Findings from CT, MRI, and PET/CT of a primary malignant melanoma arising in a spinal nerve root

Lee, Nyoung Keun; Lee, Byung‐Hoon; Hwang, Yoon Joon; Sohn, Moon‐Jun; Chang, Sunhee; Kim, Yong Hoon; Joo, Soon; Cho, Hyeon Je

doi:10.1007/s00586-010-1285-1

Cited by 24 publications

(23 citation statements)

References 9 publications

(11 reference statements)

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“…The majority of tumors were solitary and only one patient with multiple foci was reported. 4 A few tumors originated from the nerve roots or had spinal nerve root involvement, [5][6][7][8][9] which led to the enlargement of the intervertebral foramen, and even spread outside the intervertebral foramen 2,10 or destruction of the vertebral pedicles. 8,11 Signs and symptoms of this tumor were nonspecific and dependent on location.…”

Section: Discussionmentioning

confidence: 99%

“…2 Clinically, PSM of extramedullary origin may be misdiagnosed as a neurogenic tumor (schwannoma), ependymoma, metastatic tumor, hematoma or meningioma. 3,[5][6][7][9][10][11][17][18][19] Ninety percent of melanomas found in the CNS are metastatic tumors. 8 A thorough physical examination is required to rule out melanoma in other organs outside of the spinal cord, before a diagnosis of PSM can be established.…”

Section: Discussionmentioning

confidence: 99%

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Primary spinal melanoma of extramedullary origin: a report of three cases and systematic review of the literature

et al. 2015

Spinal Cord Ser Cases

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STUDY DESIGN: A review of the literature and three case reports. OBJECTIVES: Primary spinal melanoma (PSM) of extramedullary origin is a rare malignant condition with limited current literature in regards to its clinical course, magnetic resonance imaging (MRI) findings, treatment strategies and prognosis. We reported here three cases of PSM of extramedullary origin. SETTING: China, Guangzhou. METHODS: We report three cases of PSM of extramedullary origin. The clinical and radiological findings of these cases were retrospectively analyzed. RESULTS: The three cases were all of males aged 39, 47 and 76 years, respectively. The duration of their symptoms was 3 weeks, 2 months and 11 months respectively. The extramedullary tumors were all well-defined solitary tumors and were located at C4-5, L2-3 and T9-10, respectively. In one case, involvement of the intervertebral foramen was found. Preoperative MRI showed hyperintense T1W signals and hypointense T2W signals in all three cases and all tumors were clinically misdiagnosed as schwannomas. The patients received total or subtotal resection surgery without radiotherapy or chemotherapy. Patients were alive at 18 months, 27 months and 36 months postoperative follow-up, respectively. CONCLUSION: PSM of extramedullary origin is a rare malignant tumor that shows characteristic findings on MRI. Surgical resection is the preferred treatment strategy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary spinal melanoma of extramedullary origin: a report of three cases and systematic review of the literature

et al. 2015

Spinal Cord Ser Cases

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“…In general, brain MRI of the tumors demonstrates diffuse thickening of the leptomeninges, which is iso- or hyperintense on T1-weighted images, hypointense on T2-weighted images, and abnormally enhancing on T1-weighted contrast-enhanced images (2, 17, 18). The paramagnetic effect of melanin pigment causes shortening of T1 and T2 relaxation times (7).…”

Section: Discussionmentioning

confidence: 99%

“…There is only one previous report involving F-18 PET/CT and primary malignant melanoma in a spinal cord root (18). Furthermore, there have been no reports involving F-18 FDG PET/CT and primary meningeal melanomatosis.…”

Section: Discussionmentioning

confidence: 99%

F-18 Fluorodeoxyglucose PET/CT and Post Hoc PET/MRI in a Case of Primary Meningeal Melanomatosis

et al. 2013

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Primary meningeal melanomatosis is a rare, aggressive variant of primary malignant melanoma of the central nervous system, which arises from melanocytes within the leptomeninges and carries a poor prognosis. We report a case of primary meningeal melanomatosis in a 17-year-old man, which was diagnosed with 18 F-fluorodeoxyglucose (F-18 FDG) PET/CT, and post hoc F-18 FDG PET/MRI fusion images. Whole-body F-18 FDG PET/CT was helpful in ruling out the extracranial origin of melanoma lesions, and in assessing the therapeutic response. Post hoc PET/MRI fusion images facilitated the correlation between PET and MRI images and demonstrated the hypermetabolic lesions more accurately than the unenhanced PET/CT images. Whole body F-18 FDG PET/CT and post hoc PET/MRI images might help clinicians determine the best therapeutic strategy for patients with primary meningeal melanomatosis.

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“…[4–7] Melanotic schwannoma, a variant of schwannoma, is characterized by the presence of spindle or epitheloid cell with pigmented granules. [6] Kasnatikul, in 1989, had reported a case of spinal melanotic arachnoid cyst, which was characterized by a melanotic cyst, lined with a cuboidal epithelium which was in continuation with the leptomeninges.…”

Section: Discussionmentioning

confidence: 99%

Melanotic cyst of L5 spinal root: A case report and review of literature

Chakravarthy

2012

Asian J Neurosurg

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Till date, 85 cases of melanotic schwannoma and 11 cases of spinal root melanoma have been reported in literature. We are reporting a case of a 45-year-old lady who presented with primary low back pain, and magnetic resonance imaging of lumbo-sacral spine showed at left L5-S1 foraminal lesion extending to the para-spinal compartment. Hemi-laminectomy, facetectomy, and excision of the lesion were done. It was primarily a cystic lesion with attachment to the exiting spinal nerve root. Histopathology of the cyst wall showed a fibro-collagenous stroma with no specific cell lining containing melanin pigment suggestive of a melanotic cyst. The patient was completely relieved of the back pain, and had no recurrence over a follow-up period of one and half years. This case is probably the first reported predominantly cystic, pigmented lesion, affecting the spinal root.

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Findings from CT, MRI, and PET/CT of a primary malignant melanoma arising in a spinal nerve root

Cited by 24 publications

References 9 publications

Primary spinal melanoma of extramedullary origin: a report of three cases and systematic review of the literature

Primary spinal melanoma of extramedullary origin: a report of three cases and systematic review of the literature

F-18 Fluorodeoxyglucose PET/CT and Post Hoc PET/MRI in a Case of Primary Meningeal Melanomatosis

Melanotic cyst of L5 spinal root: A case report and review of literature

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