Primary skeletal muscle lymphoma: A case report

Abstract

Abstract. Primary lymphomas of the bone or skeletal muscle are rare. Three mechanisms of lymphomatous involvement of the muscle have been described, namely direct invasion from adjacent involved lymph nodes or bone, metastatic spread and, least commonly, primary muscle lymphoma. We herein present a rare case of primary mucle non-Hodgkin lymphoma with a description if the associated clinicopathological findings and a review of the relevant literature. A 41-year-old female patient was referred to our hospital with a painful mass in the right lower extremity. Following resection and histopathological examination, a diffuse large B-cell lymphoma originating from the muscle with cutaneous and subcutanenous infiltration was diagnosed. The patient received chemotherapy with six cycles of cyclophosphamide, hydroxydaunomycin, oncovin and prednisone (CHOP regimen) and a complete radiological response was achieved after six cycles of treatment.

Primary multifocal muscular T‐cell lymphoma with cutaneous involvement in a dog: A case report and review of the literature

“…The muscular lesions in the current case were also discrete masses rather than diffuse neoplastic infiltration within the muscle, and this is consistent with the findings of previous case reports of canine primary muscular lymphoma and human muscular lymphoma. [10][11][12] Primary skeletal muscle lymphoma is also a very rare neoplasia of people, accounting for only 0.5% of all extranodal lymphomas, with most cases usually being B-cell or non-Hodgkin's lymphoma. 13,14 This contrasts with the current case and three previously reported canine cases, two of which were T cell (one anaplastic large T-cell lymphoma and one low-grade T-cell lymphoma).…”

“…25 Different mechanisms of lymphomatous involvement of the muscle have been described, and the most common is the direct invasion from adjacent affected lymph nodes or bone, 22 with other mechanisms, including metastatic spread with disseminated disease and, least commonly, primary extranodal muscular lymphoma. 10 The pathogenesis of primary muscular lymphoma is unknown. Human skeletal muscle lymphoma tends to occur in the lower extremities, and one proposed explanation for this could be that the extremities are more prone to injuries, with human primary muscular lymphoma reported after soft tissue injury, 18 at drug injection sites, 13 and associated with the chronic inflammation of infections or immunemediated diseases.…”

Diagnosis of B‐cell lymphoma from gluteal muscle mass

“…Skeletal muscle is involved by lymphoma either in the course of disseminated disease, spread from contiguous lymph node or as a primary extranodal lesion. It seems that an aberrant lymph node in the skeletal muscle can lead to primary skeletal muscle lymphoma, while it is not detected histologically at the time of diagnosis . Skeletal muscle lymphoma generally arises in the extremities, especially lower limbs and in the thigh, since these extremities are most exposed to injuries .…”

Rare Presentations of Muscular Infiltrations in Classical Hodgkin’s lymphoma-A Case Series

“…The thighs, chest, and arms are the most frequent areas (1). There are three modes of lymphoma involvement in skeletal muscle reported, such as direct invasion from a nearby affected lymph node or bone, metastatic spread, and least frequently, primary muscular lymphoma (2). The majority of cases of metastatic muscle involvement are secondary (1).…”