primate species is not only required for the correct interpretation of obtained research data but also valuable for the welfare of captive individuals housed in, e.g., zoos. As anatomical publications on the rhesus monkey are hardly available, outdated and provide only line drawings or black-and-white photographs, the anatomy of the rhesus monkey was readdressed in this study. The various anatomical structures are described in relation to each other topographically per hindlimb region. The hip region, the upper limb, the knee, the lower limb and the foot are described from various perspectives. The structures that are visible in the different layers, from the superficial to the deepest layer, were photographed. Although the anatomy of the hindlimbs of rhesus monkeys and humans are remarkably similar, various subtle dissimilarities have been observed. Consequently, an open-access publication that focuses on the anatomy of the rhesus monkey would be highly valued by both biomedical researchers and veterinarians.

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“…Whereas the rodent model has scientific advantages based on the availability of transgenic and optogenetic toolkits, many neuroscientists recognize its limitations as a clinical model (STAIR, 1999;Kwon et al, 2010Kwon et al, , 2013. Non-human primates (NHP) have long been considered the gold standard for clinical neuroscience research; however, the significant ethical and financial barriers associated with NHP research are prohibitive to many investigators (Garbarini, 2010;Prescott, 2010). Thus, the laboratory pig has emerged as a practical alternative model for many neuroscientists.…”

Section: Introductionmentioning

confidence: 99%

In vivo Population Averaged Stereotaxic T2w MRI Brain Template for the Adult Yucatan Micropig

et al. 2020

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Primates as a model for research

Abstract: Despite the political, ethical and financial complexities, there are some human diseases that researchers feel can only be understood by working with non-human primates. Nicole Garbarini investigates.

Cited by 12 publications

References 8 publications

Topographical Anatomy of the Rhesus Monkey (Macaca mulatta)—Part I: Thoracic Limb

Topographical Anatomy of the Rhesus Monkey (Macaca mulatta)—Part I: Thoracic Limb

Topographical Anatomy of the Rhesus Monkey (Macaca mulatta)—Part II: Pelvic Limb

In vivo Population Averaged Stereotaxic T2w MRI Brain Template for the Adult Yucatan Micropig

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