Autoimmune Hemolytic Anemia in an Elderly Patient with Primary Sjoegren's Syndrome

Kikawada, Masayuki; Watanabe, Daisuke; Kimura, A.; Hanyu, Haruo; Serizawa, Hiromi; Iwamoto, Toshihiko

doi:10.2169/internalmedicine.44.1312

Cited by 10 publications

(7 citation statements)

References 17 publications

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“…Among the autoimmune diseases, SLE is the major cause of secondary AIHA. However, AIHA is rarely reported in SS, 7–13 and only three previous reports have shown an association with primary SS 7,12,13 . Furthermore, warm‐type AIHA has not been previously described in primary SS.…”

Section: Discussionmentioning

confidence: 94%

“…However, AIHA is rarely reported in SS, [7][8][9][10][11][12][13] and only three previous reports have shown an association with primary SS. 7,12,13 Furthermore, warm-type AIHA has not been previously described in primary SS. SS is an autoimmune multisystem disorder associated with B lymphocyte hyper-reactivity, which result in chronic inflammation of the salivary and lachrymal glands and production of auto-antibodies such as anti-Ro/ SS-A, anti-La/SS-B.…”

Section: Discussionmentioning

confidence: 99%

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Severe autoimmune hemolytic anemia associated with IgM warm auto‐antibodies in primary Sjögren’s syndrome

et al. 2010

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Primary Sjögren's syndrome is an autoimmune disorder involving mainly salivary and lachrymal glands. However, many extraglandular symptoms have also been reported. Although leucocytopenia and lymphocytopenia are frequently observed in hematological disorders, autoimmune hemolytic anemia is rarely reported. We experienced a case of primary Sjögren's syndrome developing severe autoimmune hemolytic anemia. The patient's red blood cells showed spontaneous agglutination in saline at room temperature, and immunoglobulin M (IgM) was detected on the surface of red blood cells by flow cytometry, indicating that autoimmune hemolytic anemia was caused by warm reactive IgM antibodies. Immediate corticosteroid therapy resulted in a dramatic recovery. We report a first case of severe autoimmune hemolytic anemia caused by warm reactive IgM antibodies in primary Sjögren's syndrome.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Severe autoimmune hemolytic anemia associated with IgM warm auto‐antibodies in primary Sjögren’s syndrome

et al. 2010

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“…We also draw the reader's attention to the aptly titled paper, '"Spectacular shrinking deficit": rapid recovery from a major hemispheric syndrome by migration of an embolus', which reports on 118 patients with an initial major hemispheric syndrome. 9 Of these, 12% had a spectacular shrinking deficit, attributed to further migration of embolus. The median onset of recovery was 2.5 h and the longest was 24 h. Now, instead of being recognised as a predictable part of the natural history of the disease, which we see in our clinical practice, such improvements bs_bs_banner Letters to the Editor…”

Section: General Correspondencementioning

confidence: 99%

“…Meiners et al reviewed 20 reported trials evaluating the effect of rituximab in SS patients and found that early, active disease with extraglandular manifestations are most likely to benefit from rituximab treatment. 7 AIHA is rare in SS but few case reports 8,9 have been reported. Corticosteroids are the mainstay of treatment for SS.…”

Section: Autoimmune Haemolytic Anaemia As An Initial Presentation Of mentioning

confidence: 99%

Autoimmune haemolytic anaemia as an initial presentation of primary Sjögren syndrome

Subbarayudu

Sharma²,

Sreemannarayana

2014

Internal Medicine Journal

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patients received secondary GCSF prophylaxis. Two patients withdrew from treatment. None of the patients required an intensive care unit admission.TC is a common adjuvant chemotherapy protocol used for management of early breast cancer. The reported incidence of neutropenic fever in the largest randomised trial for this regimen is 5% and 9.5% in the first cycle without primary GCSF prophylaxis. 2,6 One of the largest series of this protocol from Canada with 134 patients reported 38% incidence of neutropenic fever without primary prophylaxis similar to our study. 7 The recent metaanalysis of 902 patients treated with TC reported neutropenic fever rates of 29% without primary prophylaxis with relative risk reduction of 76% with GCSF prophylaxis. 4 In our study, the median age of patients treated with this protocol was similar to the US Oncology trial. The recent National Comprehensive Cancer Network guidelines also recommend the need for GCSF with this protocol. 8 We propose that Medicare reimbursement of GCSF for this protocol can decrease the morbidity for many patients and increase the costeffectiveness by reducing the number of neutropenic fever admissions. Figure 1 Light microscopy of the biopsy specimen obtained from a minor salivary gland biopsy (haematoxylin-eosin stain, ×40). Lymphocytes show periductal and perivascular infiltration (focus score >1).

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“…Various haematological abnormalities (such as anaemia, thrombocytopenia and leukopenia, in the presence or absence of auto-immune disease) are frequently reported in patients with SS [5][6][7]. The risk of developing non-Hodgkin's lymphoma in SS is well documented, and associations with other haematological malignancies, although uncommon, have been described [8,9].…”

Section: Introductionmentioning

confidence: 99%

Unusual association of two cases of acute myeloblastic leukaemia and possible Sjogren’s syndrome and review of literature

Brault¹,

Gourguechon²,

Chehimi³

et al. 2017

Hematol Leuk

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Autoimmune Hemolytic Anemia in an Elderly Patient with Primary Sjoegren's Syndrome

Cited by 10 publications

References 17 publications

Severe autoimmune hemolytic anemia associated with IgM warm auto‐antibodies in primary Sjögren’s syndrome

Severe autoimmune hemolytic anemia associated with IgM warm auto‐antibodies in primary Sjögren’s syndrome

Autoimmune haemolytic anaemia as an initial presentation of primary Sjögren syndrome

Unusual association of two cases of acute myeloblastic leukaemia and possible Sjogren’s syndrome and review of literature

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