Primary Small Cell Carcinoma of the Vagina

Oliveira, Rafael de Almeida; Bócoli, Mayra Coelho; Saldanha, João Carlos; Murta, Eddie Fernando Cândido; Nomelini, Rosekeila Simões

doi:10.1155/2013/827037

Cited by 12 publications

(25 citation statements)

References 15 publications

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“…SmCC vagina generally occurs in the postmenopausal age group and presents with vaginal discharge, metastatic symptoms or leucorrhoea 5 9. This patient presented to us with difficulty in passing stools due to the obstruction of the lumen by the extraneous mass.…”

Section: Discussionmentioning

confidence: 94%

“…But extra-pulmonary SmCC is rare and accounts for only 2.5% –5% of all SmCCs reported in the USA and an even meagre 0.1%–0.4% of all cancers 4. After an extensive search in the PubMed and MEDLINE database, we could find only 31 reported cases of primary SmCC of the vagina 5–7. Since the entity is so rare and sparsely studied, there is no established line of management.…”

Section: Introductionmentioning

confidence: 99%

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Primary small cell carcinoma of the vagina: a rare instance of prolonged survival

Kombathula¹,

Rapole

Prem

et al. 2019

BMJ Case Rep

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Small cell carcinoma (SmCC) of the vagina is a rare and aggressive tumour. It comprises only 1% –2% of all gynaecological malignancies 85% of the patients with SmCC vagina die within a year of diagnosis. Here we report the case of a 65-year-old woman with stage III primary neuroendocrine carcinoma of vagina who was treated with chemoradiotherapy. The patient survived 1 year and 10 months after the initial presentation. SmCC of the vagina is very rare and despite being aggressive, the local disease can be controlled with a chemoradiation regimen.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Primary small cell carcinoma of the vagina: a rare instance of prolonged survival

Kombathula¹,

Rapole

Prem

et al. 2019

BMJ Case Rep

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“…Small cell carcinoma is one of types of neuroendocrine cancers. Most common site is the lungs, accounting for 20% of lung cancers [1][2][3][4][5][6]. The small cell carcinoma is rare and accounts for 2% of malignancies diagnosed in the genital tract of female.…”

Section: Discussionmentioning

confidence: 99%

“…Neuroendocrine carcinoma of the genital tract of the female is rare, and most common sites were the ovary and uterine cervix in previous reports [1]. Primary neuroendocrine vaginal cancer is very rare, and approximately 40 cases have been reported [1][2][3][4][5][6]. There is no reported case of secondary neuroendocrine vaginal cancer.…”

Section: Introductionmentioning

confidence: 99%

Secondary small cell vaginal cancer after operative therapy for endometrial cancer

2020

EJGO

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Background: Gynecologic neuroendocrine carcinoma is rare. There is no case report of secondary small cell vaginal cancer after operative therapy for endometrial cancer. Case: A 51 year-old patient was treated by operative therapy for endometrial cancer stage IA (pT1aN0M0). After 9 months' post-treatment, the patient visited the hospital with abnormal bleeding, and a necrotic lesion in the left upper third of the posterior vaginal wall was detected near the vaginal cut edge. Biopsy of this tumor revealed neuroendocrine carcinoma, the patient was diagnosed with small cell carcinoma of the vagina stage I (pT1NXM0) by following operative resection. The patient received chemotherapy with irinotecan and cisplatin. After eleven months of follow-up, the patient remains alive without recurrence. Conclusion: In case of small cell vaginal cancer, chemotherapy regimen with irinotecan and cisplatin should be considered as a therapeutic option.

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“…Primary malignant epithelial tumors of the vagina are divided into three types: adenocarcinoma, squamous cell carcinoma, and small cell carcinoma [ 1 ]. Small cell carcinomas, which account for 1–2% of gynecological malignancies, occur with decreasing frequency in the cervix, endometrium, ovary, vagina, and vulva [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

RRx-001 Priming of PD-1 Inhibition in the Treatment of Small Cell Carcinoma of the Vagina: A Rare Gynecological Tumor

Brzezniak

Oronsky²,

Trepel

et al. 2017

Case Rep Oncol

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Small cell carcinoma of the vagina is rare, so rare in fact that the total number reported in English-language journals is less than 30. Due to this extremely low incidence, no specific treatment guidelines have been established, and most of what is clinically known is derived from a handful of single case reports. However, as befitting its highly aggressive histologic features, which are reminiscent of small cell lung cancer (SCLC), first-line treatment is modeled after SCLC. Herein is reported the case of a 51-year-old African-American patient with metastatic biopsy-proven small cell carcinoma of the vagina that progressed through multiple therapies: first-line cisplatin and etoposide (making it platinum-resistant) and radiotherapy, followed by the tumor macrophage-stimulating agent RRx-001 in a clinical trial called QUADRUPLE THREAT, which per protocol preceded a mandated rechallenge with cisplatin and etoposide. RECIST v.1.1 tumor progression on both RRx-001 and cisplatin/etoposide was accompanied by central necrosis in several of the enlarged lymph nodes and hepatic metastases, which may have been evidence of pseudoprogression, accounting for her ongoing longer-than-expected survival, since the necrotic tissue may have primed the activity of the PD-1 inhibitor. The lack of response to RRx-001 is hypothesized to have correlated with sparse tumor macrophage infiltration, seen on pre- and post-treatment biopsies, since the mechanism of action of RRx-001 relates to stimulation of tumor-associated macrophages.

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Primary Small Cell Carcinoma of the Vagina

Cited by 12 publications

References 15 publications

Primary small cell carcinoma of the vagina: a rare instance of prolonged survival

Primary small cell carcinoma of the vagina: a rare instance of prolonged survival

Secondary small cell vaginal cancer after operative therapy for endometrial cancer

RRx-001 Priming of PD-1 Inhibition in the Treatment of Small Cell Carcinoma of the Vagina: A Rare Gynecological Tumor

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