Primary Squamous Cell Carcinoma of Lung Leading to Metastatic Jaw Tumor

Abstract

Metastatic tumors to the orofacial region are unusual and they may occur in the oral soft tissues or jaw bones. Owing to their clinical variability the diagnosis of such tumors is often a dilemma. We report a unique case of mandibular metastasis which became the first evidence of an occult primary in the lung.

Metastatic adenocarcinoma of mandible: in search of the primary

“…Similar cases of unknown primary with a metastatic lesion in the mandible have been reported previously 4–10. Most common symptoms reported were swelling and altered sensation 3.…”

“…Multiple lesions in both jaws were reported in a case of metastatic bronchoalveolar carcinoma 4. The presence of systemic symptoms like cough may give a clue in the diagnosis of the primary lesion 7. Radiographically, ill-defined radiolucency or moth-eaten appearance was seen in cases of metastatic lung carcinomas while metastases from prostate and breast can show mixed radiolucent radio-opaque appearance 11.…”

Unusual Presentation of an Adenocarcinoma of the Lung Metastasizing to the Mandible, Including Molecular Analysis and a Review of the Literature

“…Twenty-four articles were identified from 1,482 publications [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. The distribution of the 24 publications that entered the final review is as follows: case reports (n: 11), review data from a single institution (n: 11), review data from three institutions (n: 1), systematic reviews or data from multiple institutions (n: 1).…”

Metastatic Tumours to the Oral Cavity: Report of Three Cases

“…The oral cavity is an uncommon site for metastatic tumours and it may occur both in the oral soft tissues or the jawbones. Because of their rarity, metastatic tumours to the oral region, pose a challenge for accurate diagnosis [ 4 , 8-12 ].…”