Primary squamous cell carcinoma of the stomach

Squamous cell carcinoma (SCC) of the stomach is a rare entity. There are several theories regarding the development of this tumor, but its pathogenesis remains obscure. Fewer than 100 cases of primary SCC of the stomach have been published in the literature. Due to advanced stage at the time of diagnosis in most of these cases, the prognosis is generally poor. In the case presented here, endoscopy revealed a vegetative tumor in the stomach described as SCC by biopsy. Following curative surgery, adjuvant chemotherapy was administered; however, the patient died 3 years and 4 months after surgery after recurrence was diagnosed.

show abstract

“…Since then, not much has changed, although several theories have been proposed referred to this respect. 4 , 13 , 14 …”

Section: Introductionmentioning

confidence: 99%

Primary Squamous Cell Carcinoma of the Stomach

González-Sánchez

Vitón

Collantes

et al. 2017

Clin Med Insights Oncol

View full text Add to dashboard Cite

show abstract

“…The overall survival rate ranges from seven months to eight years [13]. Although the primary treatment is surgery, it seems that adjuvant chemotherapy (5-fluorouracil, leucovorin, cisplatin, and etoposide) can enhance survival rates [13]; however, there is insufficient evidence to confirm this claim.…”

Section: Discussionmentioning

confidence: 99%

Primary Squamous Cell Carcinoma of the Stomach: A Case Report

Fernandes,

Morais,

Campos

et al. 2024

Cureus

View full text Add to dashboard Cite

Gastric squamous cell carcinoma (SCC) is a rare and puzzling entity that challenges conventional paradigms of gastric malignancies, especially in young adults. This case report presents a 22-year-old male with invasive SCC of the stomach, emphasizing the rarity of such occurrences and their diagnostic challenges. The literature review underscores the scarcity of information on gastric SCC, necessitating a critical examination of its clinical implications, etiological factors, and optimal management. The patient's complex medical history, diagnostic journey, and treatment course are detailed, highlighting the importance of multidisciplinary collaboration and advanced diagnostic techniques. Immunohistochemistry is a crucial tool for precise tumor characterization, and the absence of established risk factors emphasizes the enigmatic nature of gastric SCC. This case report contributes to the understanding of gastric SCC, prompting further research into its unique features, etiology, and therapeutic strategies in the context of gastric cancer.

show abstract

“…P63 tumor marker has been shown to be positive in 81% of squamous cell carcinomas [7] (Figure 3(a)). Moreover, P40 positivity has been shown to improve diagnostic yield for squamous cell carcinoma in poorly differentiated carcinomas, as well as differentiate squamous cell carcinoma from adenocarcinoma [8–10](Figure 3(b)).…”

Section: Discussionmentioning

confidence: 99%

Metastatic Primary Gastric Squamous Cell Carcinoma: An Uncommon Presentation of a Rare Malignancy

Beattie

Mansour

Thigpin

et al. 2019

Case Reports in Gastrointestinal Medicine

View full text Add to dashboard Cite

Primary gastric squamous cell carcinoma is a very rare disease. A 53-year-old male with history of hypertension, alcoholism, and nicotine abuse presented to the hospital after a syncopal episode. He complained of bloating abdominal pain, early satiety, and poor appetite. A CT of his abdomen and pelvis revealed a gastric mass with diffuse hepatic metastasis. A gastric mass was seen on upper endoscopy and biopsies revealed gastric squamous cell carcinoma. There was no involvement of the esophagus. This case should add to the limited literature and serve as a reminder that while this is a rare malignancy, it must be considered when evaluating a gastric mass.

show abstract

Primary squamous cell carcinoma of the stomach

Cited by 10 publications

References 7 publications

Primary Squamous Cell Carcinoma of the Stomach

Primary Squamous Cell Carcinoma of the Stomach

Primary Squamous Cell Carcinoma of the Stomach: A Case Report

Metastatic Primary Gastric Squamous Cell Carcinoma: An Uncommon Presentation of a Rare Malignancy

Contact Info

Product

Resources

About