Primary Trauma Care

Wilkinson, D.; McDougall, Robert J

doi:10.1111/j.1365-2044.2007.05301.x

Cited by 27 publications

(31 citation statements)

References 5 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The acute management of these patients is a major challenge and determines the long-term clinical outcome. The first hour after their occurrence is the most critical, defined as the "golden hour" (Wilkinson and McDougall, 2007). The challenge is to stabilize and oxygenate the patient and to transfer the patient to the hospital as quickly as possible.…”

Section: Discussionmentioning

confidence: 99%

Paracetamol-Induced Hypothermia Is Independent of Cannabinoids and Transient Receptor Potential Vanilloid-1 and Is Not Mediated by AM404

Ayoub

Pryce²,

Seed³

et al. 2011

Drug Metab Dispos

View full text Add to dashboard Cite

ABSTRACT:In recent years, there has been increasing interest in hypothermia induced by paracetamol for therapeutic purposes, which, in some instances, has been reported as a side effect. Understanding the mechanism by which paracetamol induces hypothermia is therefore an important question. In this study, we investigated whether the novel metabolite of paracetamol, N-(4-hydroxyphenyl)arachidonylamide (AM404), which activates the cannabinoid (CB) and transient receptor potential vanilloid-1 (TRPV1) systems, mediates the paracetamolinduced hypothermia. The hypothermic response to 300 mg/kg paracetamol in CB 1 receptor (CB 1 R) and TRPV1 knockout mice was compared to wild-type mice. Hypothermia induced by paracetamol was also investigated in animals pretreated with the CB 1 R or TRPV1 antagonist 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperdinyl-1H-pyrazole-3-carboxamide trifluoroacetate salt (AM251) or 4-chloro-3-methoxycinnamanilide (SB366791), respectively. In CB 1 R or TRPV1 knockout mice, paracetamol induced hypothermia to the same extent as in wild-type mice. In addition, in C57BL/6 mice pretreated with AM251 or SB366791, paracetamol induced hypothermia to the same extent as in control mice. AM404 failed to induce hypothermia at pharmacological doses. Inhibition of fatty acid amide hydrolase (FAAH), which is involved in the metabolism of paracetamol to AM404, did not prevent the development of hypothermia with paracetamol. Paracetamol also induced hypothermia in FAAH knockout mice to the same extent as wild-type mice. We conclude that paracetamol induces hypothermia independent of cannabinoids and TRPV1 and that AM404 does not mediate this response. In addition, potential therapeutic value of combinational drug-induced hypothermia is supported by experimental evidence.

show abstract

Section: Discussionmentioning

confidence: 99%

Paracetamol-Induced Hypothermia Is Independent of Cannabinoids and Transient Receptor Potential Vanilloid-1 and Is Not Mediated by AM404

Ayoub

Pryce²,

Seed³

et al. 2011

Drug Metab Dispos

View full text Add to dashboard Cite

show abstract

“…The reasons for this difference includes lack of resources, cost, trained human resource and trauma management education. 6 …”

Section: Introductionmentioning

confidence: 99%

“…Following the initial course, a PTC Board of Governors was established and large number of courses has been run at every corner of the country. 6 …”

Section: Introductionmentioning

confidence: 99%

“…6 , 10 Out of them only one study from Iran evaluates the effectiveness of workshop and that too uses only MCQs for evaluation. 10 To the best of our knowledge this is one of the first study which audits the effectiveness of the PTC workshop participants knowledge as well as skills of trauma management after two days of the provider workshop.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effectiveness of the Primary Trauma Care Course: Is the outcome satisfactory?

Jawaid¹,

A²,

Masood³

et al. 2013

Pak J Med Sci

View full text Add to dashboard Cite

Objective: To assess the improvement of knowledge and skills of trauma management among participant of Primary Trauma Care (PTC) workshop. Methods: A two days Primary Trauma Care (PTC) provider workshop was organized at Dow International Medical College, Karachi - Pakistan on March 5th and 6th 2011. Participant’s knowledge was assessed by 30 Best Choice Questions (BCQs) and their trauma management skills were assessed by management of trauma case scenario both at pre and post workshop. All scenarios performed by participants were video recorded and marked on a 20 points check list and evaluated by two PTC trainers and graded after consensus. Percentage of participants who scored more than 70% marks on knowledge and skills component were also analyzed. Data was analyzed by SPSS version 17. Wilcoxon Sign Rank test was used to find out significant difference between pre and post workshop score. Results: A total of 20 participants attended the full workshop. Median One best question score before the workshop was 19.5 and post workshop was 25 (p<0.0001). Trauma skills scenario score also showed marked improvement with median score of 3.5 pre workshop and 9.5 post workshop (p<0.0001). Total 19 participants had ≥70% post workshop knowledge score. However, only 4 participants had trauma skill score with ≥70 marks. Conclusion: Primary Trauma Care workshop could be an effective course for gaining of knowledge and skills of initial management of trauma patients. However, some modifications need to be done for training of skills components to maximize the output of this interactive workshop.

show abstract

“…We have been doing the primary trauma care training in association with Primary Trauma Care Foundation, the UK [3]. Over 1,000 medical and paramedical personnel have been trained over the past 7 years.…”

mentioning

confidence: 99%

Training in Trauma Care

Prasad¹

2012

Indian J Surg

View full text Add to dashboard Cite

Primary Trauma Care

Cited by 27 publications

References 5 publications

Paracetamol-Induced Hypothermia Is Independent of Cannabinoids and Transient Receptor Potential Vanilloid-1 and Is Not Mediated by AM404

Paracetamol-Induced Hypothermia Is Independent of Cannabinoids and Transient Receptor Potential Vanilloid-1 and Is Not Mediated by AM404

Effectiveness of the Primary Trauma Care Course: Is the outcome satisfactory?

Training in Trauma Care

Contact Info

Product

Resources

About