Primary sjogren syndrome: Clinical and immunopathologic features

Fox, Robert I.; Howell, Francis V.; Bone, Robert C.; Michelśon, Paul E.

doi:10.1016/0049-0172(84)90001-5

Cited by 339 publications

(144 citation statements)

References 129 publications

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“…36 Nevertheless, abnormalities observed in large proportions of polyclonal CD4 þ T cells in murine as well as human SLE have been enigmatic considering that interaction of particular alleles of MHC class II genes is solely responsible for the positive selection of cryptic repertoire of autoreactive CD4 þ Th cells in SLE. Spontaneous activation of peripheral CD4 þ T cells is commonly associated with varieties of systemic autoimmune diseases such as rheumatoid arthritis, 37 SLE, [21][22][23][24] Sjogrens syndrome 38 and idiopathic portal hypertension. 39 In human SLE, expression of early activation marker CD69 on peripheral T cells is considered the phenotype most closely associated with the severity of the disease.…”

Section: Discussionmentioning

confidence: 99%

Genetic control of the spontaneous activation of CD4+ Th cells in systemic lupus erythematosus-prone (NZB × NZW) F1 mice

et al. 2006

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The F 1 hybrid of autoimmune hemolytic anemia-prone NZB and nonautoimmune NZW strains of mice has been studied as a murine model of systemic lupus erythematosus. Both NZB and F 1 hybrid mice show age-dependent spontaneous activation of peripheral CD4 þ T cells as reflected by the elevated frequencies of CD4 þ T cells positive for CD69 early activation marker. Both strains also show age-dependent abnormal decrease of the frequencies of CD62L þ naive CD4 þ T cells and/or NTA260 þ memory CD4 þ T cells in the spleen. We studied the multigenic control of these abnormal features of peripheral CD4 þ T cells in (NZB Â NZW) F 1 Â NZW backcross mice by quantitative trait loci mapping and by association rule analysis. The abnormally elevated frequencies of CD69 þ CD4 þ T cells and decreased frequencies of CD62L þ naive and/or NTA260 þ memory CD4 þ T cells were under the common genetic control, in which the interaction between MHC and a hitherto unknown locus, designated Sta-1 (spontaneous T-cell activation) on chromosome 12, plays a major role. The allelic effects of these loci likely predispose CD4 þ T cells to the loss of self-tolerance, and are responsible for the accelerated autoimmune phenotypes of (NZB Â NZW) F 1 hybrid mice.

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Section: Discussionmentioning

confidence: 99%

Genetic control of the spontaneous activation of CD4+ Th cells in systemic lupus erythematosus-prone (NZB × NZW) F1 mice

et al. 2006

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“…There are also clinical manifestations due to involvement of other exocrine glands or nonglandular tissues (2). The common hematological manifestations of primary Sjögren's syndrome are lymphopenia, leucopenia, and thrombocytopenia, but these changes are not usually of any clinical significance (1,2). This report describes a rare case of primary Sjögren's syndrome associated with autoimmune hemolytic anemia (AIHA).…”

Section: Introductionmentioning

confidence: 99%

“…Primary Sjögren's syndrome is a chronic inflammatory autoimmune disorder that predominantly affects the exocrine glands, and its classic pathological feature is the focal accumulation of lymphocytes in the lacrimal glands and salivary glands (1). There are also clinical manifestations due to involvement of other exocrine glands or nonglandular tissues (2).…”

Section: Introductionmentioning

confidence: 99%

Autoimmune Hemolytic Anemia in an Elderly Patient with Primary Sjoegren's Syndrome

et al. 2005

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“…Sjögren syndrome is an autoimmune disease, producing a range of autoantibodiesand cytokines leading to apoptosis of salivary and lacrimal tissues [1][2][3][4][5]. Current diagnostic tests are unable to render a specific diagnosis of SS and thus there is a need for improved diagnostic tools.…”

Section: Introductionmentioning

confidence: 99%

“…Sjögren syndrome (SS) is characterized by lymphocytic infiltration of the salivary and lacrimal glands by CD4 + T lymphocytes, loss or "drop out" of acinar secretory cells, and eventual fibrosis and destruction of the gland [1,2]. Sjögren syndrome is an autoimmune disease, producing a range of autoantibodiesand cytokines leading to apoptosis of salivary and lacrimal tissues [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

A-fodrinAutoantigen Detection in Saliva and on Salivary Ductal Cells in Sjögren Syndrome

McArthur¹

2016

J. Dent. Sci. Ther

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Background: Sjögren syndrome (SS) is an autoimmune exocrinopathy in which patients produce autoantibodies against the antigen α-fodrin. In the murine model the antigen that elicits the antibody response is a 120 kDacleaved α-fodrin fragment. In a human salivary gland (HSG) ductal cell in vitro model the α-chain of the protein fodrin is cleaved following TNF-induced apoptosis to yield a cleaved product. Cleaved α-fodrin is presented on the cell surface suggesting a mechanism for antigen recognition in vivo as well as a potential antigen of value in diagnosis. The objective of this study was to test the hypothesis that cleaved α-fodrin is expressed in minor salivary gland biopsies and saliva in vivo.

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Primary sjogren syndrome: Clinical and immunopathologic features

Cited by 339 publications

References 129 publications

Genetic control of the spontaneous activation of CD4+ Th cells in systemic lupus erythematosus-prone (NZB × NZW) F1 mice

Genetic control of the spontaneous activation of CD4+ Th cells in systemic lupus erythematosus-prone (NZB × NZW) F1 mice

Autoimmune Hemolytic Anemia in an Elderly Patient with Primary Sjoegren's Syndrome

A-fodrinAutoantigen Detection in Saliva and on Salivary Ductal Cells in Sjögren Syndrome

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