Primary Undifferentiated Penile Sarcoma in Adolescence

Abstract

We report a case of primary penile undifferentiated sarcoma. A 16-year-old adolescent man visited Pusan National University Hospital complaining of a painless mass on his penis that was increasing in size. Magnetic resonance images revealed a 5×5-cm mass and pathological examinations revealed small round cell sarcomas with neuroendocrine differentiation. The tumor, which had metastatic pulmonary nodules, was treated by tumorectomy and systemic chemotherapy. Thirty-four months after the initial diagnosis, the patient was still alive without evidence of local recurrence or metastatic disease. This is our second case of an undifferentiated penile sarcoma.

Primary Radiation-Induced Sarcoma of the Penis: Case Report and Review of the Literature

“…Deep lesions show a greater propensity to metastasize and have a poorer prognosis. The other important factor related with poor prognosis is tumor size, degree of differentiation, and metastatic invasion [8,9].…”

A report of two deep-seated noncutaneous penile tumors: more than meets the eye

“…Sarcomas of the penis are described as superficial or deep, as discussed earlier, which carry differing risks of distant metastatic disease and prognosis. Tumor size, mitotic activity, and depth are the most useful predictors of patient outcomes [7] , [8] , [9] . Superficial leiomyosarcoma arises from the dartos muscle, erector pilorum muscle, or wall of a superficial blood vessel and often presents as small painless nodules without deep invasion or urinary symptoms [5] .…”

“…Treatment in these cases typically consists of wide local tumor excision vs partial penectomy. Distant metastatic disease is rare with a good prognosis for recurrence-free survival [7] , [8] . Conversely, deep-seated tumors arise from the smooth muscles of the vessels comprising the corpora and tend to be more aggressive with rapid growth, urinary symptomatology, and poorer prognosis.…”

“…Lymph node dissection is not routinely performed given low risk of lymphatic spread and limited survival benefit following lymphadenectomy. This is different from squamous cell carcinoma, where lymphadenectomy is typically performed [5] , [7] .…”

Pleomorphic malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma of the glans penis

“…It occurs more commonly in the extremities, and cases of primary undifferentiated pleomorphic sarcoma of the penis are very difficult to find. 9 El Hayek and colleagues 10 suggest that one possible explanation could be the occurrence of de-differentiation. On the other hand, the tumour could have been pleomorphic from the start.…”