Metastatic adenocarcinoma of mandible: in search of the primary

Savithri, Vindhya; Suresh, R.; Janardhanan, Mahija; Aravind, Thara

doi:10.1136/bcr-2018-227862

Cited by 6 publications

(6 citation statements)

References 11 publications

(17 reference statements)

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“…19,27 Metastatic lesions can be found anywhere in the oral cavity, yet 90% of them have an intraosseous localization, while soft tissue localizations are rare. 28 Labrador et al in a more recent review estimate that osseous invasion corresponded to 65%-75% of the cases, while soft tissue invasion corresponded to 25%-35%. It is quite impossible to determine whether these are primarily soft tissue or bone tissue lesions because it is often a combination of soft and bone tissue involvement.…”

Section: Discussionmentioning

confidence: 95%

“…Specifically, Kanth et al suggested that the main mechanism of hematogenous metastasis to the oral cavity involves Batson's venous plexus, the valveless prevertebral venous network that permits the retrograde path of tumour cells from the lungs to the face 19,27 . Metastatic lesions can be found anywhere in the oral cavity, yet 90% of them have an intraosseous localization, while soft tissue localizations are rare 28 . Labrador et al in a more recent review estimate that osseous invasion corresponded to 65%–75% of the cases, while soft tissue invasion corresponded to 25%–35%.…”

Section: Discussionmentioning

confidence: 99%

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Mandibular metastasis of pulmonary adenocarcinoma: How unexpected could it be?

et al. 2023

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ObjectiveMetastatic tumours of bone must be considered in all patients with unexplained bone pain and particularly in patients who present with a known cancer, localised pain at multiple sites, and radiographic findings suggestive of metastasis. The purpose of this report was to present a case of a pathological fracture of the mandible as a consequence of metastatic pulmonary adenocarcinoma.Materials and MethodsIn July 2018 a 68‐year‐old male patient was hospitalised because of pulmonary adenocarcinoma and attended our department for an oral maxillo‐facial evaluation. He complained of pain and swelling in the right temporomandibular region resulting in a reported functional limitation.An Orthopantomogram (OPG) demonstrated a right intracapsular condylar compound fracture associated with an osteolytic lesion at the condyle base with jagged margins. Subsequently, a CT scan with contrast of the maxillo‐facial complex and a fine‐needle aspiration of the lesion was performed.ResultsCT images showed the presence of a right mandibular condyle fracture associated with a large osteolytic lesion which confirmed the pathological nature of the fracture. Fine‐needle aspiration of the lesion confirmed its metastatic nature. It was not possible to proceed with a mandibular resection due to the critical clinical condition of the patient who died in September 2018.ConclusionLung cancer frequently produces lytic‐type metastasis, sometimes even in the jaw. In patients with an established diagnosis of lung cancer, any radiolucent lesion of the jaw or an unexplained painful symptomatology to the oro‐maxillo facial complex should be placed in differential diagnosis with metastasis of the primary tumour.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Mandibular metastasis of pulmonary adenocarcinoma: How unexpected could it be?

et al. 2023

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“…Oral cavity metastasis typically has a poor prognosis, with most patients dying within one year of diagnosis (35)(36)(37)(38)(39)(40)(41)(42)(43). The prognosis depends on the treatment of the oral cavity lesion, as well as adequate control of the primary tumor and metastasis (advanced disease) (35)(36)(37)(38)(39)(40)(41)(42)(43)52).…”

Section: Discussionmentioning

confidence: 99%

“…The subsequent literature review primarily focused on studies published in English, although those published in other languages were also evaluated for relevance and new information. No restrictions regarding the publication date were applied, with the earliest study being published in 1961, and the findings of the literature search were summarized in Table II (35)(36)(37)(38)(39)(40)(41)(42)(43).…”

Section: Literature Search Strategy Multiple Databases Includingmentioning

confidence: 99%

Metastatic gallbladder cancer presenting as numb chin syndrome: A case report and literature review

Murahashi,

Ntege,

Ide

et al. 2024

Biomed Rep

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Gallbladder cancer (GBC) is an uncommon malignancy that is highly aggressive in the advanced stages. However, it rarely metastasizes to the mandible. Numb chin syndrome (NCS) is a rare neurological manifestation associated with various underlying causes, including occult primary cancers and distant metastases. It is often considered to be a significant indicator of malignancy, and thorough investigation is essential in the presence of unclear etiology. The current study reported on the case of a 69-year-old Japanese woman who presented with numbness and mild pain in the lower lip and chin area for three months. No other systemic symptoms were observed. Immunocytochemical examination revealed the presence of an adenocarcinoma and TNM staging as per the Union for International Cancer Control and the American Joint Committee on Cancer guidelines confirmed stage IVb GBC. Comprehensive full-body positron emission tomography-computed tomography examination using 18 F-fluoro-2-deoxy-D-glucose revealed additional bone and soft-tissue metastases. Palliative chemotherapy and radiation treatment were initiated based on the advanced stage of disease at the time of diagnosis. However, the patient succumbed to multiple organ failure six months later. The simultaneous occurrence of GBC, mandibular metastasis and NCS is rare and associated with poor prognosis. Despite the widespread nature of the disease, it can often manifest as non-specific oral symptoms without any systemic indications. The current study emphasizes the critical importance of timely confirmatory testing for accurate diagnosis and initiation of appropriate management for such complex conditions.

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“…4 Metastatic lesions can be found anywhere in the oral cavity, yet 90% are intraosseous and within the mandible and soft tissue localizations are rare. 5 Metastatic foci in the jaw bones are mainly situated in the red marrow, where there is hematopoietically active bone marrow. 6 The ascending ramus and angle of the posterior mandible as well as focal osteoporotic bone marrow defects are the most hematopoietically active sites that attract tumor cells, thus accounting for their higher tendency to seed within these sites.…”

Section: Discussionmentioning

confidence: 99%

Mandibular metastasis from lung adenocarcinoma as the first sign of occult malignancy

Johnson

Read-Fuller

2020

Baylor University Medical Center Proceedings

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Metastatic disease to the oral and maxillofacial region is rare, with only about 1% of oral malignancy attributed to metastases. In approximately 20% of these patients, oral metastases are discovered before the detection of the primary tumor. Here we present a case of a 66-year-old man who presented with vague left mandibular pain and new-onset lip numbness as the first sign of occult malignancy from lung adenocarcinoma with multiple metastases.

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Metastatic adenocarcinoma of mandible: in search of the primary

Cited by 6 publications

References 11 publications

Mandibular metastasis of pulmonary adenocarcinoma: How unexpected could it be?

Mandibular metastasis of pulmonary adenocarcinoma: How unexpected could it be?

Metastatic gallbladder cancer presenting as numb chin syndrome: A case report and literature review

Mandibular metastasis from lung adenocarcinoma as the first sign of occult malignancy

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