Primary spinal melanoma with bilateral papilledema

Kounin, Gueorgui K.; Romansky, K.; Traykov, Latchezar; Shotekov, Penko; Stoilova, D.

doi:10.1016/j.clineuro.2004.10.013

Cited by 40 publications

(52 citation statements)

References 7 publications

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“…16) Forty cases of primary spinal malignant melanoma have been reported, [4][5][6]10,11,19,26) including 14 with dissemination from the primary CNS malignant melanoma. One case had liver and spleen metastases.…”

Section: Discussionmentioning

confidence: 99%

“…Primary CNS malignant melanoma has occurred in the spine, [4][5][6]10,11,19,26) suprasellar region, 3,6,24) cerebral region, 6,7,12,17) pineal region, 18) cerebellopontine angle, 13,25) spinal nerve root, 22,23) and leptomeninges. 16) Forty cases of primary spinal malignant melanoma have been reported, [4][5][6]10,11,19,26) including 14 with dissemination from the primary CNS malignant melanoma.…”

Section: Discussionmentioning

confidence: 99%

“…Primary spinal malignant melanoma is unusual, with the first case reported by Hirschberg in 1906, and only 40 cases since then. [4][5][6]10,11,19,26) The prognosis is poor, but primary CNS malignant melanoma including primary spinal malignant melanoma has a better prognosis than cutaneous melanoma. We treated a patient who presented with CNS dissemination 18 years after first treatment for primary spinal malignant melanoma.…”

Section: Introductionmentioning

confidence: 99%

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Long-Term Survival After Surgical Resection of Primary Spinal Malignant Melanoma -Case Report-

Nishihara

Sasayama

Kondoh

et al. 2009

Neurol. Med. Chir.(Tokyo)

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A 49-year-old man was admitted suffering from headache persisting for a month. He had a history of primary spinal intramedullary malignant melanoma at the T6 level 18 years previously, which had remained stable for 18 years. Magnetic resonance imaging revealed central nervous system (CNS) dissemination of malignant melanoma. Whole brain radiation therapy (30 Gy), local radiation therapy (15 Gy), and routine intrathecal injection of interferon beta were performed. The progression of CNS dissemination of malignant melanoma was controlled without neurological deterioration for 38 months. The prognosis for primary CNS malignant melanomas better than that for cutaneous melanoma. However, the clinical course is still unknown, and CNS dissemination is regarded fatal. The unusually long survival in the present case indicates the effectiveness of the combined radiotherapy and interferon therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Long-Term Survival After Surgical Resection of Primary Spinal Malignant Melanoma -Case Report-

Nishihara

Sasayama

Kondoh

et al. 2009

Neurol. Med. Chir.(Tokyo)

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“…Primary melanoma of the central nervous system is rare and accounts for approximately 1% of all cases of melanoma [7]. Primary melanoma of the spine is likely contained due melanocytes in the leptomeninges, which can easily spread into the local bone in a necrotic and destructive fashion.…”

Section: Discussionmentioning

confidence: 99%

Primary Malignant Melanoma of the Lumbar Spine

Ali¹

2017

Austin J Orthopade & Rheumatol

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Low Back Pain (LBP) or Lumbago is a leading cause of disability in the United States. There are several etiologies including but not limited to muscle strains, discherniation, vertebral instability and fractures. Most serious however are metastatic neoplastic processes, which invade the spine, spinal cord, and nerve roots potentially causing significant neurologic and functional compromise. Primary tumors of the spine are extremely rare, even rarer are primary melanomas of the spine [1]. We present a rare case of a 55-year-old male that was admitted with unrelenting back pain and inability to ambulate. Imaging shows pathologic L3 vertebral body compression fracture, biopsy confirmed malignant melanoma. Clinical examinations from dermatology, gastroenterology, ophthalmology, and oncology confirmed that there were no primary sources of the malignancy identified resulting in the spinal lesion being the only source and location of the tumor [1]. The patient's radicular symptoms and function improved post-operatively, patient was informed that data of his case will be submitted for publication. However, he later succumbed to a myocardial infarction two years later.

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“…Primary malignant melanomas involving the central nervous system are unusual, and account for approximately 1% of all cases of melanoma [5]. Only a few cases of primary malignant melanomas limited to the cervical spinal nerve root have been reported.…”

Section: Introductionmentioning

confidence: 99%

Findings from CT, MRI, and PET/CT of a primary malignant melanoma arising in a spinal nerve root

Lee

Hwang

et al. 2010

Eur Spine J

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Primary spinal malignant melanoma is an extremely rare condition. We here describe a case of a 71-year-old Asian female presenting with left upper extremity tingling sensation. Computed tomography (CT) showed a homogeneously enhanced mass occupying the left neural foramen at the C6-7 level. Magnetic resonance imaging revealed enhanced mass in intra-and extradural space compressing the spinal cord at this level. It also widened the neural foramen mimicking neurofibroma or schwannoma. Partial resection of the mass was performed. Pathologic diagnosis of the mass was malignant melanoma. Postoperative whole body positron emission tomography/ CT scan demonstrated an intense 18 F-FDG uptake at the residual mass site without abnormal uptake at other sites in the body.

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Primary spinal melanoma with bilateral papilledema

Cited by 40 publications

References 7 publications

Long-Term Survival After Surgical Resection of Primary Spinal Malignant Melanoma -Case Report-

Long-Term Survival After Surgical Resection of Primary Spinal Malignant Melanoma -Case Report-

Primary Malignant Melanoma of the Lumbar Spine

Findings from CT, MRI, and PET/CT of a primary malignant melanoma arising in a spinal nerve root

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