Primary structure and synthesis of a blocked myotropic neuropeptide isolated from the cockroach, Leucophaea maderae

Holman, G. Mark; Cook, Benjamin J.; Nachman, R.J.

doi:10.1016/0742-8413(86)90077-0

Cited by 152 publications

(83 citation statements)

References 5 publications

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“…Myosuppressins were originally identi fi ed as a neuropeptide with a FLRFamide car-boxy terminus that can inhibit hindgut contractions of in cockroaches (Holman et al 1986 ) .…”

Section: Neuropeptide Gpcrsmentioning

confidence: 99%

G Protein-Coupled Receptors as Target Sites for Insecticide Discovery

Bai

Palli

2012

Advanced Technologies for Managing Insect Pests

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“…Myosuppressins were originally identi fi ed as a neuropeptide with a FLRFamide car-boxy terminus that can inhibit hindgut contractions of in cockroaches (Holman et al 1986 ) .…”

Section: Neuropeptide Gpcrsmentioning

confidence: 99%

G Protein-Coupled Receptors as Target Sites for Insecticide Discovery

Bai

Palli

2012

Advanced Technologies for Managing Insect Pests

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“…FXPRLamides can also influence the motility of insect visceral muscles (Nachman and Holman, 1991;Schoofs et al, 1993). Such myotropic peptides, known from various hemimetabolous insects (Table 1), are designated here as pyrokinins, after the first identified member of this peptide family (Holman et al, 1986).…”

mentioning

confidence: 99%

Tagma-specific distribution of FXPRLamides in the nervous system of the American cockroach

Predel

Eckert

2000

J. Comp. Neurol.

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“…While originally isolated from insects (e.g. Holman et al, 1986), members of the PBAN/diapause hormone/pyrokinin/ periviscerokinin superfamily have also been identified in a variety of crustaceans (Christie, 2014a(Christie, ,b, 2013Cooke, 2002;Hui et al, 2012;Ma et al, 2009Ma et al, , 2010Ma et al, , 2008Saideman et al, 2007;Christie and Chi, 2015). In members of the Decapoda, 20 pyrokinin-like peptides are known, with essentially all being amino (N)-terminally extended variants of the FXPRLamide consensus motif (Christie, 2014a;Hui et al, 2012;Ma et al, 2009Ma et al, , 2010Ma et al, , 2008Saideman et al, 2007;Torfs et al, 2001;Christie and Chi, 2015).…”

Section: Introductionmentioning

confidence: 99%

Distinct or shared actions of peptide family isoforms: I. Peptide-specific actions of pyrokinins in the lobster cardiac neuromuscular system

Dickinson

Sreekrishnan

Kwiatkowski

et al. 2015

Journal of Experimental Biology

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Although the crustacean heart is modulated by a large number of peptides and amines, few of these molecules have been localized to the cardiac ganglion itself; most appear to reach the cardiac ganglion only by hormonal routes. Immunohistochemistry in the American lobster Homarus americanus indicates that pyrokinins are present not only in neuroendocrine organs ( pericardial organ and sinus gland), but also in the cardiac ganglion itself, where pyrokinin-positive terminals were found in the pacemaker cell region, as well as surrounding the motor neurons. Surprisingly, the single pyrokinin peptide identified from H. americanus, FSPRLamide, which consists solely of the conserved FXPRLamide residues that characterize pyrokinins, did not alter the activity of the cardiac neuromuscular system. However, a pyrokinin from the shrimp Litopenaeus vannamei [ADFAFNPRLamide, also known as Penaeus vannamei pyrokinin 2 (PevPK2)] increased both the frequency and amplitude of heart contractions when perfused through the isolated whole heart. None of the other crustacean pyrokinins tested (another from L. vannamei and two from the crab Cancer borealis) had any effect on the lobster heart. Similarly, altering the PevPK2 sequence either by truncation or by the substitution of single amino acids resulted in much lower or no activity in all cases; only the conservative substitution of serine for alanine at position 1 resulted in any activity on the heart. Thus, in contrast to other systems (cockroach and crab) in which all tested pyrokinins elicit similar bioactivities, activation of the pyrokinin receptor in the lobster heart appears to be highly isoform specific.

show abstract

Primary structure and synthesis of a blocked myotropic neuropeptide isolated from the cockroach, Leucophaea maderae

Cited by 152 publications

References 5 publications

G Protein-Coupled Receptors as Target Sites for Insecticide Discovery

G Protein-Coupled Receptors as Target Sites for Insecticide Discovery

Tagma-specific distribution of FXPRLamides in the nervous system of the American cockroach

Distinct or shared actions of peptide family isoforms: I. Peptide-specific actions of pyrokinins in the lobster cardiac neuromuscular system

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