2018
DOI: 10.1113/jp275422
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Primate fetal hepatic responses to maternal obesity: epigenetic signalling pathways and lipid accumulation

Abstract: Maternal obesity (MO) increases offspring cardiometabolic disease risk. Altered fetal liver development in response to the challenge of MO has metabolic consequences underlying adverse offspring life-course health outcomes. Little is known about the molecular pathways and potential epigenetic changes regulating primate fetal liver responses to MO. We hypothesized that MO would induce fetal baboon liver epigenetic changes resulting in dysregulation of key metabolic pathways that impact lipid metabolism. MO was … Show more

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Cited by 57 publications
(48 citation statements)
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“…According to one study in non‐human primate programmed by MO, fetal liver pathways altered in response to MO were TCA cycle, proteasome, oxidative phosphorylation, glycolysis signalling pathways together with lipid accumulation; they suggest that as fetuses F1 are on an early trajectory of NAFLD and NASH (Puppala et al . ). Those pathways are also dysregulated in rat liver MO‐F1 in our study.…”
Section: Discussionmentioning
confidence: 97%
“…According to one study in non‐human primate programmed by MO, fetal liver pathways altered in response to MO were TCA cycle, proteasome, oxidative phosphorylation, glycolysis signalling pathways together with lipid accumulation; they suggest that as fetuses F1 are on an early trajectory of NAFLD and NASH (Puppala et al . ). Those pathways are also dysregulated in rat liver MO‐F1 in our study.…”
Section: Discussionmentioning
confidence: 97%
“…In this context, a recent article published in The Journal of Physiology by Puppala et al . () has advanced this research line with non‐human primates, in this case baboons ( Papio hamadryas ). In their study, the authors examined the molecular mechanisms (genetic and epigenetic changes) by which maternal obesity impacts the developing baboon fetal liver resulting in dysregulation of key metabolic pathways that impact lipid metabolism.…”
Section: Introductionmentioning
confidence: 99%
“…The aim of Puppala et al . was to examine the molecular mechanisms by which a high‐fat maternal diet affects the developing fetal liver. To that end, a group of 32 healthy female baboons of similar age, body dimensions and weight were fed with diets differentiated for the supply of fats and sugars for at least 9 months before pregnancy.…”
Section: Introductionmentioning
confidence: 99%
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