Primary tuberculosis of the retina.

Saini, Janmeet S.; Mukherjee, Arindam; Nadkarni, Nisha

doi:10.1136/bjo.70.7.533

Cited by 23 publications

(8 citation statements)

References 4 publications

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“…Optical coherence tomography imaging in that case revealed a round intraretinal hyperreflective lesion surrounding a hyporeflective core, which the authors postulated represented abscess surrounded by inflammatory response. 4 This is in contrast to our case that showed homogenous hyperreflectivity on cross-sectional OCT, without the hyporeflective core as described by Pirraglia et al Saini et al 5 also described a case of primary retinal tuberculosis in a child who presented with a yellowish mass involving the entire retina. The eye was enucleated, and histopathologic examination demonstrated epithelioid histiocytes and lymphocytes around a caseous necrotic center within the retina, without evidence of choroidal involvement, confirming the diagnosis of primary retinal tuberculosis.…”

Section: Discussioncontrasting

confidence: 90%

Presumed Intraretinal Tuberculosis: Case Report With Multimodal Imaging Including Optical Coherence Tomography Angiography

Alsberge

Safi²,

Peng³

et al. 2023

RETINAL Cases &Amp; Brief Reports

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Purpose: To report a case of presumed intraretinal tuberculosis evaluated with optical coherence tomography angiography.Methods: Case report.Results: A 61-year-old woman recently immigrated from China presented with round yellow-white retinal lesions in the left eye. The lesions were evaluated with multimodal imaging, including optical coherence tomography angiography. Subsequent serologic testing revealed a positive QuantiFERON-TB Gold test, whereas workup for other entities was negative. The patient was diagnosed with presumed intraretinal tuberculosis. She was started on systemic antitubercular therapy and the lesions regressed. The regression was documented with optical coherence tomography angiography.Conclusion: Case reports of primary intraretinal tuberculosis are uncommon. To the best of our knowledge, this is the first case to demonstrate optical coherence tomography angiography findings of presumed intraretinal tuberculosis.

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Section: Discussioncontrasting

confidence: 90%

Presumed Intraretinal Tuberculosis: Case Report With Multimodal Imaging Including Optical Coherence Tomography Angiography

Alsberge

Safi²,

Peng³

et al. 2023

RETINAL Cases &Amp; Brief Reports

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“…The presence of Mycobacterium tuberculosis in the retina can activate retinal microglia and blood-derived macrophages, inducing intraretinal granuloma [11]. Saini et al described a microscopic examination of tubercular granulomas in the retina, where the tubercles consisted of a central caseous necrosis surrounded by epithelioid cells, lymphocytes, and giant cells [12].…”

Section: Discussionmentioning

confidence: 99%

Spectral domain optical coherence tomography imaging of tubercular chorioretinitis and intraretinal granuloma. Intraretinal tuberculosis: a case report

et al. 2015

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The aim of this study is to report the clinical and spectral domain optical coherence tomography (SD-OCT) findings in a patient suffering from ulcerative colitis with bilateral tubercular chorioretinitis and intraretinal granuloma regressed with systemic antitubercular therapy (ATT). This study is a case report of a 33-year-old Bangladeshi male with ulcerative colitis treated with oral corticosteroids and azathioprine who was referred to our department with a diagnosis of central serous chorioretinopathy. Serological tests, the Mantoux skin test, complete ophthalmologic examination, ocular fundus photography, fundus fluorescein angiography, and SD-OCT scans were performed. The ophthalmological inflammatory pattern and serological investigations provided an early diagnosis of ocular tuberculosis. Systemic ATT led to significant improvement and resolution of the ocular inflammation. SD-OCT was a useful non-contact imaging technique in the follow-up of tubercular choroiditis. The excellent response to systemic ATT confirmed the clinical diagnosis. This is an unusual case of tubercular chorioretinitis with intraretinal granuloma and is the first such SD-OCT description reported in the ophthalmological literature.

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“…Overlying choriocapillaris and RPE including the outer retina can be involved in the inflammatory process. These lesions reveal granulomas with central caseous necrosis and involve the inner and mid choroid with presence of a lymphocytic infiltration in the outer choroid [9,[35][36][37][38]. The vitreous can display the presence of epithelioid histiocytes, lymphocytes and occasional giant cells.…”

Section: Histopathological Data On Human Ocular Tbmentioning

confidence: 99%

Pathogenesis of ocular tuberculosis: New observations and future directions

2020

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Ocular tuberculosis (OTB) encompasses all forms of intra-and extra-ocular inflammation associated with Mycobacterium tuberculosis (Mtb) infection. However, the organism is rarely found in ocular fluid samples of diseased eyes, rendering the pathomechanisms of the disease unclear. This confounds clinical decision-making in diagnosis and treatment of OTB.Here, we critically review existing human and animal data related to ocular inflammation and TB pathogenesis to unravel likely pathomechanisms of OTB. Broadly there appear to be two fundamental mechanisms that may underlie the development of TB-associated ocular inflammation: a. inflammatory response to live/ replicating Mtb in the eye, and b. immune mediated ocular inflammation induced by non-viable Mtb or its components in the eye. This distinction is significant as in direct Mtb-driven mechanisms, diagnosis and treatment would be aimed at detection of Mtb-infection and its elimination; while indirect mechanisms would primarily require anti-inflammatory therapy with adjunctive anti-TB therapy. Further, we discuss how that most clinical phenotypes of OTB likely represent a combination of both mechanisms, with one being predominant than the other.

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Primary tuberculosis of the retina.

Cited by 23 publications

References 4 publications

Presumed Intraretinal Tuberculosis: Case Report With Multimodal Imaging Including Optical Coherence Tomography Angiography

Presumed Intraretinal Tuberculosis: Case Report With Multimodal Imaging Including Optical Coherence Tomography Angiography

Spectral domain optical coherence tomography imaging of tubercular chorioretinitis and intraretinal granuloma. Intraretinal tuberculosis: a case report

Pathogenesis of ocular tuberculosis: New observations and future directions

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