2018
DOI: 10.1113/jp276769
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A mother's gift: consequences of unhealthy diet for offspring metabolism

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“…In recent years, it has become increasingly clear that susceptibility to obesity and type 2 diabetes is strongly influenced by exposure to an adverse intrauterine environment during early development 2 3. In addition, human epidemiological studies,4 5 as well as rodent studies,6–9 have shown that both maternal4–7 10 11 and paternal8 9 12–14 environmental exposures are critical factors influencing the development of obesity and type 2 diabetes in offspring. This can lead to a vicious cycle of metabolic dysfunction, where rising rates of obesity, pre-diabetes, and diabetes in individuals of reproductive age are propagated through subsequent generations.…”
Section: Introductionmentioning
confidence: 99%
“…In recent years, it has become increasingly clear that susceptibility to obesity and type 2 diabetes is strongly influenced by exposure to an adverse intrauterine environment during early development 2 3. In addition, human epidemiological studies,4 5 as well as rodent studies,6–9 have shown that both maternal4–7 10 11 and paternal8 9 12–14 environmental exposures are critical factors influencing the development of obesity and type 2 diabetes in offspring. This can lead to a vicious cycle of metabolic dysfunction, where rising rates of obesity, pre-diabetes, and diabetes in individuals of reproductive age are propagated through subsequent generations.…”
Section: Introductionmentioning
confidence: 99%