Primary vitreoretinal natural killer/T-cell lymphoma with breast involvement: A case report and review of the literature

Gao, Shuang; Zhou, Yingming; Jin, Xiaolong; Lin, Zhongjing; Zhong, Yisheng; Shen, Xi

doi:10.1016/j.survophthal.2018.10.003

Cited by 10 publications

(4 citation statements)

References 44 publications

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“…3 Recently, Gao et al reported a case of primary vitreoretinal natural killer/T-cell lymphoma with concomitant breast involvement. 30 Lung involvement by NK/T-cell lymphoma, primary or secondary, is seldom reported and occurs most commonly as part of widely disseminated disease, and carries a poor prognosis for the patient. Morovic et al reported a case of nasal NK/ T-cell lymphoma with secondary lung involvement, despite aggressive chemotherapy and intensive supportive treatment, the patient died shortly after the initiation of therapy.…”

Section: Discussionmentioning

confidence: 99%

Bilateral intraocular and lung involvements associated with Nasal NK/T-cell lymphoma

Wang

Jia

Zhang

et al. 2022

European Journal of Ophthalmology

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Background To report a rare case of nasal natural killer/T (NK/T) cell lymphoma with bilateral intraocular and lung metastasis and to further describe the clinical features of intraocular manifestations. Case presentation A 54-year-old man presented with a 3-month history of left nasal congestion, and bilateral vision impairment of one week duration. Subsequent maxillary computed tomography (CT) and multiple biopsies confirmed the diagnosis of nasal NK/T-cell lymphoma. EBV-encoded small RNA (EBER) in situ hybridization revealed EBV infection. A comprehensive ophthalmic examination found lymphoma-associated retinopathy and choroidopathy, which presented as bilateral diverse patterns and retinal detachment. In addition, the chest CT showed multiple scattered nodules in both lungs, and soft-tissue mass in the left hilum with mediastinal and axillary lymphadenopathy. The condition of this patient deteriorated rapidly and he died shortly after diagnosis. Conclusions The rarity of secondary ocular NK/T-cell lymphoma makes it challenging to identify these tumors early. Both otolaryngologist and ophthalmologists should be aware of ocular involvement and other secondary manifestations of NK/T-cell lymphoma.

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Section: Discussionmentioning

confidence: 99%

Bilateral intraocular and lung involvements associated with Nasal NK/T-cell lymphoma

Wang

Jia

Zhang

et al. 2022

European Journal of Ophthalmology

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“…4 On the other hand, extra-CNS/testicular involvement after PVRL is rare. Although some cases have been reported, [5][6][7][8][9][10][11] there are no cross-sectional or cohort studies. Among 105 patients diagnosed with VRL in our department, some of the patients diagnosed with PVRL subsequently developed lymphomas in organs other than the CNS and testis.…”

Section: Clinical Features Of Primary Vitreoretinal Lymphoma Developi...mentioning

confidence: 99%

Clinical features of primary vitreoretinal lymphoma developing extra‐central nervous system (CNS)/testicular lymphomas with or without CNS involvement: A single‐centre study of 13 cases

et al. 2023

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“…Biopsy-proven primary vitreoretinal natural killer/T cell lymphoma with breast involvement resolved with chemotherapy, intravitreal MTX, and ocular radiotherapy. 35 Two patients with ocular involvement following systemic natural killer/T cell lymphoma achieved complete remission after single injection of intravitreal MTX. 36 Another patient who presented with intraocular T cell lymphoma as a manifestation of mycosis fungoides was also successfully treated with intravitreal MTX.…”

Section: Immunosuppressantsmentioning

confidence: 99%

A comprehensive review of intravitreal immunosuppressants and biologicals used in ophthalmology

et al. 2022

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Systemic immunosuppressants and biologicals have been a valuable tool in the treatment of inflammatory diseases and malignancies. The safety profile of these drugs has been debatable, especially in localized systems, such as the eye. This has led to the search for fairly local approaches, such as intravitreal, subconjunctival, and topical route of administration. Immunosuppressants have been used as a second-line drug in patients intolerable to corticosteroids or those who develop multiple recurrences on weaning corticosteroids. Similarly, biologicals have also been used as the next line of therapy, when adequate control of inflammation could not be attained or immunosuppressants were contraindicated to patients. Intravitreal immunosuppressants, such as methotrexate and sirolimus, have been extensively studied in noninfectious posterior uveitis, whereas limited studies have established the efficacy of intravitreal biologicals, such as infliximab and adalimumab. Most of these drugs have shown good safety profile and tolerability in animal studies alone and have not been studied further in human subjects. However, most of the studies in literature are single-case reports or case series which limits the level of evidence. In this comprehensive review, we discuss the mechanism of action, pharmacodynamics, pharmacokinetics, indications, efficacy, and side effects of different intravitreal immunosuppressants and biologicals that have been studied in literature.

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Primary vitreoretinal natural killer/T-cell lymphoma with breast involvement: A case report and review of the literature

Cited by 10 publications

References 44 publications

Bilateral intraocular and lung involvements associated with Nasal NK/T-cell lymphoma

Bilateral intraocular and lung involvements associated with Nasal NK/T-cell lymphoma

Clinical features of primary vitreoretinal lymphoma developing extra‐central nervous system (CNS)/testicular lymphomas with or without CNS involvement: A single‐centre study of 13 cases

A comprehensive review of intravitreal immunosuppressants and biologicals used in ophthalmology

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