Primary surgery versus primary radiotherapy with or without chemotherapy for early adenocarcinoma of the uterine cervix

Lack of any Impact of Histopathology Type on Prognosis in Patients with Early-Stage Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix

“…In the Cochrane review, in patients with stage I or IIA cervical AC and positive pelvic lymph node, Baalbergen et al reported that five-year survival was 91% for patients treated by surgery alone but in spite of adjuvant RT, in the other group was only 34% (Baalbergen et al, 2013). The majority of patients included in our study were treated by radiation therapy or concurrent chemoradiotheraphy postoperatively.…”

Prognostic factors affecting cervical adenocarcinoma: 10 years experience in a single institution

“…There is a trend toward to prefer surgery for early cervical AC. In an analysis [28,29] [28], better outcomes were reported with surgery. However, there were two major criticisms to this study.…”

Radiation resistance: Cancer stem cells (CSCs) and their enigmatic pro-survival signaling

“…It was recently estimated that one-half to two-thirds of cancer patients receive radiation therapy in curative or palliative settings during their disease [1,2]. Radiotherapy is a therapeutic approach with a very high potential for local control: ionizing radiation is equally as effective as surgery in curing prostate [3,4], laryngeal [5], cervical [6], and anal cancers [7]. However, and despite very effective radiation-induced cancer cell elimination and local tumor control, not all malignant tumors respond equally to radiation therapy: some patients do not derive clinical benefit from it because their tumors are constitutively insensitive to therapeutic doses of ionizing radiation, or are able to acquire such insensitivity.…”