Clinical features of primary vitreoretinal lymphoma developing <scp>extra‐central nervous system (CNS)</scp>/testicular lymphomas with or without <scp>CNS</scp> involvement: A single‐centre study of 13 cases

Kunimi, Keiko; Usui, Yoshihiko; Sugawara, Risa; Asakage, Masaki; Tsubota, Kinya; Gotoh, Akihiko; Gotô, Hiroshi

doi:10.1111/bjh.18663

Br J Haematol

2023

DOI: 10.1111/bjh.18663

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Clinical features of primary vitreoretinal lymphoma developing extra‐central nervous system (CNS)/testicular lymphomas with or without CNS involvement: A single‐centre study of 13 cases

Keiko Kunimi

Yoshihiko Usui

Risa Sugawara

et al.

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“… 2 The frequency of involvement of primary organs other than CNS, known as secondary (metastatic) cases, is approximately 12.4%. 7 Therefore, early diagnosis of VRL is of great importance for deciding appropriate work-up and treatment strategies and improving prognosis.…”

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confidence: 99%

Vitreous Humor Proteomic Profile in Patients With Vitreoretinal Lymphoma

Komatsu,

Usui,

Tsubota

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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Purpose Vitreoretinal lymphoma is a high-grade malignant non-Hodgkin lymphoma with poor prognosis. The objective of this study was to elucidate the proteome profile of the vitreous in patients with vitreoretinal lymphoma (VRL), aiming to advance understanding of the pathophysiology of VRL. Methods Comprehensive proteomic analyses of vitreous humor using liquid chromatography with tandem mass spectrometry were performed for 10 patients with VRL, 10 control patients with idiopathic epiretinal membrane or macular hole, and 10 patients with ocular sarcoidosis. Differentially expressed proteins (DEPs) were identified by comparing VRL with controls and sarcoidosis, and functional pathway analysis was performed. Finally, vitreous concentrations of representative DEPs that were significantly upregulated in proteomics study were measured by ELISA using a separate cohort. Results In total, 1594 proteins were identified in the vitreous humor of VRL, control, and sarcoidosis samples. Also, 282 DEPs were detected in VRL, 249 upregulated and 33 downregulated, compared with controls. Enrichment pathway analysis showed alterations in proteasome-related pathways. Compared to controls and sarcoidosis, 14 DEPs in VRL showed significant upregulation. In the validation study, ELISA confirmed significantly higher vitreous concentrations of PSAT1, YWHAG, and 20S/26S proteasome complex in VRL compared with controls and sarcoidosis. Among the upregulated DEPs, vitreous PITHD1 and NCSTN concentrations correlated positively with vitreous IL-10 concentrations. Conclusions This study highlights aberrations in protein expression pattern in the vitreous of patients with VRL. The DEPs identified in this study may play pivotal roles in VRL pathogenesis, providing insights to enhance understanding of VRL pathophysiology and contribute to the development of VRL biomarkers.

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mentioning

confidence: 99%

Vitreous Humor Proteomic Profile in Patients With Vitreoretinal Lymphoma

Komatsu,

Usui,

Tsubota

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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Clinical features of primary vitreoretinal lymphoma developing extra‐central nervous system (CNS)/testicular lymphomas with or without CNS involvement: A single‐centre study of 13 cases

Cited by 1 publication

References 20 publications

Vitreous Humor Proteomic Profile in Patients With Vitreoretinal Lymphoma

Vitreous Humor Proteomic Profile in Patients With Vitreoretinal Lymphoma

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