Primary syphilitic chancre in the rectum

Bensusán, Israel Grilo; Gómez-Regife, Leonor

doi:10.1055/s-0034-1377638

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…Chancre of the rectum is usually asymptomatic, but in some people it might cause mild rectal pain or discomfort, constipation, rectal bleeding, and occasionally rectal secretions. The primary chancre usually heals spontaneously within 3-10 weeks, leaving a slightly indurated scar 2. Documented evidence of primary rectal syphilis is limited to case reports 34.…”

Section: Answermentioning

confidence: 99%

An irregular ulcer in the rectum

Wang

Zheng

et al. 2021

BMJ

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Section: Answermentioning

confidence: 99%

An irregular ulcer in the rectum

Wang

Zheng

et al. 2021

BMJ

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Syphilis in Hematopathology Practice: A Diagnostic Challenge

Gutierrez-Lanz

Smith

Perry

2023

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Syphilis, a reemerging disease caused by spirochete Treponema pallidum, is becoming more frequent in surgical pathology and hematopathology practices. Hematopathologists typically receive lymph node biopsies from patients with syphilis who have localized or diffuse lymphadenopathy. Occasionally, syphilis infection in the aerodigestive tract can show a prominent lymphoplasmacytic infiltrate and mimic lymphoma. Besides the varying and occasional atypical morphology, the fact that clinical suspicion tends to be low or absent when histologic evaluation is requested adds to the importance of making this diagnosis. Objective.— To summarize histologic features of syphilitic lymphadenitis and syphilis lesions in the aerodigestive tract, and to review differential diagnosis and potential diagnostic pitfalls. Data Sources.— Literature review via PubMed search. Conclusions.— Characteristic histologic findings in syphilitic lymphadenitis include thickened capsule with plasma cell–rich inflammatory infiltrate, reactive follicular and paracortical hyperplasia with prominent lymphoplasmacytic infiltrate, and vasculitis. Lymph nodes, however, can show a number of other nonspecific histologic features, which frequently makes the diagnosis quite challenging. In the aerodigestive tract, syphilis is characterized by plasma cell–rich infiltrates. Immunohistochemistry for T pallidum is the preferred method for detecting spirochetes; however, this immunohistochemical stain shows cross-reactivity with other treponemal and commensal spirochetes. Differential diagnosis of syphilis in lymph nodes and the aerodigestive tract is broad and includes reactive, infectious, and neoplastic entities. Pathologists should be aware of the histologic features of syphilis and keep this challenging entity in the differential diagnosis.

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Primary syphilitic chancre in the rectum

Cited by 2 publications

References 5 publications

An irregular ulcer in the rectum

An irregular ulcer in the rectum

Syphilis in Hematopathology Practice: A Diagnostic Challenge

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