Primary squamous cell carcinoma of the liver: A case report and review of the literature

Zhao, Rongrong; Zhu, Kangshun; Wang, Renben; Gao, Jie; Cui, Kai; Yu, Fa-Chang; Zhang, Bo; Li, Sheng

doi:10.3892/ol.2012.894

Cited by 13 publications

(20 citation statements)

References 10 publications

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“…7 Pathogenesis of primary SCC of the liver is not entirely clear but previous cases have been associated with various diseases including non-parasitic cysts, hepatic cirrhosis, hepatolithiasis, hepatic teratoma, and Caroli's disease. 7,8 There has been only one reported case of primary SCC without latent hepatic insult. 7…”

Section: Introductionmentioning

confidence: 99%

“…Hepatic primary SCC is highly malignant with high rates of recurrence and poor overall prognosis. 8 The disease state is typically advanced upon diagnosis and presents clinically as right upper quadrant pain, vague fullness, jaundice, weight loss, nausea, and/or vomiting. Hepatomegaly and tenderness with palpitation may be present.…”

Section: Introductionmentioning

confidence: 99%

“…7 The outcomes of cases in the literature suggest a prognosis of less than 1 year survival with only isolated cases achieving 5 year survival. 7,8 There is no current treatment standard, but most commonly, TACE, surgical resection, and radiation therapy have been utilized. 7,8 …”

Section: Introductionmentioning

confidence: 99%

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Ciliated hepatic cyst leading to squamous cell carcinoma of the liver – A case report and review of the literature

Wilson

Groeschl

George

et al. 2013

International Journal of Surgery Case Reports

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INTRODUCTIONCiliated hepatic foregut cysts (CHFC) are rare, typically benign liver lesions. Primary squamous cell carcinoma (SCC) of the liver is also a rare entity with only approximately 25 reported cases in the literature. Recently, there have been four reports of malignant transformation of CHFC into primary squamous cell carcinoma of the liver. Here we report a fifth with unique presentation and review the literature.PRESENTATION OF CASEA 34 year-old man, with a history of ulcerative colitis, was incidentally found to have a 10 cm lesion in the right anterior sector plus left medial section of the liver on computerized tomography (CT) scan. The patient was asymptomatic at presentation and neoplastic markers were not elevated. Sequential transarterial chemoembolization (TACE) and portal vein embolization (PVE) allowed for left lateral section plus segment 1 hypertrophy and subsequent resection. Histology later revealed the cyst to be a CHFC and showed its malignant transformation. At 6 month follow-up, the patient has lung and abdominal recurrence.DISCUSSIONWith now the fifth case of malignant transformation of CHFC being reported, approximately 5% of all reported CHFC have undergone malignant transformation. This frequency, taken together with the aggressive disease course and poor prognosis, suggests that CHFC must not be presumed benign and should be regarded with clinical suspicion.CONCLUSIONAccurate diagnosis of CHFC is mandatory given its potential malignant transformation. Even in asymptomatic CHFC, surgical excision is recommended. In addition, in cases of otherwise unresectable lesions, sequential TACE and PVE may provide optimal hypertrophy of future liver remnant.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ciliated hepatic cyst leading to squamous cell carcinoma of the liver – A case report and review of the literature

Wilson

Groeschl

George

et al. 2013

International Journal of Surgery Case Reports

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“…According to the past studies, patients with primary SCC of the liver may present various symptoms including abdominal pain or discomfort, jaundice, weight loss, loss of appetite, and rarely, progressive dysphagia. Thorough physical examination might be able to find palpable abdominal mass and tenderness over right upper quadrant, with fever [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Primary squamous cell carcinoma of the liver: a case report

et al. 2016

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Primary squamous cell carcinoma (SCC) of the liver is very rare, and few cases have been reported in Korea. Primary SCC of the liver is known to be associated with hepatic cysts and intrahepatic stones. A 71-year-old male was admitted to our hospital, and a abdominal computed tomography scan revealed a 10 × 6 cm mass in the liver. Analysis of a biopsy sample suggested SCC, and so our team performed a thorough workup to find the primary lesion, which was revealed hepatoma as a pure primary SCC of the liver with multiple distant metastases. The patient was treated with one cycle of radiotherapy, transferred to another hospital for hospice care, and then died 1 month after discharge.

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“… 28 Chemotherapy, TACE, and even radiation could be used in these inoperable patients or as adjuvant treatments before and after surgery. 20 , 23 , 25 , 27 – 29…”

Section: Discussionmentioning

confidence: 99%

Primary Squamous Cell Carcinoma of Liver

Zhang

Liu

et al. 2015

Medicine

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Primary squamous cell carcinoma (SCC) of liver is rare, and its prognosis is extremely poor. This study aims at reviewing the clinical data of all pathologically diagnosed liver cancer in our institute, and discussing the clinical presentation, diagnosis, treatment, and prognosis of our cases of SCC and the literatures reported previously.All the patients undergoing liver surgery or biopsy for liver cancers from 2002 to 2013 in our hospital were reviewed, and the liver specimens were examined pathologically. A literature search for case reports of primary SCC of liver published until December 31, 2014, was performed on PubMed, MEDLINE, Scopus Elsevier, Cochrane, and Google Scholar. The primitive data of the case reports were all included and analyzed if available.From January 2002 to October 2013, 2210 cases of liver cancer were diagnosed pathologically in our hospital. Among, 4 cases (0.2%) were diagnosed as primary SCC of liver. All were negative for hepatitis B infection, but present with liver cyst and/or hepatolithiasis. One patient underwent radical resection, but died of tumor recurrence 18 months postoperatively. One patient received transcatheter arterial chemoembolization and 1 patient received laparotomy and alcohol injection, but died 9 and 4 months after surgery, respectively. The last patient received only biopsy and supportive treatment, and finally died of tumor metastasis 6 months later. From 1970 to 2014, 31 cases of primary liver SCC have been published in English previously. Thirty one cases and the 4 cases in the present study were included. The average age of the patients were 54 years (range 18–83), with a male to female ratio of 19:16. Twenty patients had liver cysts, 7 had bile duct stones, and 2 cases had both. Patients undergoing radical surgery had better prognosis than those undergoing palliative treatments (median survival 17 vs 5 months, P = 0.005, log-rank test). Patients with liver cysts seemed to have worse prognosis than those with bile duct stones (median survival 7 vs 18 months, P = 0.090, log-rank test).Primary liver SCC seems to be mostly originated from liver cyst or hepatolithiasis. Radical surgery should be firstly recommended, although the prognosis might be unfavorable.

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Primary squamous cell carcinoma of the liver: A case report and review of the literature

Cited by 13 publications

References 10 publications

Ciliated hepatic cyst leading to squamous cell carcinoma of the liver – A case report and review of the literature

Ciliated hepatic cyst leading to squamous cell carcinoma of the liver – A case report and review of the literature

Primary squamous cell carcinoma of the liver: a case report

Primary Squamous Cell Carcinoma of Liver

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