Primary squamous cell carcinoma of the liver occurring in association with hepatolithiasis

Song, E; Kew, Michael C.; Grieve, Tom; Isaacson, C.; Myburgh, J. A.

doi:10.1002/1097-0142(19840201)53:3<542::aid-cncr2820530328>3.0.co;2-3

Cited by 37 publications

(23 citation statements)

References 7 publications

(2 reference statements)

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“…11 Most hepatic squamous cell carcinomas are thought to arise from pathologic biliary tree or cyst lining epithelia showing squamous metaplasia caused by chronic inflammation. 3,7,14 The background liver in our patient was histologically almost normal at autopsy, except for bilirubinostasis.…”

Section: Discussionmentioning

confidence: 99%

“…Primary squamous cell carcinoma of the liver has been reported rarely, and it is usually associated with preceding hepatic lesions, such as hepatic cysts. [1][2][3][4][5][6][7][8][9][10][11][12] Hypercalcemia associated with parathyroid hormonerelated protein (PTHrP) is also uncommon as a paraneoplastic liver tumor syndrome. 13 We report here an autopsy case of primary squamous cell carcinoma of the liver in a patient with marked hypercalcemia associated with an increased serum level of PTHrP; immunohistochemically, there was expres-27.5 ng/ml (NR, Ͻ5 ng/ml), and squamous cell carcinoma-related antigen (SCC) was also elevated, to 5.3 ng/ml (NR, Ͻ2 ng/ml).…”

Section: Introductionmentioning

confidence: 99%

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Primary squamous cell carcinoma of the liver producing parathyroid hormone-related protein

Saito

Harada

Tsuneyama

et al. 2002

Journal of Gastroenterology

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We report here an autopsy case of primary squamous cell carcinoma of the liver in a 63-year-old man who had hypercalcemia and an elevated serum level of parathyroid hormone-related protein. At autopsy, primary squamous cell carcinoma of the liver was found, without distinct preceding or associated hepatic or biliary diseases; no extrahepatic primary focus of squamous cell carcinoma was found. Bone involvement was not demonstrated, either radiologically or pathologically. Immunohistochemically, parathyroid hormone-related protein was detectable in the squamous cell carcinoma cells and it may have been responsible for the hypercalcemia. Such a case has not been reported so far in the English-language or the Japanese literature.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Primary squamous cell carcinoma of the liver producing parathyroid hormone-related protein

Saito

Harada

Tsuneyama

et al. 2002

Journal of Gastroenterology

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“…Continuous irritation due to chronic infection, followed by metaplastic changes in the biliary epithelium, has been thought to lead to neoplasia. 5,[24][25][26] On the other hand, Barr and Hancock 27 and others 8,13 suggested that ASCs arose from squamous metaplasia of adenocarcinoma cells because there was no normal epithelium in the tumors, and the tumors contained only adenocarcinoma, adenocarcinoma metaplasia, and squamous cell carcinoma components. In the present microscopic study, there was no normal epithelium, and this tumor contained only adenocarcinoma and squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Primary adenosquamous carcinoma of the liver: case report

Suzuki

Hirai

Ota

et al. 2002

Journal of Hepato-Biliary-Pancreatic Surgery

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We describe a case of adenosquamous carcinoma of the liver, including treatment for the recurrence. A 67-year-old man with prolonged high fever was diagnosed with a mass lesion in the left lobe of the liver seen by imaging studies. That mass lesion was histologically diagnosed as cholangiocarcinoma by needle biopsy. Left hepatic lobectomy was performed, and a tumor was found that measured 8.0 x 7.0 x 6.0 cm. It was a yellowish white solid mass without macroscopic invasion of the intrahepatic bile duct. Histological examination of the resected specimen revealed both adenocarcinoma and squamous cell carcinoma. The postoperative course was uneventful, but abdominal computed tomography 3 months after operation revealed seven masses in the remnant liver. We diagnosed recurrence of the tumor, and intrahepatic arterial infusion of cisplatin and 5-fluorouracil was begun. A partial remission resulted. Progression-free survival after chemotherapy lasted 2 months. However, the tumor markers and remnant tumor size increased gradually 9 months after the operation, and he died 14 months after surgery. We also review 41 cases of adenosquamous carcinoma of the liver reported in the Japanese and English language literature, including the present case.

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“…The pathogenesis of the disease is undetermined. Previous studies have reported that potentially related diseases, including congenital cyst of the liver (2)(3)(4)(5)(6)(7)(8), calculus of the intrahepatic duct (9), hepatic cirrhosis (10,11), Caroli's disease (12) and hepatic teratoma (1), are rare. However, hepatic primary squamous carcinoma without latent hepatic injury has also been reported (13).…”

Section: Introductionmentioning

confidence: 99%

Primary squamous cell carcinoma of the liver: A case report and review of the literature

et al. 2012

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Abstract. Primary squamous cell carcinoma of the liver is rare. It has a high malignancy rate and poor prognosis, and survival is typically no longer than one year. The pathogenesis of the disease is unclear, but is generally considered to be correlated with the long-term inflammation or metaplasia of biliary epithelial cells and congenital cyst of the liver. The current viewpoint is that surgical resection of the tumor, preoperative or postoperative subsidiary chemoembolization, radiotherapy and generalized chemotherapy may extend a patient's survival. In the present case study, a patient suffered from biliary calculosis for over 20 years. We theorized that the mechanism of carcinomatous change was correlated with the persistent stimulation of chronic biliary infection induced by calculus of the intrahepatic duct. However, the transformation mechanism from cholangiocellular carcinoma to squamous carcinoma is undetermined and further studies are needed.

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Primary squamous cell carcinoma of the liver occurring in association with hepatolithiasis

Cited by 37 publications

References 7 publications

Primary squamous cell carcinoma of the liver producing parathyroid hormone-related protein

Primary squamous cell carcinoma of the liver producing parathyroid hormone-related protein

Primary adenosquamous carcinoma of the liver: case report

Primary squamous cell carcinoma of the liver: A case report and review of the literature

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