Primary Synovial Sarcoma of Thyroid Gland: A Case Report

Abstract

Aim and objective We report a case of synovial sarcoma of the thyroid gland and review the literature of few such reported cases. Background Synovial sarcoma of the thyroid gland is exceedingly rare with aggressive features and very poor prognosis. Case description We report a case of 65-year-old man from Iraq who presented initially with a neck mass and was operated at the local hospital for total thyroidectomy, and a separate neck mass extending from the thyroid gland to the upper mediastinum was found. A re-excision of the mass was done with HPE showing malignant peripheral nerve sheath tumor. He was referred to our institute with relapse of the neck mass with compressive symptoms. The mass was excised with the HPE and IHC staining showing grade 2 biphasic synovial sarcoma. Within twenty days of surgery, he presented with severe respiratory distress and tumor with intraluminal tracheal growth. He died of compressive symptoms two weeks after the relapse. Conclusion The early diagnosis and margin-free resection give the best chance of survival for the patient. How to cite this article Lal RK, Hazarika B, Julaha M. Primary Synovial Sarcoma of Thyroid Gland: A Case Report. Int J Otorhinolaryngol Clin 2020;12(2):27–30.

Diagnostic difficulties in evaluation of primary malignant lesions of thyroid: A study of cytomorphology, histopathology, and immunohistochemistry

“…Pre-operative diagnosis based on FNAC is usually not supportive, although HPE may be contributory to some extent. [ 7 ] The conclusive diagnosis of this entity relies mainly on the diagnostic molecular studies such as fluorescence in situ hybridization. [ 5 ] However, immunohistochemistry may show positivity for EMA, CKs, and focal S100 expression (40% cases).…”