Primary spinal peripheral primitive neuroectodermal tumor with acute presentation: A case report and review of literature

Bachchan, Abta; Roy, Kaushik; Saha, Suniti Kumar; Pathak, Debajyoti; Ghosh, Pradip N.; Nadkarni, Abhishek

doi:10.3126/ajms.v10i3.22896

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…Primary spinal PNETs are a rare entity with a poor prognosis [ 13 ]. Pathological findings were suggestive of PNET in our patient after correlation of histology and IHC showing CD99, FLi1 to be strongly positive.…”

Section: Discussionmentioning

confidence: 99%

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Piecing Together a Puzzle of Exceptional Lesions: A Retrospective Study of a Potpourri of 160 Space-Occupying Lesions of the Central Nervous System

Gore¹,

Mishra²,

Rashmi³

et al. 2022

Cureus

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Introduction Central nervous system (CNS) lesions are rare and histologically heterogenous, and carry serious potential for patient morbidity and mortality. A retrospective epidemiological review of CNS neoplasms is of great importance for future research because it can demonstrate the changes in the spectrum of CNS lesions of a population, unveil the possible associated risk factors, and indicate the potential therapeutic methods for various neoplastic and non-neoplastic lesions. Neurosurgeons have always shown an obsession with a good neuropathological diagnosis in intracranial and extracranial lesions. This obsession need not be overemphasized as it helps the clinician plan an adequate surgical/treatment strategy to optimize outcomes and minimize morbidity. Methods This study included a spectrum of 160 biopsies of patients with space-occupying lesions of the CNS during a period of two years (2019-2021). All the cases were studied and analyzed, and their histological typing/grading was done. The cases were graded and categorized according to the 2016 WHO Classification of CNS Tumors. Results Among 160 cases, the study showed a slight male preponderance of 100 (62.5%) cases. The maximum number of cases, 37 (23%) cases, was in the age group of 41-50 years. Clinically, the commonest complaints were headache and seizures. The most common location of tumor was supra-tentorial, comprising around 96 (60%) cases, of which 27 (28%) cases were located in the frontal lobe. There were four (2.5%) cases that had non-neoplastic lesions and the rest 156 (97.5%) cases had neoplastic lesions. Malignant lesions outnumbered the benign lesions, comprising of 82 (51.25%) cases. Among the neoplastic lesions, the highest cases were of astrocytoma, 48 (30.76%) cases, followed by meningioma, 42 (26.92%) cases. Also, 21 extremely rare and unusual cases were encountered. Conclusion The present study reflects the diversity of histopathological spectrum of CNS lesions in our center. In-depth studies from across various hospitals are required to have representative data on the incidence, epidemiological profile, and etiology of CNS lesions in India.

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Section: Discussionmentioning

confidence: 99%

“…Thoracic spinal psammomatous meningioma is also a rare subtype of meningioma. Psammomatous meningiomas are very rare tumors that complicate the surgical removal in certain cases, yet they are a curable pathology and carry a good prognosis if completely excised (Figure 4 ) [ 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

Piecing Together a Puzzle of Exceptional Lesions: A Retrospective Study of a Potpourri of 160 Space-Occupying Lesions of the Central Nervous System

Gore¹,

Mishra²,

Rashmi³

et al. 2022

Cureus

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“…Clinically, pPNET is rarely involved in the spine, and many authors describe spinal pPNET as "extremely rare". The most commonly involved sites are the lumbar spine, followed by the thoracic and cervical vertebrae [2]. Due to its low incidence, most of the related literature consists of case reports [19].…”

Section: Introductionmentioning

confidence: 99%

Primary spinal peripheral primitive neuroectodermal tumour: a report of 3 cases and review of the literature

Cui

Zhao

2022

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Peripheral primitive neuroectodermal tumours (PNETs) are rare and highly malignant tumours in the spine, with a predilection for young adults. There are no standard guidelines for treating these tumours. Surgical resection combined with postoperative radiotherapy and chemotherapy is a common and effective treatment at present. Even so, survival time of patients with these tumours is still very short. In this study, we present three rare cases of thoracic epidural PNETs and review the literature.

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Primary spinal peripheral primitive neuroectodermal tumor with acute presentation: A case report and review of literature

Cited by 2 publications

References 8 publications

Piecing Together a Puzzle of Exceptional Lesions: A Retrospective Study of a Potpourri of 160 Space-Occupying Lesions of the Central Nervous System

Piecing Together a Puzzle of Exceptional Lesions: A Retrospective Study of a Potpourri of 160 Space-Occupying Lesions of the Central Nervous System

Primary spinal peripheral primitive neuroectodermal tumour: a report of 3 cases and review of the literature

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